Only educational purpose for students. Non small cell lung cancer , its type of cancer and mostly common type of cancer .

1. Non Small Cell
Lung Cancer
By - Abhijit Gaikwad
Subject :
Pharmacotherapeutic
Roll No :220 (SYPD)
Assignment No 2

2.  Non Small Cell Lung Cancer
 Non Small Cell Lung Cancer (NSCLC) is the
most common type of lung cancer .
 Lung cancer develops when lung cells starts
grow uncontrollably .
 The term "non-small cell lung cancer" applies
to the various types of bronchogenic
carcinomas (those arising from the lining of the
bronchi)

3.  There are three kinds of NSCLC tumors -
02
Section 02

4.  Signs
• Chronic
coughing
• Chest and bone
pain
• Difficulty
Swallowing
• Wheezing
sound
 Causes
• Radon
• Asbestos
• Metal Dust
• Air pollution
• AIDS/HIV
 Symptoms
• Chest Pain
• Pneumonia
• Bronchitis
• Feeling Tired
• Rust colored
mucus

5. ● Non-small cell lung cancer
● For this type of cancer, doctors usually
use a four-stage system.
● Stage 1: This signifies that the cancer is
only in the lungs.
● Stage 2: The cancer has reached nearby
lymph nodes.
● Stage 3: The cancer has spread to other
lymph nodes in the chest, possibly to
those in the middle or the other side of
the chest.
● Stage 4: The cancer has spread to both
lungs, to other parts of the body, or both.
●

6.  Pathophysiology
Carcinogens like smoking and environmental agents.
Binds with cells DNA and damage the cells .
Cellular changes and abnormal cell growth occur .
Abnormal proliferation of the lung cell .
These cells grow slowly and covers the segmental bronchi
and lobes of the lung .

7. Cont…
Non specific inflammatory changes with hypersecretion of mucus .
Lesions formation in the lungs tissues involving the bronchi ,
bronchioles or even alveoli
Bronchogenic carcinoma .

8.  Treatment -
• Surgery: A surgeon will remove cancerous cells and
any nearby lymph nodes that may be affected.
However, if cancer affects a large portion of the lungs,
surgery may not be possible.
• Chemotherapy: A doctor will administer powerful
drugs that can kill cancer cells.
• Endoscopic stents: If a tumor has blocked part of the
airway, a surgeon may insert a stent.
• Radiation therapy: A radiologist will direct a beam of
radiation toward malignant cells to destroy them.
• Targeted treatments: These drugs target specific
genes or other factors that enhance cancer’s ability to
grow. Blocking these factors can help stop or delay the
growth of some types of cancer.

9.  Treatment (Pharmacological) –
1. Previous drugs
 Tarceva :
Recommended daily dose of tarceva for NSCLC taken on an empty
stomach .
Dose 25- 150mg PO OD
 Opdivo :
Its cancer medicine used alone or combination with other medicines
.
Dose 50 – 100 mg IV Biweekly
 Xalkori :
Its cancer medication that interferes with growth and spread of
cancer cells in the body .
Dose 200 – 250 mg PO OD/BID
 Tagrisso :
Dose 40 – 80 mg PO OD

10. 2. New drugs approved by FDA
 Tabrecta (Capmatinib)
Date of approval – 6 may 2020
Dose – 200 to 300 mg PO BID
 Retevmo (Selpercatinib)
Date of approval - 8 may 2020
Its kinase inhibitor for the treatment of patients .
Dose – 40 mg to 80 mg PO OD
 Pemfexy (Pemetrexed)
Date of approval – Feb 2020
Dose – 500 mg IV for 21 day
Initial treatment of patients.

11.  Cont…
 Zepzelca (lurbinectedin)
Selective oncogenic transcription inhibitor indicated for treatment of adult
patients .
Date of approval - June 2020
Dose – 3 to 4 mg/ m2 IV q 21 day
 Gavreto (Pralsetinib ) capsules
Date of approval – September 2020
Gavreto is an oral selective RET kinase inhibitor .
Dose – 100 to 400 mg PO OD

12. Thank You