Abstract of the Presentation: Nocturne is the first product to offer OCT analyses specifically for neurological applications based on proprietary technology. The service works on data from standard optical coherence tomography (OCT), which is used in ophthalmology. In combination, diagnostic, treatment decisions, disease monitoring can be made directly in the neurologic practice. This speeds up treatment decisions in relevant neurologic disorders, in which early treatment response are greatly beneficial to the clinical outcome. About the Author: Dr. Ella Maria Kadas, CEO of Nocturne, is a mathematician specializing in mathematical image analysis. She completed her PhD at the NeuroCure Clinical Research Center (NCRC) of the Charité under the supervision of Prof. Dr. Friedemann Paul (NCRC) and Prof. Dr. Konrad Polthier Freie Universität Berlin from the research group "Mathematical Geometry Processing". Through her work in this interdisciplinary team of scientists and physicians she gained a lot of experience in the field of neurological imaging in the research group of Prof. Dr. Paul and on the latest geometric procedures and visualization methods in the research group of Prof. Dr. Polthier. Dr. Kadas has many years of experience in the analysis of OCT images in different clinical applications which have disease-specific and thus different morphological characteristics. Based on this expertise, Ms. Kadas has developed and implemented essential procedures of the Nocturne underlying technique.

1. THE EYE AS WINDOW TO THE BRAIN

2. Aging popula+on world wide
16%
14%
12%
10%
8%
6%
4%
1950 1960 1970 1980 1990 2000 2010 2020 2030 2040 2050
> 60 years

3. Medical diagnos+c tools
€ 1M-3M
€ 120-1800
40 min
milimeters
2%
50%
5min
1000x

4. The Solu+on

5. The Re+na
OCT Scan
Macula
Op+c nerve head

6. Applica+ons in neurological diseases
Healthy control! Multiple slerosis! Neuromyelitis Optica
Spectrum Disorder
Idopathic Intracranial
Hypertension

7. Applica+ons in neurological diseases
Microstructural visual system changes in AQP4-an+body–seroposi+ve NMOSD, Oertel et al.
Resample volume scan to the radial scan
using the bilinear interpolation
Resample volume scan
to the radial scan
Cubic Bezier Parametrization
Macula

8. Applica+ons in neurological diseases
Microstructural visual system changes in AQP4-an+body–seroposi+ve NMOSD, Oertel et al.

9. Applica+ons in neurological diseases
Op+c nerve head

10. Applica+ons in neurological diseases

11. Market entry as Web Service
Examina+on Data upload Analysis Re+na Report

12. > 2.3 million MulGple Sclerosis
> 4.5 million Parkinson‘s
> 46 million Alzheimer
Worldwide Europe
> 700.000 MulGple Sclerosis
> 1 200 000 Parkinson‘s
> 8 million Alzheimer

13. PharmaceuGcal Research
Academic research
Clinical
(CE mark mid 2019)
2 1

14. 2017 2018 2019 2020 2021
Alzheimer
Valida+on studies
3 Patents &Technology
Partnership with MIAC
Monitoring of Mul+ple Sclerosis
CE Mark
Parkinson's disease
Grant 50K
4 Research Projects 24K

15. CEO
Dr. Ella M. Kadas
PhD in Image processing
CTO
Dr. Sunil K. Yadav
PhD in MathemaGcal
modelling
CMO
Dr. Alexander U. Brandt
Medical & Science
ScienGfic advisor
Prof. Friedemann Paul
Clinical Affairs

16. Partners

17. Strategic partners
Academic Partners

18. Dr. Ella Maria Kadas
ella.kadas@nocturne.one
nocturne.one
„Window to the brain“