Medical data and text mining: Linking diseases, drugs, and adverse reactions
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Medical data and text mining: Linking diseases, drugs, and adverse reactions
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Medical data and text mining: Linking diseases, drugs, and adverse reactions
- 1. Medical data and text mining Linking diseases, drugs, and adverse reactions Lars Juhl Jensen
- 3. Jensen et al., Nature Reviews Genetics, 2012
- 9. opt-out
- 10. opt-in
- 13. CPR number
- 15. Jensen et al., Nature Reviews Genetics, 2012
- 17. 14 years
- 22. ICD-10
- 23. Jensen et al., Nature Reviews Genetics, 2012
- 24. not research
- 25. reimbursement
- 27. naïve approach
- 28. comorbidity
- 29. Jensen et al., Nature Reviews Genetics, 2012
- 31. “known knowns”
- 32. gender
- 33. age
- 34. type of hospital encounter
- 35. Jensen et al., Nature Communications, 2014
- 36. “known unknowns”
- 37. smoking
- 38. diet
- 40. reporting biases
- 41. matched controls
- 43. multiple testing
- 44. trajectories
- 45. Jensen et al., Nature Communications, 2014
- 47. Jensen et al., Nature Communications, 2014
- 48. key diagnoses
- 49. Jensen et al., Nature Communications, 2014
- 52. structured data
- 53. Jensen et al., Nature Reviews Genetics, 2012
- 56. free text
- 57. Danish
- 58. busy doctors
- 59. typos
- 61. text mining
- 62. computer
- 63. as smart as a dog
- 64. teach it specific tricks
- 68. diseases
- 69. drugs
- 71. expansion rules
- 72. Clozapine
- 73. Clozapine clozapi n clossapi n klozapin e chlosapi n chlozapi chlosapi ne n chlozapi ne klossapi n closapin e klozapi klosapi n n
- 75. compound nouns
- 78. kidney failure
- 79. “black list”
- 82. clinical trials
- 85. underreporting
- 86. data mining
- 87. structured data
- 88. medication
- 90. drug indications
- 91. known ADRs
- 96. Drug introduction Adverse event Drug discontinuation Negative modifier Indication Pre-existing Adverse event Eriksson et al., Drug Safety, 2014 condition Adverse drug reaction Possible adverse drug reaction ADR of additional drug
- 97. Drug introduction Identification star t Adverse event Drug discontinuation Negative modifier Indication Pre-existing Adverse event Eriksson et al., Drug Safety, 2014 condition Adverse drug reaction Possible adverse drug reaction ADR of additional drug
- 98. Drug introduction Drug discontinuation Negative modifier Indication Pre-existing Adverse event Eriksson et al., Drug Safety, 2014 condition Adverse drug reaction Possible adverse drug reaction Adverse event ADR of additional drug Identification star t
- 99. Drug introduction Drug discontinuation Negative modifier Indication Pre-existing Adverse event Eriksson et al., Drug Safety, 2014 condition Adverse drug reaction Possible adverse drug reaction Adverse event ADR of additional drug Identification star t
- 100. recall known ADRs
- 102. Eriksson et al., Drug Safety, 2014
- 103. discover new ADRs
- 104. Drug substance ADE p-value Chlordiazepoxide Nystagmus 4.0e-8 Simvastatin Personality changes 8.4e-8 Dipyridamole Visual impairment 4.4e-4 Citalopram Psychosis 8.8e-4 Bendroflumethiazi Apoplexy 8.5e-3 de Eriksson et al., Drug Safety, 2014
- 105. Acknowledgments Disease trajectories Anders Bøck Jensen Tudor Oprea Pope Moseley Søren Brunak Adverse drug reactions Robert Eriksson Thomas Werge Søren Brunak EHR text mining Peter Bjødstrup Jensen Robert Eriksson Henriette Schmock Francisco S. Roque Anders Juul Marlene Dalgaard Massimo Andreatta Sune Frankild Eva Roitmann Thomas Hansen Karen Søeby Søren Bredkjær Thomas Werge Søren Brunak