1. FIRST MILK
CANCER
www.immunetree.com
877-295-1269
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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RECOMMENDED
NUCLEAR
FACTOR
REFERENCES
ChenHY,MollstedtO,TsaiMH,KreiderRB.PotentialClinicalApplicationsofMulti-FunctionalMilkProteins
and Peptides in Cancer Management. Curr Med Chem. 2014 Feb 5. [E-pub ahead of print]
An MJ, Cheon JH, Kim SW, Park JJ, Moon CM, Han SY, Kim ES, Kim TI, Kim WH. Bovine colostrum
inhibits nuclear factor kappaB-mediated proinflammatory cytokine expression in intestinal epithelial cells.
Nutr Res. 2009 Apr;29(4):275-280. doi: 10.1016/j.nutres.2009.03.011.
Masuda C, Wanibuchi H, Sekine K, et al. Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-
hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn J Cancer Res. 2000 Jun;91(6):582-
588.
Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the
treatment of gastrointestinal disorders. Am J Clin Nutr, 72, No(1), 5-14, July 2000
Hirano M, Iweakiri R, Fujimoto K, et al. Epidermal growth factor enhances repair of rat intestinal mucosa
damaged after oral administration of methotrexate. J Gastroenterol 1995;30:169–176.[Medline]
Sonis ST, Lindquist L, Van Vugt A, et al. Prevention of chemotherapy-induced ulcerative mucositis by
transforming growth factor beta 3. Cancer Res 1994;54:1135–1138.[Abstract]
Howarth GS, Francis GL, Cool JC, Ballard RW, Read LC. Milk growth factors enriched from
cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr
1996;126:2519–2530.[Medline]
Gordler NM, McGurk M, Aqual S, Prince M. The effect of EGF mouthwash on cytotoxic-induced oral
ulceration. Am J Clin Oncol 1995;18:403–406.[Medline]
FOOD FOR CHEMOTHERAPY
Colostrum should be considered as a front line food
for chemotherapy patients as it “enhances the repair of
rat intestinal mucosa damaged by methotrexate” and
“ameliorates chemotherapy-induced mucositis.”
SINGLE VS MULTIPLE PEPTIDES
Until recently, most research has focused on the
use of a single peptide for the treatment of a particular
condition. There is now increasing evidence, however,
that administration of a combination of many peptides can
result in additive or synergistic activity. “For example, the
coadministration of GH and IGF-I stimulates anabolism and
the coadministration of bovine lactoferrin and EGF stimulate
the growth of the rat intestinal epithelial cell line…Orally
administered colostrum-derived preparations therefore
appear to be an attractive therapeutic option because they
contain many different growth factors in a formulation that
provides inherent protection against proteolytic digestion.”
Immune-Tree first milking colostrum supplies peptides
in first milk that never has its fat removed since the fatty
acids protect the proteins as they go through the digestive
process. Immune-Tree first milking colostrum is obtained from
organically raised dairy cows fed pesticide-free grass.
C
utting down on cancer risk and treating it may
involve the potential clinical applications of first
milk proteins and peptides, say doctors writing in
Current Medicinal Chemistry.
Colostrum, also known as first milk, contains
therapeutic proteins and peptides that together
appear to reverse changes in the signaling of the tumor
micro environment that enhance cancer spread.
One in three Americans is likely to experience cancer.
Colostrum, a nutrient-rich fluid produced
by female mammals immediately after
giving birth, is loaded with immune, growth
and tissue repair factors with dozens of
biologically active peptides and proteins that
affect genes and cell signaling.
“The progression of cancer involves
multiple changes” in cellular signaling to
promote cell proliferation, the research
team said.
CANCER IMMUNOTHERAPIES
Several colostrum-derived biologics, such
as HAMLET (human α-lactalbuminmade lethal
to tumor cells) and the human recombinant
form of lactoferrin, already have “demonstrated
promising results in clinical trials.” Lactoferricin
peptide analogs are in early clinical development for cancer
immunotherapies.
“In addition, milk proteins and peptides are well
tolerated and many exhibit oral bioavailability, thus they may
complement standard therapies to boost overall success in
cancer treatments.”
CELL SIGNALING
One of the smoking guns of cancer causation is nuclear
factor kappaB (NF-kappaB) signaling, which
increases internal inflammation that changes
the ability of cancer cells to adhere to
tissues and spread. Human colon cancer
HT-29 cells were stimulated with interleukin
(IL)-1beta with or without bovine colostrum.
By inhibiting NF-kappaB signaling in HT-29
cells, bovine colostrum reduced adhesion
molecules and metastasis. “These data
demonstrated that bovine colostrum
might protect against [intestinal epithelial
cells] inflammation by inhibiting the NF-
kappaB pathway,” suggesting colostrum
has a therapeutic potential for intestinal
inflammation and cancer prevention.
Additional studies confirm cancer stopping
activity.
and
of
![FIRST MILK
CANCER
www.immunetree.com
877-295-1269
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
advertisement
RECOMMENDED
NUCLEAR
FACTOR
REFERENCES
ChenHY,MollstedtO,TsaiMH,KreiderRB.PotentialClinicalApplicationsofMulti-FunctionalMilkProteins
and Peptides in Cancer Management. Curr Med Chem. 2014 Feb 5. [E-pub ahead of print]
An MJ, Cheon JH, Kim SW, Park JJ, Moon CM, Han SY, Kim ES, Kim TI, Kim WH. Bovine colostrum
inhibits nuclear factor kappaB-mediated proinflammatory cytokine expression in intestinal epithelial cells.
Nutr Res. 2009 Apr;29(4):275-280. doi: 10.1016/j.nutres.2009.03.011.
Masuda C, Wanibuchi H, Sekine K, et al. Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-
hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn J Cancer Res. 2000 Jun;91(6):582-
588.
Playford RJ, Macdonald CE, Johnson WS. Colostrum and milk-derived peptide growth factors for the
treatment of gastrointestinal disorders. Am J Clin Nutr, 72, No(1), 5-14, July 2000
Hirano M, Iweakiri R, Fujimoto K, et al. Epidermal growth factor enhances repair of rat intestinal mucosa
damaged after oral administration of methotrexate. J Gastroenterol 1995;30:169–176.[Medline]
Sonis ST, Lindquist L, Van Vugt A, et al. Prevention of chemotherapy-induced ulcerative mucositis by
transforming growth factor beta 3. Cancer Res 1994;54:1135–1138.[Abstract]
Howarth GS, Francis GL, Cool JC, Ballard RW, Read LC. Milk growth factors enriched from
cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr
1996;126:2519–2530.[Medline]
Gordler NM, McGurk M, Aqual S, Prince M. The effect of EGF mouthwash on cytotoxic-induced oral
ulceration. Am J Clin Oncol 1995;18:403–406.[Medline]
FOOD FOR CHEMOTHERAPY
Colostrum should be considered as a front line food
for chemotherapy patients as it “enhances the repair of
rat intestinal mucosa damaged by methotrexate” and
“ameliorates chemotherapy-induced mucositis.”
SINGLE VS MULTIPLE PEPTIDES
Until recently, most research has focused on the
use of a single peptide for the treatment of a particular
condition. There is now increasing evidence, however,
that administration of a combination of many peptides can
result in additive or synergistic activity. “For example, the
coadministration of GH and IGF-I stimulates anabolism and
the coadministration of bovine lactoferrin and EGF stimulate
the growth of the rat intestinal epithelial cell line…Orally
administered colostrum-derived preparations therefore
appear to be an attractive therapeutic option because they
contain many different growth factors in a formulation that
provides inherent protection against proteolytic digestion.”
Immune-Tree first milking colostrum supplies peptides
in first milk that never has its fat removed since the fatty
acids protect the proteins as they go through the digestive
process. Immune-Tree first milking colostrum is obtained from
organically raised dairy cows fed pesticide-free grass.
C
utting down on cancer risk and treating it may
involve the potential clinical applications of first
milk proteins and peptides, say doctors writing in
Current Medicinal Chemistry.
Colostrum, also known as first milk, contains
therapeutic proteins and peptides that together
appear to reverse changes in the signaling of the tumor
micro environment that enhance cancer spread.
One in three Americans is likely to experience cancer.
Colostrum, a nutrient-rich fluid produced
by female mammals immediately after
giving birth, is loaded with immune, growth
and tissue repair factors with dozens of
biologically active peptides and proteins that
affect genes and cell signaling.
“The progression of cancer involves
multiple changes” in cellular signaling to
promote cell proliferation, the research
team said.
CANCER IMMUNOTHERAPIES
Several colostrum-derived biologics, such
as HAMLET (human α-lactalbuminmade lethal
to tumor cells) and the human recombinant
form of lactoferrin, already have “demonstrated
promising results in clinical trials.” Lactoferricin
peptide analogs are in early clinical development for cancer
immunotherapies.
“In addition, milk proteins and peptides are well
tolerated and many exhibit oral bioavailability, thus they may
complement standard therapies to boost overall success in
cancer treatments.”
CELL SIGNALING
One of the smoking guns of cancer causation is nuclear
factor kappaB (NF-kappaB) signaling, which
increases internal inflammation that changes
the ability of cancer cells to adhere to
tissues and spread. Human colon cancer
HT-29 cells were stimulated with interleukin
(IL)-1beta with or without bovine colostrum.
By inhibiting NF-kappaB signaling in HT-29
cells, bovine colostrum reduced adhesion
molecules and metastasis. “These data
demonstrated that bovine colostrum
might protect against [intestinal epithelial
cells] inflammation by inhibiting the NF-
kappaB pathway,” suggesting colostrum
has a therapeutic potential for intestinal
inflammation and cancer prevention.
Additional studies confirm cancer stopping
activity.
and
of](https://image.slidesharecdn.com/4d4adc6e-cc6c-4802-9ee6-4a2f3fabb89a-150226095228-conversion-gate01/85/Cancer-and-Colostrum-1-320.jpg)
