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1. MHC-Peptide Tetramer
Categories List:
 MHC-peptides Tetramer Class Ⅰ
 MHC-peptides Tetramer Class Ⅱ
Creative Peptides has launched a series of MHC-peptide Tetramers which
are ready-to-use reagents conjugated to a fluorochrome group such as Brilliant
Violet 421(BV421), phycoerythrin (PE), or allophycocyanin (APC).
In 1996, the development of reagents consisting of soluble MHC class I–
peptide complexes, which was applied to detect CD8+ cells by flow cytometry,
had effectively promoted a revolution of antigen-specific T cells. Traditionally,
TCR (T cell receptor) has a low avidity and fast off-rate for MHC-peptides
complexes, recombinant soluble monomeric MHC-peptide complexes have
not been used to detect antigen-specific T cells. Recently, Stanford University
School of Medicine has presented MHC-peptides tetrameric complexes (MHC
tetramers) in the detection of antigen-specific T cells, thus provided an efficient
method to visualize, quantify, phenotype and sort antigen-specific cytotoxic T
lymphocytes (CTLs) directly from a wide range of biological samples and have
now become standard reagents in laboratories around the world.

2. MHC tetramer is a complex of four MHC molecules, which are associated with
a specific peptides and bounded to a fluorochrome. The development of the
fluorescently labeled tetrameric MHC–peptide complex has enabled the direct
visualization, quantification and phenotypic characterization of antigen-specific
T cells by using flow cytometry, and has transformed scientists understanding
of cellular immune responses.
Creative Peptides develops, manufactures and markets a wide range of
MHC-peptide Tetramers. Our MHC-Peptide Tetramer services provide
customized MHC/peptide tetramers for identification of antigen specific T
lymphocytes by flow cytometry. With years of experience in one-stop services
including manufactures of MHC-peptide Tetramer, custom synthesis of related
peptides, and even MHC-Tetramer assay services, Creative Peptides must
be your exclusive choice in solving scientific and clinical challenges by
providing a consultative approach, superior technical and customer support. If
you are interested in any MHC Tetramer products, please feel free to contact
us at contact@creative-peptides.com. We will be more than happy to serve
you!