1-Open the following Cytoscape session files- 2- Create network views.docx

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This document provides instructions to analyze protein interaction networks using Cytoscape and its apps: open session files, create views and save images of networks, compute centrality metrics like betweenness and degree on the networks to identify top 5 residues, map residues on protein structures in Pymol, and write a paragraph with biological interpretation of the results.

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1.Open the following Cytoscape session files. 2. Create network views and save pictures of the
networks. 3. Compute network parameters (Betweenness, Short Path Length, Degree) fc the
networks, save in the table and identify the top 5 high centrality residues Use RINanalyzer and/or
RINspector apps. You may want to try several centre metrics and compare the results. 4. Map
residues on protein structure using Pymol. 5. Write a paragraph with some biological rationale
behind your results.

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