cancer chemotherapy drug classification, cytotoxic drugs,hormonal therapy,targeted therapy,broad classification

1. Chemotherapy Drugs
Dr. Aastha Shah
Oncologist

2. CYTOTOXIC DRUGS
Alkylators Platins Antimetabolites Microtubule Topoisomerase Antibiotics Misc
damagers inhibitors

3. ALKYLATORS
1.Methylhydrazine Procarbazine
2.Ethylenimine Thiotepa,Altretamine
3.Nitrosoureas Carmustine(BCNU),Lomustine(CCNU)
4.Triazines Dacarbazine,Temozolomide
5.Alkyl sulfonates Busulfan
6.Nitrogen mustards Mechlorethamine,Cyclophosphamide,
Ifosfamide,Chlorambucil,Bendamustine,
Melphalan

4. PLATINS
1.Cisplatin First generation platin
2.Carboplatin Second generation platin
3.Oxaliplatin Third generation platin
4.Satraplatin Orally available platin

5. ANTIMETABOLITES
1.Folate antagonists Methotrexate,Pemetrexed,Pralatrexate
2.Purine antagonists 6-Mercaptopurine,6-Thioguanine,Azathioprine,Fludarabine
3.Pyrimidine antagonists 5-Fluorouracil,Capecitabine,Doxyfluridine,Cytarabine,
Gemcitabine

6. MICROTUBULE DAMAGERS
1.Vinca alkaloids Vincristine,Vinblastine.Vinorelbine
2.Taxanes Paclitaxel,Docetaxel
3.Estramustine

7. TOPOISOMERASE INHIBITORS
1.Topoisomerase I inhibitors Topotecan,Irinotecan
2.Topoisomerase II inhibitors Etoposide,Tenoposide

8. ANTIBIOTICS
1.Anthracyclines Doxorubicin,Daunorubicin,Idarubicin,Mitoxantrone
2.Actinomycin D
3.Mitomycin C

9. MISCELLANEOUS
1.Hydroxyurea
2.L-Asparaginase
3.Tretinoin
4.Arsenic Trioxide

10. HORMONAL DRUGS
1.Glucocorticoids Prednisolone,Dexamethasone
2.Estrogens Ethinyl estradiol,Fosferol
3.SERMs Tamoxifen,Toremifene
4.SERD Fulvestrant
5.Aromatase inhibitors Letrozole,Anastrozole,Exemestane
6.5-alpha reductase inhibitors Finasteride,Dutasteride
7.Progestins Hydroxyprogesterone acetate
8.GnRH analogues Nafarelin,Leuprorelin,Triptorelin

11. TARGETED DRUGS
BCR-ABL TK inhibitors Imatinib,Dasatinib,Nilotinib,Bosutinib,
Ponatinib
EGFR inhibitors(HER 1 inhibitors)
HER 2 inhibitors
Gefitinib,Erlotinib,Cetuximab
Trastuzumab,Lapatinib
Angiogenesis inhibitors Bevacizumab,Sunitinib,Sorafenib
Proteasome inhibitors Bortezomib
CD20 inhibitors Rituximab etc….etc….list goes on