Medical astrology (traditionally known as iatromathematics) is an ancient medical system that associates various parts of the body, diseases, and drugs as under the influence of the sun, moon, and planets, along with the twelve astrological signs. Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being. People with depressed mood can feel sad, anxious, empty, hopeless, helpless, worthless, guilty, irritable, ashamed or restless. In ayurvedic line of treatmnet daivya vyapashraya chikitsa is mentioned in which mani, ratna dharan, mantro uchharan, graha shanti upaya has been said. Moon plays very important role in our life as it governs our emotions. 4th house represents mental peace, happiness and comforts. Worshipping Lord Shiva or offering water to Shiva Linga has always shown favorable results especially on Mondays. The most important remedy is to keep good interaction with your mother. If you don’t have a mother, then respect any elderly lady around you give her white flowers, milk, sugar, kheer, any white sweets and white cloth every Mondays.