Air Influx Hanged Man ARISTOLE Leonardo Da vinci
The penis does not obey the order of its master who tries to erect or shrink it at will. Instead the penis erects freely while its master is asleep , the penis must be said to have its own mind by any stretch of the imagination. The penis does not obey the order of its master who tries to erect or shrink it at will. Instead the penis erects freely while its master is asleep , the penis must be said to have its own mind by any stretch of the imagination.
A single subtherapeutic intracavernous injection of the human recombinant Maxi-K ion channel gene via a "naked DNA" plasmid vector (hMaxi-K) is safe in men with moderate to severe erectile dysfunction (ED).
The hMaxi-K injection increases the expression of the Maxi-K channel in a small percentage of penile smooth muscle cells, whose signal for smooth muscle relaxation upon neural stimulation is amplified by gap junctions.
The primary function of K channels is to modulate Ca++ influx through Ca-channels. The amount of Ca++ that enters the cell through these channels is a major determinant of the free intracellular calcium levels inside the smooth muscle cell, which in turn determines the degree of smooth muscle cell contraction.
Increased Maxi-K channel activity is associated with smooth muscle cell relaxation, resulting in penile erection and detrussor muscle relaxation.
hMaxi-K hMaxi-K isn't just for getting erections; it may also be effective in other ailments including overactive bladder, asthma, irritable bowel syndrome, benign prostatic hyperplasia, premature labor, and premenstrual syndrome. New Horizons in ED Treatment
3 -I.C.I 4 -Penile prosthesis (risk of infection) 5 - Surgery (poor response) TREATMENT
Penile Prosthesis Indications: - Patients who have failed other therapies - Peyronie’s disease - Severe vasculogenic disease
Malleable Prosthesis - Easy for patient and partner to use - Few mechanical parts - Same-day surgery usually possible - Least expensive type of prosthesis
Two-Piece Inflatable Prosthesis - Small inflation pump provides comfort and ease - Fast and easy one-step deflation procedure - Better conceal ability when flaccid than with malleable or self-contained devices
Three-Piece Inflatable Prosthesis - Most closely approximates the feel of a natural erection - Cylinders expand in girth - Some cylinders have the potential to expand in length - When inflated, it feels more firm and more full than other prosthetic erections - When deflated, it feels softer and more flaccid with better conceal ability than with other prosthetic devices
Careful evaluation is needed to point out the underlying cause of the main problem. The treatment must be based on aetiologic factor(s) PDE5 inhibitors are safe medications for ED; however, new drugs have shown promising results in the ongoing clinical trials. Conclusions