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C Y TherapyI
Personalized Cell TOR




       BioCentury Future Leaders Conference
                   April 5, 2013
                  NASDAQ: CYTX                1
Safe Harbor Statement
This presentation contains certain ‘forward-looking statements’ about Cytori Therapeutics, Inc. All
statements, other than statements of historical fact, that address activities, events or developments
that we intend, expect, project, believe or anticipate will or may occur in the future are forward-
looking statements. Such statements are based upon certain assumptions and assessments made by
our management in light of their experience and their perception of historical trends, current
conditions, expected future developments and other factors they believe to be appropriate.

The forward-looking statements included in this presentation involve known and unknown risks that
relate to Cytori’s future events or future financial performance and the actual results could differ
materially from those discussed in this presentation. Risks and uncertainties that may cause Cytori's
actual results to differ materially from those discussed in the presentation can be found in the "Risk
Factors" section of Cytori’s Form 10-K, Forms 10-Q and other filings with the United States Securities
and Exchange Commission. We would advise reading our most recent annual report on Form 10-K
and quarterly report on Form 10-Q filed with the United States Securities and Exchange Commission
for a more detailed description of these risks.

The forward-looking statements contained in this presentation represent Cytori’s estimates and
assumptions only as of the date of this presentation and Cytori undertakes no duty or obligation to
update or revise publicly any forward-looking statements contained in this presentation as a result of
new information, future events or changes in Cytori’s expectations.
                                                                                                     2
Cytori Cell Therapy


① Game changing technology platform

② Arriving at points of leverage
  • US Cardiac Data
  • Barda Contract
  • International Revenues

③ Expansive IP portfolio protects technology long-term




                                                         3
Cytori Cell Therapy

Proprietary formulation of a patient’s own adipose-
        derived stem and regenerative cells


                                         • Autologous

                                         • Virtual ‘off the shelf’

                                         • Mixed population

                                         • Multiple mechanisms

                                         • Patented process



                                                               4
Cytori Cell Therapy: Multiple Cell Types


               Vascular
                Smooth                          45
              Muscle Cells
Endothelial       9%            Tissue
 cells 7%
                             Macrophages        30
                                 23%


                                  White Blood
              CD34+/CD31                        15
                 - 37%               Cells
                                     22%

                                                0

                                                 Total Nucleated Cells in Adipose
                              Stem
                             Cells 2%




Heterogeneous Cell Therapy uniquely leverages multiple mechanisms
                                                               5
Cytori Cell Therapy: System + Single-Use Cartridge



                          Processing System:
                          Low six figure ASP




                          Per-procedure consumable:
                          $2,000-$12,000
                          Dependent on indications
                          and formulation
                          60-80% Margin

                                                      6
Cytori Cell Therapy: Business Overview



                                       Cardiac   • US heart failure trial




                     BARDA                            Commercial

 • Up to $106 in development funding                • Japan research market
 • US Government large end-customer                 • EU vascular approval
 • Cytori to sell into all other burn markets       • EU tissue ischemia approvals
                                                    • Cell & tissue banking
PRECISE Trial


          20.0
                 19.0

                                    P<0.05      P<0.02
          18.0
 VO2Max




                                      17.2       17.1
                                                  ADRC’s

                 16.6                                             Increased
          16.0                                                     Mortality

                                    15.5           Standard of Care
                                                 15.3
          14.0    Transplant List



                 Baseline           6 Mos       18 Mos

Change in Peak Oxygen Consumption (VO2Max) from Baseline to 6 & 18 months   8
                          N=27; 21 active, 6 control
PRECISE Trial: Max VO2 a Predictor of 1 Yr. Survival

Reflects the degree of impairment in:
• Ventricular function (pumping
   capacity)
• Vascular function (O2 delivery),
• Skeletal muscle metabolic capacity
   (O2 utilization).

Pts with Max VO2 ≤ 14 ml/kg/min had
a 1 year survival rate of only 47%.




Mancini et al, Circulation 1991
Figure: Survival curves for all patients
        subdivided by Max VO2 & EF
        (p<0.05; VO2 ≤ 10 vs. > 14 ml/kg/min)
U.S. Refractory Heart Failure Trial

Status:
    All centers actively screening
    •   Minneapolis Heart Institute (Timothy Henry MD)
    •   Texas Heart Institute (Emerson Perin MD, PhD, James, Willerson, MD)
    •   University of Florida (Carl Pepine MD)
    •   University of South Florida (Leslie W. Miller MD)
    •   Scripps Green Hospital (Richard Schatz MD)
    •   Cardiology P.C. (Farrell Mendlesohn MD)


    On-track to complete mid-Summer 2013

    6-month data first half 2014

    Pivotal Trial Design
    • Detailed protocol and trial size to be determined by ATHENA outcomes
    • Likely endpoints to include a functional and composite clinical outcome
                                                                                10
BARDA: Up to $106 MM for Thermal Burn Development

  U.S. Govt. contract: Thermal burns combined with radiation injury
   • National preparedness to counter radiological bomb
   • Funds complete development: preclinical to FDA submission
   • New soft tissue pipeline application in U.S.
   • Procurement potential above and beyond contract




                                    Options 1 & 2
• $4.7 MM in funding                                 • Up to $45 MM
• Preclinical model                                  • Pivotal trial
                          • Up to $55 MM
• Next-Gen Celution®                                 • FDA submission
                          • Development
  development
                            including clinical
• Up to 2 years
                          • Govt. has
              Proof-of-     procurement ability                  Option 3
              Concept
                                                                        11
BARDA: Supporting Desktop System Development

     Celution® System product and technological evolution
     1. Cytori developed interim Celution 800 System (Cytori)
     2. Olympus designed Celution One System (OC-JV)
     3. Cytori designed Next Gen System (BARDA)


1.                        2.                             3.




          Smaller. Faster. Cheaper. Higher Yields.
Translational Medicine: Near-Term Revenue Driver

Investigator-initiated trials resulting in:

• Meaningful sales to offset burn                                   Vascular CE
                                                                       Mark
                                                  Radiation
• Expansion of physician and                       injury
  hospital network

• Strategic benefit of development                            Incontinence
  of new applications/pipeline




                                              Pivotal trials, grants (BARDA),
                                                 partnerships, regulatory
                                               approvals, reimbursement
Financials

Current Select Data

PF cash & AR (YE 2012)   $32 MM

Senior Term Loan (GE)    $22 MM maturing in 2015

Shares outstanding       67 MM

Warrants                 10 MM @ $3.25 avg. exercise price

2013 Guidance

Revenue                  $15 MM ($12 m product, $3 m contract)

SG&A                     Flat for year

R&D                      Slight increase, more than offset by BARDA revenue
2013 Milestones


 Present / Publish PRECISE long-term data (18 months)
 Complete patient enrollment in ATHENA by mid-summer 2013
 Advance BARDA toward Phase II

 Achieve $15 million revenue target for 2013 (incl $2.5 - 3m Barda)

 Expand Celution approvals ( ie Canada, Australia)
Personalized CellQ&A
                 Therapy

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Biocentury Future Leaders of the Biotech Industry 2013

  • 1. C Y TherapyI Personalized Cell TOR BioCentury Future Leaders Conference April 5, 2013 NASDAQ: CYTX 1
  • 2. Safe Harbor Statement This presentation contains certain ‘forward-looking statements’ about Cytori Therapeutics, Inc. All statements, other than statements of historical fact, that address activities, events or developments that we intend, expect, project, believe or anticipate will or may occur in the future are forward- looking statements. Such statements are based upon certain assumptions and assessments made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this presentation involve known and unknown risks that relate to Cytori’s future events or future financial performance and the actual results could differ materially from those discussed in this presentation. Risks and uncertainties that may cause Cytori's actual results to differ materially from those discussed in the presentation can be found in the "Risk Factors" section of Cytori’s Form 10-K, Forms 10-Q and other filings with the United States Securities and Exchange Commission. We would advise reading our most recent annual report on Form 10-K and quarterly report on Form 10-Q filed with the United States Securities and Exchange Commission for a more detailed description of these risks. The forward-looking statements contained in this presentation represent Cytori’s estimates and assumptions only as of the date of this presentation and Cytori undertakes no duty or obligation to update or revise publicly any forward-looking statements contained in this presentation as a result of new information, future events or changes in Cytori’s expectations. 2
  • 3. Cytori Cell Therapy ① Game changing technology platform ② Arriving at points of leverage • US Cardiac Data • Barda Contract • International Revenues ③ Expansive IP portfolio protects technology long-term 3
  • 4. Cytori Cell Therapy Proprietary formulation of a patient’s own adipose- derived stem and regenerative cells • Autologous • Virtual ‘off the shelf’ • Mixed population • Multiple mechanisms • Patented process 4
  • 5. Cytori Cell Therapy: Multiple Cell Types Vascular Smooth 45 Muscle Cells Endothelial 9% Tissue cells 7% Macrophages 30 23% White Blood CD34+/CD31 15 - 37% Cells 22% 0 Total Nucleated Cells in Adipose Stem Cells 2% Heterogeneous Cell Therapy uniquely leverages multiple mechanisms 5
  • 6. Cytori Cell Therapy: System + Single-Use Cartridge Processing System: Low six figure ASP Per-procedure consumable: $2,000-$12,000 Dependent on indications and formulation 60-80% Margin 6
  • 7. Cytori Cell Therapy: Business Overview Cardiac • US heart failure trial BARDA Commercial • Up to $106 in development funding • Japan research market • US Government large end-customer • EU vascular approval • Cytori to sell into all other burn markets • EU tissue ischemia approvals • Cell & tissue banking
  • 8. PRECISE Trial 20.0 19.0 P<0.05 P<0.02 18.0 VO2Max 17.2 17.1 ADRC’s 16.6 Increased 16.0 Mortality 15.5 Standard of Care 15.3 14.0 Transplant List Baseline 6 Mos 18 Mos Change in Peak Oxygen Consumption (VO2Max) from Baseline to 6 & 18 months 8 N=27; 21 active, 6 control
  • 9. PRECISE Trial: Max VO2 a Predictor of 1 Yr. Survival Reflects the degree of impairment in: • Ventricular function (pumping capacity) • Vascular function (O2 delivery), • Skeletal muscle metabolic capacity (O2 utilization). Pts with Max VO2 ≤ 14 ml/kg/min had a 1 year survival rate of only 47%. Mancini et al, Circulation 1991 Figure: Survival curves for all patients subdivided by Max VO2 & EF (p<0.05; VO2 ≤ 10 vs. > 14 ml/kg/min)
  • 10. U.S. Refractory Heart Failure Trial Status: All centers actively screening • Minneapolis Heart Institute (Timothy Henry MD) • Texas Heart Institute (Emerson Perin MD, PhD, James, Willerson, MD) • University of Florida (Carl Pepine MD) • University of South Florida (Leslie W. Miller MD) • Scripps Green Hospital (Richard Schatz MD) • Cardiology P.C. (Farrell Mendlesohn MD) On-track to complete mid-Summer 2013 6-month data first half 2014 Pivotal Trial Design • Detailed protocol and trial size to be determined by ATHENA outcomes • Likely endpoints to include a functional and composite clinical outcome 10
  • 11. BARDA: Up to $106 MM for Thermal Burn Development U.S. Govt. contract: Thermal burns combined with radiation injury • National preparedness to counter radiological bomb • Funds complete development: preclinical to FDA submission • New soft tissue pipeline application in U.S. • Procurement potential above and beyond contract Options 1 & 2 • $4.7 MM in funding • Up to $45 MM • Preclinical model • Pivotal trial • Up to $55 MM • Next-Gen Celution® • FDA submission • Development development including clinical • Up to 2 years • Govt. has Proof-of- procurement ability Option 3 Concept 11
  • 12. BARDA: Supporting Desktop System Development Celution® System product and technological evolution 1. Cytori developed interim Celution 800 System (Cytori) 2. Olympus designed Celution One System (OC-JV) 3. Cytori designed Next Gen System (BARDA) 1. 2. 3. Smaller. Faster. Cheaper. Higher Yields.
  • 13. Translational Medicine: Near-Term Revenue Driver Investigator-initiated trials resulting in: • Meaningful sales to offset burn Vascular CE Mark Radiation • Expansion of physician and injury hospital network • Strategic benefit of development Incontinence of new applications/pipeline Pivotal trials, grants (BARDA), partnerships, regulatory approvals, reimbursement
  • 14. Financials Current Select Data PF cash & AR (YE 2012) $32 MM Senior Term Loan (GE) $22 MM maturing in 2015 Shares outstanding 67 MM Warrants 10 MM @ $3.25 avg. exercise price 2013 Guidance Revenue $15 MM ($12 m product, $3 m contract) SG&A Flat for year R&D Slight increase, more than offset by BARDA revenue
  • 15. 2013 Milestones Present / Publish PRECISE long-term data (18 months) Complete patient enrollment in ATHENA by mid-summer 2013 Advance BARDA toward Phase II Achieve $15 million revenue target for 2013 (incl $2.5 - 3m Barda) Expand Celution approvals ( ie Canada, Australia)