2. RESPONSE OF THE TUMOR
TO CHEMOTHERAPY
Complete response –
Resolution of all clinical disease, confirmed by
two observations not less than 4 wks apart.
Partial response –
Reduction of at least 30% of measurable
lesion, lasting at least one month, no new
lesions and no progression of any new lesion.
3. RESPONSE OF THE TUMOR
TO CHEMOTHERAPY
Stable disease –
No change in the tumor size or a reduction by less than
30% or an increase by less than 20% of the original
disease.
Progressive disease –
A 20% or more increase in the largest diameter of at
least one measurable or evaluable lesion or the
appearance of new lesions.
Time to treatment failure –
Time between inclusion till treatment failure
4. RESPONSE OF THE TUMOR
TO CHEMOTHERAPY
Duration of response : Measured from the
time, when the measurement criteria are met
for complete response or partial response until
the first date of recurrent or progressive
disease is documented.
ORR = CR+PR
5. Adjuvant therapy :
Use of chemotherapy (secondarily) after the prior
surgical treatment, to improve the overall outcome of
the therapy
Neoadjuvant therapy :
Use of chemotherapy prior to local treatment to
reduce the tumor bulk. This makes application of the
local therapies easier and may reduce their severity
Palliative treatment – given in metastatic settings
6. DISEASE FREE SURVIVAL
(DFS)
• analyze results of treatment for localized disease which
renders the patient apparently disease free, such as
surgery or surgery plus adjuvant therapy.
• the event is relapse rather than death.
• People who relapse are still surviving but they are no
longer disease-free.
• Disease Free Survival is also called Relapse Free Survival
DFS: Time from randomization until recurrence of tumor
or death from any cause
7. PROGRESSION FREE
SURVIVAL (PFS)
• analyzing results of treatment for advanced disease.
• The event for PFS is that the disease gets worse or "progresses"
meaning the existing tumors grew or new tumors appeared.
• Logically, Disease Free Survival could be considered a subset of PFS
since relapse represents progression of disease
• Like DFS, PFS attempts to isolate the effects of the current treatment
without being affected by what might be done after that treatment fails
• Death is consider as a Progression
PFS: Time from randomization until objective tumor
progression or death.
12. FUTURE OF CANCER
TREATMENT
• Chemoprevention – the ability to use drugs or lifestyle modifications to
prevent cancer from developing
• Improvement in staging – detecting many fewer cells or identifying
blood tests that tell about the presence of cancer
• Determining a specific “finger print” of an individual's cancer
• Selecting a specific treatment, based upon the likelihood of the cancer
to respond to that treatment AND minimizing the side effects of
treatment
