H2O.ai brings AI to enterprises with its scalable, distributed open-source machine learning platform H2O. We give an overview and show live demos of large-scale model training and deployment, including GPU-enabled deep learning and gradient boosting models. We present digital transformation use cases in financial services, healthcare, insurance and other verticals. We also share our insights into what the future of machine learning and deep learning might look like, and how to best prepare for it.