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MILD COGNITIVE IMPAIRMENT &
DEMENTIA MRI PROTOCOL
• High Resolution axial DP-T2 TSE
• 1.2 mm isotropic sagittal T1 3D MP-RAGE
(centered on thalamus)
• Coronal FLAIR
• Axial T2 Gradient Echo
• Diffusion Tensor Image (DTI)
Note:
1.- If necessary T1 3D MP-RAGE can be
used for Voxel Based Morphometry
2.- Axial T2 GE to discover small blood
foci secondary to amyloid angiopathy
• Entorhinal cortex
• Hippocampus
• Medial Orbital gyrus
• Cingulum
– Subgenual
– Retrosplenial
Mild Cognitive Impairment. Strategic Areas Study
Diffusion Tensor Image VOIs.-
Entorhinal
cortex
DTI VOIs.
Medial
Orbital
Gyrus
Retrosplenial
Cingulum
Subgenual
Cingulum
Hippocampus

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Mild cognitive Impairment & Dementia MRI Protocol

Editor's Notes

  1. Motivo de consulta: Deterioro cognitivo leve. Probable ictus parahipocampal izquierdo a CT. RM craneal: Se realiza RM mediante secuencias axial doble eco, coronal FLAIR, sagital MPRAGE 3D T1 y tensor de difusión con VOIs y ROIs en áreas estratégicas según protocolo. Fosa posterior de tamaño y morfología normal, con cuarto ventrículo de calibre normal y sin alteraciones en la unión mesencéfalo protuberancial. Mínimos higromas subdurales en cisternas supracerebelosas.Supratentorialmente el sistema ventricular es simétrico y no existen alteraciones en ganglios de la base. Lesiones de sustancia blanca en cápsulas externas y coronas radiatas bifrontales y algo mayores periatriales, en relación con isquemia de pequeño vaso.Se realizan VOIs y ROIs en áreas estratégicas, objetivándose preservación de la anisotropía de las fibras en todas las localizaciones salvo una ligera disminución en corteza entorrinal derecha. El agua libre, sin embargo, se encuentra aumentada en ambas cortezas entorrinales, cíngulos subgenuales y circunvoluciones orbitales mediales, siendo todo ello sugestivo de enfermedad degenerativa sistema nervioso central de tipo frontotemporal.CONCLUSIÓN: ISQUEMIA PEQUEÑO VASO SUPRATENTORIAL DISCRETA. HALLAZGOS QUE SUGIERAN ENFERMEDAD DEGENERATIVA SISTEMA NERVIOSO CENTRAL DE TIPO FRONTOTEMPORAL INCIPIENTE.