Sharing thoughts during the session Personalized Medicine at the Health Valley Event 2016, which again was a great event with 1100+ health care innovators !

1. Personalised
Medicine

2. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool

3. Personalized Medicine:
moving towards Personalized
Health(care)
Professor of Personalized Healthcare
Head Radboud Center for Proteomics, Glycomics
and Metabolomics
Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Prof Alain van Gool
Health Valley Event 2016
17 March 2016
Scientific lead DTL-Technologies Head Biomarker Platform

4. Source: Chakma, Journal of Young Investigators, 16, 2009
Principle of Personalized Medicine
4
• The right drug for right patient at right dose at right time
• Molecular biomarkers as key drivers of patient selection
• = Precision medicine or Targeted medicine
4 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

5. Companion diagnostics
Good examples personalized medicine in Oncology and Neurosciences:
• Cyp450, Her2/neu, BRCA, BRAF, EGFR, EML4/ALK, etc
Emerging companion diagnostics, also linked to non-drug therapies:
• Volker: Intestinal surgery → XIAP → Cord blood
• Beery twins: Cerebral palsy → SPR → Diet 5HTP
• Wartman: Leukemia → FLT3 → Sunitinib
• Gilbert: Healthy → BRCA → Mas/Ovarectomy
• Snyder: T2Diabetes → GCKR, KCNJ11 → Diet, exercise
• Lauerman: Scotoma, leg → JAK2 → Aspirin
• Bradfield: Healthy → CDH1 → Gastrectomy
Coming up: metabolic biomarkers, imaging biomarkers
5 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

6. Moving towards Personalized Health(care)
“The term "personalized medicine" is
often described as providing "the
right patient with the right drug at
the right dose at the right time."
More broadly, "personalized
medicine" may be thought of as the
tailoring of medical treatment to the
individual characteristics, needs, and
preferences of a patient during all
stages of care, including prevention,
diagnosis, treatment, and follow-up.”
(FDA, October 2013)
6
6 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

7. Personal need in efficient personalized health(care)
It’s personal !
‘I want to stay healthy.’
‘If not, how do I get healthy?’
7 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

8. 3 key aspects of personalized health(care)
‘I want to stay healthy. If not, how do I get healthy?’
1. What to measure?
2. How much can it change?
3. What should be the follow-up for me?
8 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

9. Exponential technological developments
• Next generation sequencing
• DNA, RNA
• Risk analysis and therapy selection
• Mass spectrometry
• Proteins, metabolites
• Monitoring of disease and treatment effects
• Imaging
• Non invasive images, real time
• Spatial view of intact organs and organisms
500
1000
1500
2000
m/z
5 10 15 20 25 30 35 40 Time [min]
9 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

10. … but not all data is useful data !

11. Translation is key in personalized health(care)
Personal profile data
Knowledge
Understanding
Decision
Action
Shared decision making
11 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

12. Translation is key in Personalized Healthcare !
“I’m afraid you’re
suffering from an
increased IL-1β and
an aberrant miR843
expression”
Adapted from:
?
12 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

13. Personalized health(care) model
Personalized
Intervention
of patients-like-me
Personal thresholds
of persons-like-me
Big
Biomarker
Data
Molecular
Non-molecular
Environment
…
Time
Disease
Health
Selfmonitoring
Adapted from Jan van der Greef, TNO
Personal profile
Personalized health
Personalized medicine
13 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

14. Personalized health(care) monitoring as part of our lives
• Monitor on background
• Alert when you are at risk
• Advice what to do
Examples from car dashboard:
• Empty gas tank
• Traffic jam ahead
14 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

15. 15 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
15
New data
(generators, owners)

17. Not all innovations are useful
17 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
Patient AdherenceCurrent
Disease
progression
Disease
stable
€
Effect
NEW innovative platform
(app to improve adherence to therapy)
Added
value ? Health Technology Assessment
Hemofilia NO
CML YES
Richard van der Broek
Sabine Mulders

18. 18 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
What’s next?
Simulating YOUR health
Heleen Wortelboer
Herman van Wietmarschen
Jan van der Greef
Esther Zondervan
Wim van Hartingsveldt

19. 19 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016
What’s next?
Simulating YOUR health + Personalized advice + Feedback

20. Acknowledgements
Ron Wevers
Jolein Gloerich
Hans Wessels
Dirk Lefeber
Monique Scherpenzeel
Leo Kluijtmans
Lucien Engelen
Nathalie Bovy
Paul Smits
Maroeska Rovers
Bas Bloem
the Technology Centers
and many others
www.radboudumc.nl/personalizedhealthcare
www.radboudresearchfacilities.nl
www.radboudumc.nl/research/technologycenters
alain.vangool@tno.nl
alain.vangool@radboudumc.nl
www.linkedIn.com
www.slideshare.net/alainvangool
Many collaborators and funders
Jan van der Greef
Ben van Ommen
Bas Kremer
Cyrille Krul
Ivana Bobeldijk
Lars Verschuren
Marjan van Erk
Peter van Dijken
Peter Wielinga
Ronald Mooij
Suzan Wopereis
and many others
CarTarDis
20 Alain van Gool, Maasziekenhuis Pantein, Boxmeer, 17 Mar 2016

21. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool

22. Personalized Medicine:
Conclusions and follow-up
Professor of Personalized Healthcare
Head Radboud Center for Proteomics, Glycomics
and Metabolomics
Coordinator Radboud Technology Centers
Senior Scientist Integrator Biomarkers
Prof Alain van Gool
Health Valley Event 2016
17 March 2016
Scientific lead DTL-Technologies Head Biomarker Platform

23. Nationale ongoing & planned events

24. Nationale wetenschaps agenda
24

25. Nationale wetenschaps agenda
25

26. 16
routes
26
Workshops
April/May
Advice to
government

27. Health RI
27
Downloadable at www.dtls.nl

28. Health RI
28

29. Health RI
29

30. 26th May – ‘Our Future health’ virtual conference
30
http://ourfuturehealth.org/news/can-we-change-the-way-we-conference/

31. Special Interest
Groups

32. Oprichting Special Interest Groups (S.I.G.)
- Krachtenbundeling in de regio
- Per thema één S.I.G.
- Kartrekkers gezocht (per S.I.G. 3 á 4 personen)
- Deelnemers actief via netwerkapp community
- S.I.G. brainstormt over content, sprekers, thema’s
- Health Valley zorgt voor sessies en events
- Meld je bij de sessievoorzitter, Marc Kalf of Victor Haze
(Meeting Point Health Valley of via de Netwerk app)

33. 9:00-9:15 Alain van Gool, Radboudumc, TNO
9:15-9:35 Diederik Bruins, Fortified Food Coatings
9:35-9:55 Leon Terstappen, Utwente
9:55-10:15 Andrea van Elsas, Aduro Botech
10:15-10:25 Closure Alain van Gool