Hongwei Wang, Applied Nutrition Manager, DuPont Nutrition & Health

•

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Nutrition & Biosciences

The impact of soy protein on gut microbiome and its benefits in across the lifespan.

Food

HongweiWangPhD,MD
Theimpactofsoyongut
microbiomeanditsbenefits
acrossthelifespan
May15,2017

DuPontConfidential
Copyright©2014DuPontN&HAllrightsreserved.
Thisstudyaimedtoinvestigatetheeffectofsoycomparedtodairyproteinonthegut
microbiotacompositioninahamstermodelofhumanlipidmetabolismandwhether
thesechangescouldaccountforapartofthelipidloweringpropertyofsoyprotein.
Hypothesis:Differentlyprocessedsoyproteinsvsmilkproteinconsumptioninthecontextof
aWesterndietwillbeassociatedwithadifferentmicrobiotaprofilethatisassociatedwithan
improvedlipidand/orglucosemetabolism
Design:GoldenSyrianHamstermodel
Moreappropriatemodelforhumanlipidmetabolism(comparedtoratormouse)
Interventionstudieslookingatgutmicrobiotachangesinresponsetodietsordrugshave
beensuccessfullyconductedinthisspecies*
SOYPROTEINCOMPAREDWITHMILKPROTEININAWESTERNDIET
INCREASESGUTMICROBIALDIVERSITYANDREDUCESSERUMLIPIDS
INGOLDENSYRIANHAMSTERSJournalofNutrition,2016
*1.WangC-Yetal.(2011),JSciFoodAgric91:2271-2276
2.MarinangeliCPFetal.(2011),ApplPhysiolNutrMetab36:811-820
3.PeterfreundGLetal.(2012),PLOSOne7:e46966
4.MartinezIetal.(2013),ApplEnvironMicrobiol79:516-524
Soyproteinhasdistinctimpactonmicrobiome

Copyright©2016DuPontN&H.Allrightsreserved.
ProteinQualityofcommonlyconsumedproteins
SUPROIsolatedSoyProtein
PDCAASistheglobally
recognizedmethodfor
determiningproteinquality
basedonaminoacidprofile
anddigestibility
(ISP)
SoyisaHighQualityProtein-PDCAAS(Protein
Digestibility-CorrectedAminoAcidScore)
PDCAAS=1.00
Comparabletomilk
&eggprotein
Canbeconsumed
throughoutthelife
cycle
Theonlycomplete
vegetableprotein
widelyavailable
Isolatedsoyprotein
islowinfat,
saturatedfat,
cholesterol-free
andlactose-free
soyproteinisahighqualityprotein

Copyright©2016DuPontN&H.Allrightsreserved.
SoyProteinhasdifferentiatedeffectsofhealth
Glucosemanagement
Kidneyhealth
Liverhealth
Guthealth
EmergingHealthAreasofDifferentiation
Highprevalence(11-46%)nonalcoholicfattyliverdisease(NAFLD)globally;higher
prevalenceinoverweight/obesity;soyproteintoreducefattyliverinanimalmodels
Invitedreviewofliteratureonsoy&
kidneyhealthpublishedQ22016
Literaturesupportroleforsoyprotein
AcutestudyongoinginIndia
EstablishedEvidence
Muscle
Health
Cardiometabolic
Heart
Health
Soyproteinresultsinmorediverseintestinalmicrobialcompositionand
consistentshiftsinspecificmicrobialfamilies,comparedtoanimalprotein.

Copyright©2016DuPontN&HAllrightsreserved.
HealthBenefitsofSoyProteinAcrosstheLifespan
Soyisahigh-quality,completeproteinwithhealthbenefitsacrossthelifespan
Acomboofsoyprotein,whey
&casein,helpsbuild&
maintainmusclemasswhile
providingalltheessential
aminoacids&nutrients
Milkformulatedwithsoy
proteingreatalternative
forchildrenwhoare
lactoseintolerantor
allergictodairy
Soyprotein,aspartof
anexerciseprogram,
canhelppreservelean
musclemass.
Soyprotein,aspartof
caloriecontrolleddiet,
canhelpweight
managementbyhelping
youfeelfuller,longer.
Soyformulasare
fortifiedwithvitamins&
mineralsdeliverthe
essentialnutritionfor
growth&development
25g/dofsoyprotein
candecreaseLDL-C
levels,whichmay
reduceriskforCVD
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