3. INTRODUCTION
Headache is pain in any region of the head.
Headache is pain originating from the surrounding structures of
the head i.e blood vessels, meninges, facial muscles, cranial or
spinal nerves e.t.c
There are different types of headache and each type of headache
has its own pathophysiology.
anatomical origin of headaches
headaches are actually refferred pain from any part of deep
tissues. the brain itself does not sense pain but can rather
interprete it. the head has got pain sensitive parts that sense pain
on the head. these areas are
• soft tissues: skin,mucus membrane,muscles and other soft
tissues on the face, ears,nose,scuple and throat are all pain
sensitive.
• the meninges of the brain.
• central and peripheral nervous system
• intercranial vessels
4. CLASSIFICATION
• PRIMARY HEADACHE
these are a class of headaches that affect or radiate any part of the head
and neck. patients usually experience these headaches on specific areas
of the head.
migrain
cluster
tension
• SECONDARY HEADACHE
on these types pain may not originally be stimulated on the head,it can be
refered from any part of the body.
sinus headache
spinal headache
rebound headache
hormonal headache
post- traumatic headache
5. CLASSIFICATION/ PATHOPHYSIOLOGY
OF HEADACHE
1. Tension Headache
Mild to moderate pain often described as feeling like a
tight band around the head.
Factors that can bring on a tension headache such as
stress, posture, alcohol use
Symptoms Of Tension Headache
Pain on both sides of the head
Difficulty falling asleep.
The pain is usually dull
Pain often described as feeling like a band around the
head
6. CLASSIFICATION/ PATHOPHYSIOLOGY
OF HEADACHE
2.Migraine Headache
Migraines are thought to involve a complex interplay of
neurovascular factors. One theory is the “neurovascular
theory” which suggests that there is initial vasoconstriction
followed by vasodilation leading to pain.
Another theory involves the trigeminovascular system.
Activation of the trigeminal nerve can lead to the release of
imflammatory molecules called neuropeptides such as
calcitonin gene- related peptide, which can cause pain and
blood vessel dilation.
7. CLASSIFICATION/ PATHOPHYSIOLOGY
OF HEADACHE
Conti...
Symptoms Of Migraine
Migraine headache is described as pounding, throbbing
sentation in one particular area that vary in intensity.
Sensitivity to light and sound
nausea and vomiting
pain especially on the forehead
The pain can be frequent/ severe
dizziness
8. CLASSIFICATION/ PATHOPHYSIOLOGY OF
HEADACHE
3. Sinus Headaches
Sinuses are structures inside your face that are normally
filled with air.
Bacterial infections, Viral infections, and allergies can
irritate them causing them to be or get blocked and filled
with fluid (Mucus).
Sinus headache can be caused by sinus congestion and
inflammation called sinusitis.
Symptoms Of A Sinus Headache
Face tender or swelling in your face
stuffy nose
worsening pain if the head is bent forward or lie down
pain is worse with sudden movements of the head.
9. CLASSIFICATION/ PATHOPHYSIOLOGY
OF HEADACHE
4. Spinal headache
Spinal headache happens when the amount of celebral spinal
fluid (CSF) around your brain decreases, it can be caused by
leakage of spinal fluid through a pancture hole in the membrane
that surrounds the spinal cord. This leakage decreases the
pressure exerted by the spinal fluid on the brain and spinal cord
which leads to headache.
Symptoms
The intense or throbbing headache that starts in front or back
of your head.
pain that worsens when sitted or standing and gets better
when you lie down
Neck pain or stiffness, Photophobia
10. CLASSIFICATION/ PATHOPHYSIOLOGY OF
HEADACHE
5. Cluster Headache
This headache is intense and severe unilateral headache which
is associated with autonomic features.
Pathophysiology involves activation of the trigeminal vascular
complex and the trigeminal-autonomic.
Symptoms
Eyelid dropping or swelling
One side of the head pain
Pain builds to a peak in about 10-15 minutes
Each episode of pain can last from 1- 3hrs
Daily episodes of pain over 2-3 months, after which there is a
remission for anything up to 2 years
Sweating on the forehead
11. CLASSIFICATION/ PATHOPHYSIOLOGY OF HEADACHE
6. Post- Traumatic Headache
This is the type of headache that occurs within seven days
following the trauma or within seven days after recovering
consciousness or the ability to sense.
The pathophysiology is still unknown, however, several
theories have been proposed to explain the underlying cause of
PTH. These include impaired descending modulation,
neurometabolic changes and activation of the trigeminal
sensory system.
Symptoms
Mood and personality changes like depression and
nervousness
Insomnia, Trouble in concertrating
The pain can be felt on the forehead, neck,back of the head.
12. CLASSIFICATION/ PATHOPHYSIOLOGY OF
HEADACHE
7. Rebound Headache (Medication overuse headache)
Pathophysiology: as a result of prolonged usage of pain
relievers which may trigger headaches.
Symptoms
Insomnia
difficulty in concertrating
Nausea and vomiting
Irritability
13. CLASSIFICATION/ PATHOPHYSIOLOGY OF
HEADACHE
8.Hormonal Headache
Pathophysiology: causes of hormonal headaches, especially
migraine headaches, have been linked to the female hormone
estrogen.
Estrogen controls chemicals in the brain that affect the
sensation of pain. A drop estrogen levels can trigger a
headache.
A menstrual migraine or hormonal headache start before or
during a womans period and can happen every month.
Symptoms
A dull, throbbing or severe pulsing headache
Sensitivity to light
Nausea, Fattigue, Dizziness
14. REFFERENCE
1. DALE, M. M., RANG, H.P., & DALE, M. M (2007). Rang & Dale’s pharmacology. [Edinburgh],
Churchill L ivingstone
2. Katzung BG. (Ed), Ed. Bertram G. Katzung. eds. Basics & Clinical Pharmacology, 14e.
McGraw-Hill