Powerpoint_design_for_Skin_care_company
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Powerpoint_design_for_Skin_care_company
- 1. Anti-Aging Skin Care Regimen Effective Products - Effective Delivery - Effective Sun Care 01
- 2. Basic skin structure The problem: skin aging The solution: skin regeneration by Derma-Lucia products How: the mechanism of Derma-Lucia - Neuro-peptides innovation: Neo-Endorphins and caffeic acid - NP-7 peptide complex and Hyaluronan function - Nano-Biotechnology innovation: Deeper penetration Phyto Stem cell induction Summary: Uniqueness of Derma-Lucia formulas Why Derma-Lucia Core Products? The Complete Derma-Lucia Regimen 02
- 3. 03
- 5. Fibroblasts are embedded in the ECM (extracellular matrix) Skin stem cells Epidermis Hypodermis Dermis 05
- 6. Epidermis Hypodermis Dermis H2O H2O H2O H2O H2O H2O H2OH2O H2O H2O • Dermis layer is build of fibroblasts embedded in the ECM (extracellular matrix) • Fibroblasts secrete ECM- building molecules: – Collagen – Elastin – Hyaluronan • Stem cells found in the dermis are important to replenish the aging fibroblasts 06
- 7. The skin is closely associated with the nervous system Skin cells contain receptors that can be activated by various stimuli such as chemical signals secreted by the brain and nerve cells, endocrine organs and immune system or the mechanical stimuli such as touch Skin function is under the tight control of neuronal, endocrine and immune systems 07 Roosterman D et al. Physiol Rev 2006;86:1309-1379
- 8. Neuro-peptides are secreted from the nerve cells Skin cells respond to the stimulation by neuro- peptides Neuro-peptides bind to specific receptors present in skin cells and activate gene expression programs 08 Roosterman D et al. Physiol Rev 2006;86:1309-1379
- 9. (The Anti-Aging Agents) • Neo-Endorphins belong to neuro-peptides and their function is to promote the wound healing and tissue repair in the damaged skin. • This unique function lies at the basis of the anti-wrinkle effect of neo-endorphins on the aged skin. 09
- 10. (Stimulate Stem Cells and Fibroblasts) Neo-endorphins • Neo-endorphins bind to the receptors in skin cells • Upon binding to the receptors, signaling cascades are induced that lead to gene expression programs ultimately stimulating cell proliferation, survival and activity 10
- 11. • Functional neuro-peptides that stimulate stem cells and fibroblasts • Active stem cells that replenish the pool of fibroblasts • Active fibroblasts that secrete ECM components: – Collagen provides plumpness and rigidity – Elastin ensures elasticity and resilience – Hyaluronan facilitates water retention and skin hydration To maintain the youthful skin appearance the following factors are essential: 11
- 12. (What Happens in the Aged Skin?) H2O H2O H2O H2O H2O H2O H2O H2O H2OH2O Abundance of neuro-peptides that stimulate stem cells and activate fibroblasts (production of the ECM components providing rigidity and elasticity) and plenty of water molecules to ensure hydration. Young skin Aged skin 12 Lowered neuro-peptides production, loss of stem cells and the fibroblasts activity, (hence lowering the collagen and elastin secretion) and further loss of hyaluronan production results in the reduced elasticity and hydration.
- 13. (Stem Cells and Fibroblasts in The Aged Skin) The pool of stem cells in the aged skin is exhausted . These stem cells are less efficient in dividing, proliferating and differentiating into new fibroblasts. As a consequence, less fibroblasts. are available to produce ECM components. Stem cells and fibroblasts in the aged skin are either sluggish or not active. It is essential to supply neuro- peptides that will activate stem cells and fibroblasts to propagate skin regeneration mechanism. 13
- 14. (How to Regenerate Matured Skin?) 1. By supplying the unique pool of neuro-peptides that will activate skin stem cells and fibroblasts => fibroblasts renewal complemented by wound healing process 2. By restoring collagen and elastin production => Skin elasticity and resilience restoration 3. By increasing water retention with hyaluronan groups 4. By incorporating Nanoparticles to enhance stability and deeper delivery of the active ingredients 5. By plant callus –phyto stem cell induction to work synergistically Why Derma-Lucia? Derma-Lucia unique formula provides a solution for skin regeneration. 14
- 15. (Active Components Lead to Skin Restoration) • Alpha-neo-endorphin • Caffeoyl-alpha-neo- endorphin • Caffeoyl-Tripeptide • Caffeoyl-Octapeptide • Caffeoyl-Decapeptide Neuro-peptides used in Derma-Lucia formula include a carefully-balanced combination of: 1. Regeneration => Neo-endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration. 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function. 3. Hydration => water retention by Hyaluronan group, supplemented with phyto stem cell –plant cell callus. 15
- 16. (Neo-Endorphins+ Caffeic Acid Restore Skin Integrity) Neo-endorphins• Neo-endorphins act most efficient when combined with caffeic acid. • Stem Cells serve as a source for generating new active fibroblasts. • Active fibroblasts secrete ECM components more efficiently. • Caffeic acid protects metabolically active cells from oxidative damage. 16
- 17. (Neo-Endorphins Initiate Signaling Events) Neo-endorphins 1) Neo-endorphin binding to its receptor => 2) Triggers the activation of biochemical signaling events that include protein phosphorylation, protein conformational changes and protein subcellular relocation => 3) Leading to gene regulation processes in the cell nucleus. Mechanism of neo-endorphin action: 17
- 18. (Restoring Elasticity and Resilience) Caffeoyl Tripeptide-1 Octapeptide-4 Decapeptide-7 Pentapeptide-19 Oligopeptide-28 Acetyl Hexapeptide-22 Acetyl Hexapeptide-8 NP-7 peptide complex contains: 1. Regeneration => Neo- endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function 3. Hydration => water retention by Hyaluronan group + Phyto stem cells 18
- 19. (Restoring Hydration) Hyaluronan group belongs to GAGs (glycosamin-glycans, the sugars). Hyaluronan can retain the amount of water 1000 times of its weight. 1. Regeneration => Neo- endorphin complex together with caffeic acid stimulate and activate skin stem cells and fibroblasts propagating skin restoration 2. Elasticity and resilience => collagen and elastin production+enhancement through NP-7 peptide complex function 3. Hydration => water retention by Hyaluronan group + Phyto stem cell 19
- 20. (Through Derma –Lucia Innovations) Anti-Aging and Anti-Wrinkle regimen of Derma-Lucia relies on the unique formula combining several active groups, each of which is responsible for a distinct action towards skin regeneration - Fibroblasts renewal - Wound healing process - Anti-oxidant protection Collagen and elastin restoration Hydration 20
- 21. (Derma –Lucia Innovation) Skin restored Wound healing effect enhanced by the roller treatment Nanoparticle encapsulation; proprietary vitamin and herbal complex, plant stem cells, natural oils Neo-Endorphin Complex with various peptide groups provide most effective anti-inflammatory, anti-wrinkle and anti-oxidant effect NP-7 Peptide complex Hyaluronan groups Collagen and elastin Restoration + hydration Rapid cell renewal Anti- oxidants Stem cell proliferation 21
- 22. Roller massaging provides physical stimulation to prepare the skin surface. Roller introduces epidermal micro-punctures preparing the skin for efficient response to the Derma-Lucia treatment. Roller application enhances the wound healing process, providing a more efficient delivery conduit 22
- 23. • Neuropeptide stimulation…… through => stem cell division/proliferation, wound healing process, anti-oxidant protection, anti-inflammatory and anti-wrinkle effect. • NP7-peptide complex induced collagen and elastin restoration => plumpness • Phyto Stem Cells – plant callus induction • Hyaluronan-mediated hydration => smoothness and anti- wrinkle effect. • Proprietary technological driven processing steps for deeper penetration. • Nano-Particles Innovation to achieve maximum stability of the active components for further absorption 23
- 24. 24 1. Super Aqua Toner Prep 2. Anti-Wrinkle Serum 3. Restorative Wrinkle & Eye treatment 4. Super Aqua Emulsion 5. Double Nourishing Sealer Core Products: Why Derma-Lucia Core Products? Patented proprietary anti-aging actives currently not available in America / Europe One of the highest active concentrations… working synergistically together Unique actives developed specific for anti-aging R & D, one of its kind. Infusion of Phyto stem cells –plant cell callus Anti-Aging Regimen combining Effective (Products + Delivery +Sun protection)
- 25. 25
Editor's Notes
- A symphony for youthful skin A symphony for young skin A symphony for healthy skin
- The talk outline.
- Message: define the key parameters that are responsible for skin youthful appearance and what goes wrong with age What the perfect skin is Modifications needed
- Describe the different layers of the skin and the role of each layer in skin integrity and function (good look is not only good for the beauty but it is also important for a general health) Describe the importance of each of the layers: hypodermis: nutrients, dermis: supportive, hydrating. Epidermis: protective As you know, the skin is divided into three basic layers: epidermis, dermis and hypodermis and each layer has a distinct function in skin integrity maintenance
- Message: Dermis is fibroblasts embedded in ECM, the molecules that they secrete ECM consists of collagen, elastin and GAGs (such as hyaluronan_
- Message: Dermis is fibroblasts embedded in ECM, the molecules that they secrete ECM consists of collagen, elastin and GAGs (such as hyaluronan_
- Message: introduce the concept of stem cells in the skin
- What is interesting for us that stem cells can differentiate into fibroblasts
- Lets look more closely at the MSC and see what they do.
- Explain what happens in the dermis - draw collage, elastin and hyaluronan. These molecules are essential to maintain skin elasticity, resilience and plumpness Explain what GAGs are
- Message: define the key parameters that are responsible for skin youthful appearance and what goes wrong with age Modifications needed: show the loss of the collagen, elastin, and hyaluronan. Replace the molecules
- Message: introduce the concept of stem cells in the skin
- Message: raise the question: how do we restore the old skin? We have to do three different things: There are stem cells that are present in our skin and they are the key for regeneration Modifications needed stem cells are present in the dermis:
- Message: what is conditioned MSC media. How is it prepared. What is contains, what is does to other MSCs (explain how the media is prepared) Add the liquid and the molecules secreted by the cells. Conditioned MSCs media is prepared by incubating the media on MSCs isolate from bone marrow of healthy donors Conditioned MSC media contains chemokines and growth factors These active components of MSCs media have beneficial effects on skin
- What is interesting for us that stem cells can differentiate into fibroblasts
- What is interesting for us that stem cells can differentiate into fibroblasts
- Put the peptide information
- Message: define the key parameters that are responsible for skin youthful appearance and what goes wrong with age Modifications needed
- Message: explain the unique potential of Derma-Lucia products to address each step required for skin regeneration. The triple effect of the DermaLucia products is achieved by: MSC conditioned media components that activate stem cells to proliferate and replace the old cells thus regenerating the aged skin. 2. NP-7 peptide complex that promotes collagen synthesis by the skin fibroblasts, thus eliminating the wrinkles and restoring the smoothness of the skin. 3. HA, which facilitates water retention resulting in the smooth appearance and plumpness of the skin.
- Message: explain the unique potential of Derma-Lucia products to address each step required for skin regeneration. The triple effect of the Derma Lucia products is achieved by: MSC conditioned media components that activate stem cells to proliferate and replace the old cells thus regenerating the aged skin. 2. NP-7 peptide complex that promotes collagen synthesis by the skin fibroblasts, thus eliminating the wrinkles and restoring the smoothness of the skin. 3. HA, which facilitates water retention resulting in the smooth appearance and plumpness of the skin.
- Message: what is conditioned MSC media. How is it prepared. What is contains, what is does to other MSCs (explain how the media is prepared) Add the liquid and the molecules secreted by the cells. Conditioned MSCs media is prepared by incubating the media on MSCs isolate from bone marrow of healthy donors Conditioned MSC media contains chemokines and growth factors These active components of MSCs media have beneficial effects on skin
- The talk outline.