The document discusses the hematopoietic cell transplant (HCT) program at City of Hope Medical Foundation. It notes that the program is the second largest in the US, performing over 13,000 transplants. The focus and volume of the program has led to rapid integration of new therapies, continuous quality improvement, and survival outcomes above expected levels for 11 consecutive years according to an analysis by the Center for International Blood and Marrow Transplant Research. The analysis shows City of Hope is the only transplant center in the US to have performed above expected survival levels for 11 straight years.

1. Focus Factories: The Advantages of the
Specialized Approach - City of Hope
Harlan Levine
Chief Execu2ve, City of Hope Medical Founda2on

2. Focus Factory Case Study:
COH Hematopoie?c Cell Transplant (HCT) Program
• Flagship program founded 41 years ago
• Performed more than 13,000 marrow and
blood stem cell transplants
– Second largest HCT program in United States (650/
year)
• Volume and focus lead to:
– Rapid integraLon of phase I clinical trial and novel
therapeuLcs into transplant regimens
– Data-driven, mulL-stakeholder quality program
drives conLnuous process improvement
– Only HCT program in the United States to achieve
survival outcomes above risk-adjusted expected
survival for 11 consecu?ve years

3. CIBMTR Analysis of 1-year Survival for Allogeneic Transplanta<on
1: -1 indicates under-performing; 1 indicates over-performing; 0 indicates performing as predicted.
2: 2012 includes unrelated and related HCTs performed in 2008-2010; 2013 includes unrelated and related HCTs performed 2009-2011;
2014 includes unrelated and related HCTs performed 2010-2012.
In the U.S., only
City of Hope has
performed above
expecta?on for
11 consecu?ve
repor?ng years
• Center for InternaLonal Blood & Marrow Research released data showing hematopoieLc
stem cell transplant survival outcomes (most recent results published 12/15)
• Our rates for one-year survival were among the best
– Predicted one-year survival: 67.7% (95%CI: 64.6-71.0)/Actual one-year survival: 75.2
Performance by Report Year1,2
Center Center Name 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
60 Shands HealthCare & University of Florida 1 0 0 0 0 0 -1 0 0 1 1
61 University of Iowa Hospital & Clinics 0 -1 0 0 0 0 -1 0 0 1 1
63 Johns Hopkins Oncology Center 0 0 0 0 0 1 1 1 0 0
65 Cleveland Clinic 0 0 0 0 0 0 0 0 0 -1 0
68 University of PiVsburgh Medical Center 0 0 0 0 0 -1 0 0 0 0 0
69 University of Wisconsin Hospital & Clinics -1 0 0 1 1 0 0 0 0 0 0
70 Froedert & Medical College of Wisconsin 0 -1 -1 -1 -1 0 0 0 0 1 1
73 Wayne State University Hospital (Karmanos) 0 -1 -1 0 0 0 1 1 1 0 0
74 All Children's Hospital 0 0 0 -1 -1 -1 0 0 0 0 0
76 Children's Hospital of Los Angeles 0 0 0 0 0 0 0 -1 -1 0 0
78 Dana Farber Cancer Ins<tute-Adults 1 0 1 1 1 1 0 0 0 1 1
79 University of California-San Francisco-Pediatrics 0 0 0 0 0 0 1 1 0 0 0
80 Vanderbilt University 0 0 0 0 0 0 0 1 1 1
81 City of Hope Na<onal Medical Center 1 1 1 1 1 1 1 1 1 1 1