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[object Object],[object Object],[object Object],[object Object],[object Object],Didier Raoult - [email_address] - Marseille - France U R
Objective ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unknown genosphere by metagenomics studies ,[object Object],[object Object],[object Object],DNA sequences of the living in the XXI th century Edwards RA, Rohwer F. Viral metagenomics. Nature Rev Microbiol. 2005;3:504-510. U R
U R ,[object Object],[object Object],[object Object],[object Object],[object Object],P.Colson. Pepper Mild Mottle Virus, a Plant Virus Associated with Specific Immune Responses, Fever, Abdominal Pains, and Pruritus in Humans .Plos one.2010
Tools  Culture- introducing culturomics
 
 
Free-living bacterial community Merhej V, et al. Biol Direct . 2009 Apr 10;4:13. 264 lost COGs Facultative host-associated Bacteria GS 2.92 ± 1.6 GC 43.0 ± 11.7 Op 3.36 ± 2.6 TR 65.7 ± 56.0 615 lost COGs Core of lost genes Metabolism Cellular processes ↑ Atypical rDNA operon ↓ Growth rate
Genome sequencing and analysis
In point of care for diagnostic and treatment POC Timone Senegal Molecular diagnostic
Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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  • 5. Tools  Culture- introducing culturomics
  • 6.  
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  • 8. Free-living bacterial community Merhej V, et al. Biol Direct . 2009 Apr 10;4:13. 264 lost COGs Facultative host-associated Bacteria GS 2.92 ± 1.6 GC 43.0 ± 11.7 Op 3.36 ± 2.6 TR 65.7 ± 56.0 615 lost COGs Core of lost genes Metabolism Cellular processes ↑ Atypical rDNA operon ↓ Growth rate
  • 10. In point of care for diagnostic and treatment POC Timone Senegal Molecular diagnostic
  • 11.