Anais do Simpósio Internacional em Ciências Farmacêuticas Natal/RN

1. Annals
Of

2. 2011 Symposium Organizing Committee
Presidents
Dr. Arnóbio Antônio da Silva Júnior, UFRN/RN
Dra. Maria das Graças Almeida, UFRN/RN
Executive Committee
Dra. Adriana Augusto de Rezende, UFRN/RN
Dra. Aline Schwarz, UFRN/RN
Dra. Ana Paula Barreto Gomes, UFRN/RN
Dra. Ivanise Marina Moretti Rebecchi, UFRN/RN
Dra. Janaína C. de Oliveira Crispim Freitas, UFRN/RN
Dr. Guilherme Maranhão Chaves, UFRN/RN
Dra. Lúcia Maria da Cunha Galvão, UFRN/RN
Scientific Committee
Dr. Anselmo Gomes de Oliveira, UNESP/SP
Dr. Egler Chiari, UFMG/MG
Dr. Eryvaldo Sócrates Tabosa do Egito, UFRN/RN
Dr. Luiz Alberto Lira Soares, UFPE/PE
Dr. Mario Hiroyuki Hirata, USP/SP
Dr. Matheus de Freitas Fernandes Pedrosa, UFRN/RN
Dra. Raquel Brandt Giordanni, UFRN/RN
Dra. Silvana Zucolotto Langassner, UFRN/RN
Dra. Vivian Nogueira Silbiger, UFRN/RN
Scientific Evaluation Committee
Dr. Bolívar P.G.L. Damasceno, UEPB-CG/PB
Dr. Cícero Flávio Soares Aragão, UFRN/RN
Dra. Cristiane C.G.O. Lopes, UFC/CE
Dra. Francilene Amaral da Silva, UFS/SE
Dr. Lívio César Cunha Nunes, UFPI/PI
Dr. José Alexsandro da Silva, UEPB-CG/PB
Dr. José Otávio Carréra Silva Júnior, UFPA/PA
Dra. Júlia Beatriz Pereira de Souza, UFCG-CG/PB
Dr. Najeh Maissar Khalil, UNICENTRO/PR
Dra. Paula da Silva Kujbida, UFRN/RN
Dr. Rand Randall Martins, UFCG-CG/PB
Dr. Toshiyuki Nagashima Júnior, UFCG-CG/PB
Dr. Geraldo Barroso Cavalcanti Júnior, UFRN/RN
Dra. Antônia Claudia, UFRN/RN
Dr.Túlio Moura, UFRN/RN
Dr. Anselmo Oliveira Gomes, UNESP/SP
Dr. Mário Hiroyuki Hirata, USP/SP
Dr. Luiz Alberto Lira Soares, UFPE/PE
Dr. Matheus de Freitas Fernandes Pedrosa, UFRN/RN
Dra. Raquel Brandt Giordanni, UFRN/RN
Dra. Silvana Zucolloto Langassner, UFRN/RN
Dra. Vivian Nogueira Silbiger, UFRN/RN
Dra. Julieta Genre, UFRN/RN
Dra. Paula Machado, UFRN/RN
Dra. Maria Joselice, UFRN/RN
Dr. Euzébio Guimarães Barbosa, UFRN/RN

3. Student Organizing Committee
Alessandro Brito dos Santos (Undergradute Pharmacy student-UFRN)
Alice Rodrigues de Oliveira (graduate student-PPGCF-UFRN)
Andréa Caroline Costa de Arruda (Undergradute Pharmacy student-UFRN)
Clélio Diogo Soares (graduate student-PPGCF-UFRN)
Cristhiano Sibaldo (graduate student-PPGCF-UFRN)
Daliana Maria Berenice de Oliveira Souza (graduate student-PPGCF-UFRN)
Elyson Diego Salustino Saravia Osorio (Undergradute Pharmacy student-UFRN)
Emerson Michell da Silva Siqueira (Undergradute Pharmacy student-UFRN)
Fabiana Paiva Galvão (graduate student-PPGCF-UFRN)
Francisco Humberto Xavier Júnior (graduate student-PPGCF-UFRN)
Gabriel Araujo da Silva (graduate student-PPGCF-UFRN)
Heglayne Pereira Vital da Silva (graduate student-PPGCF-UFRN)
Ipojucan Silva Fontes (Undergradute Pharmacy student-UFRN)
Jahamunna Abrantes Andrade Barbosa (graduate student-PPGCF-UFRN)
Janaina da Silva Goes (graduate student-PPGCF-UFRN)
Julia Morais Fernandes (Undergradute Pharmacy student-UFRN)
Juliana F. Carvalho (graduate student-PPGCF-UFRN)
Juliana Félix Da Silva (Undergradute Pharmacy student-UFRN)
Julieta Genre (graduate student-PPGCF-UFRN)
Karla Samara Rocha Soares (graduate student-PPGCF-UFRN)
Karla Simone Costa de Souza (graduate student-PPGCF-UFRN)
Layany Carolyny da Silva Mourão (graduate student-PPGCF-UFRN)
Leandro Vinicius Fernandes de Morais (Undergradute Pharmacy student-UFRN)
Letícia Streck (graduate student-PPGCF-UFRN)
Lidyane Neves Miranda (graduate student-PPGCF-UFRN)
Margarete Moreno de Araujo (graduate student-PPGCF-UFRN)
Monique Christine Salgado Gomes (graduate student-PPGCF-UFRN)
Patrícia Fernandes Barbosa (Undergradute Pharmacy student-UFRN)
Polyanne Nunes de Melo (graduate student-PPGCF-UFRN)
Rafaela de Melo Pereira (graduate student-PPGCF-UFRN)
Rayllan de Oliveira Rodrigues (Undergradute Pharmacy student-UFRN)
Vitor Luiz de Brito Lemos (Undergradute Pharmacy student-UFRN)
Waleska Rayane Dantas Bezerra de Medeiros (Undergradute Pharmacy student-UFRN)
Walicyranison Plinio da Silva (graduate student-PPGCF-UFRN)
Wenna Gleyce Araújo do Nascimento (graduate student-PPGCF-UFRN)
Yamara Arruda Silva de Menezes (graduate student-PPGCF-UFRN)
Yonara Monique da Costa Oliveira (graduate student-PPGCF-UFRN)

6. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnosis methods and pharmaceutical products
ABSTRACTS
CODE PARTICIPANT AUTHOR TITLE PAGE
IMMUNOPHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF HEMATOPOIETIC STEM CELLS AFTER
1 Paulo Ricardo Silva Pereira PEREIRA, PRS 1
MOBILIZATION IN MALNOURISHED MICE
IN VITRO ACARICIDAL AND CYTOTOXIC ACTIVITY OF AQUEOUS EXTRACTS OF AGAVE SISALANA PERRINE AND
2 Arthur Ladeira Macedo MACEDO, AL 2
FURCRAEA SELLOA K. KOCH
3 Renata C. Vasconcelos VASCONCELOS, RMC PRELIMARY STUDY OF BORNEOL SALICILATE ANTIINFLAMATORY ACTIVITY 3
Mônica Oliveira Da Silva
4 SIMOES MOS ESTIMATION OF CARDIOVASCULAR RISK BY THE FRAMINGHAM SCORE IN HYPERTENSIVE PATIENTS 4
Simões
CHARACTERIZATION OF A CATIONIC NANOEMULSION INTENDED TO GENE THERAPY AFTER STERILIZATION
5 André Leandro Silva SILVA, AL 5
PROCESSES
SV1: ONE POLYSACCHARIDE POPULATION FROM SARGASSUM VULGARE WITH ANTICOAGULANT AND
6 Celina Maria Pinto Guerra Dore CELINA M. P. G. DORE 6
ANTITHROMBOTIC ACTIONS AND THROMBIN INHIBITOR
7 Cíntia R. C. Porto PORTO, CRC ANTI-INFLAMMATORY AND ANTINOCICEPTIVE ACTIVITIES OF PHYLLANTHUS NIRURI L SPRAY-DRIED EXTRACT 7
DETERMINATION OF RALOXIFENE HYDROCHLORIDE USING ULTRAVIOLET SPECTROPHOTOMETRY AND LC
8 Fernanda Rodrigues Salazar SALAZAR, FR 8
STABILITY-INDICATING METHOD
Andressa Santa Brigida Da
10 SILVA, ASB AQUEOUS EXTRACT OF MIKANIA LINDLEYANA DC. PRESENTS POTENTIAL ANTI-INFLAMMATORY EFFECT 9
Silva
12 Ana Carolina Kogawa KOGAWA, A.C. DEVELOPMENT AND VALIDATION OF DOXYCYCLINE HYCLATE BY HPLC METHOD 10
STRATEGY FOR TREATMENT OF WATER, FEDERAL UNIVERSITY OF CAMPINA GRANDE / CENTER FOR
13 Anderson Angel Vieira Pinheiro PINHEIRO, A.A.V. 11
EDUCATION AND HEALTH-PB
Áurea Marcela De Souza
14 PEREIRA, A.M.S. ADVERSE EVENTS IDENTIFIED IN A HOSPITAL OF THE SENTINEL NETWORK 12
Pereira
15 Bárbara Coeli SILVA, B. C. O STANDARDIZATION OF TECHNIQUES FOR EVALUATION OF HEMATOPOIESIS IN MALNOURISHED MICE 13
16 Clarissa Nunes De Assis ASSIS, C. N. REFLECTIONS OF A CUSTODY CHAIN IN CENTER OF PHARMACEUTICAL EQUIVALENCE 14
NANOCOSMETICS IN PHOTOPROTECTION: DEVELOPMENT AND CHARACTERIZATION OF NANOPARTICLES
17 Débora Freitas Do Nascimento NASCIMENTO, D.F. 15
WITH SUNSCREENS
20 Margareth Linde Athayde ATHAYDE, M. L. ANTIMYCOBACTERIAL ACTIVITY OF THE FRACTIONS AND COMPOUNDS FROM SCUTIA BUXIFOLIA REISSEK 16
DIRECT INHIBITORY ACTION OF SULFATED POLYSACCHARIDES FROM RED SEAWEED HYPNEA MUSCIFORMIS
21.1 Monique Gabriela ALVES, M. G. C. F 17
ON THROMBIN ENZYMATIC ACTIVITY EVALUATED BY CHROMOGENIC SUBSTRATE ASSAY
INHIBITORY ACTION ON LIPID PEROXIDATION AND PROTECTIVE ACTIVITY ON H2O2-INDUCED HEMOLYSIS OF
21.2 Monique Gabriela ALVES. M. G. C. F 18
SULFATED POLYSACCHARIDES F1.0 FROM RED SEAWEED HYPNEA MUSCIFORMIS
NENHUM AUTOR
23 Nially Karen Morais Do Amaral SUBLINHADO
DETERMINATION OF ACIDITY IN CURD CHEESE OF CAICÓ AND JUCURUTU 19

7. 24 Adalgiza D. V. Silva SILVA. A. D. V. TOXICOLOGIC ASSAY OF ETHANOLIC EXTRACT FROM XYLOPIA CAYENNENSIS 20
Everton Do Nascimento
25 ALENCAR. E. N ANTIMICROBIAL ACTIVITY EVALUATION OF COPAIBA OIL MICROEMULSION SYSTEM: A PRELIMINARY STUDY 21
Alencar
Julius Roberto Martins De
26 OLIVEIRA. J. R. M. DE PROFILE AND QUALITY OF MEDICATIONS PRESCRIPTION IN THE CITY OF CUITÉ – PB. BRAZIL 22
Oliveira
NENHUM AUTOR
27.1 Mallone Lopes Da Silva SUBLINHADO
ANÁLISE FITOQUÍMICA E CROMATOGRÁFICA DE MIKANIA GLOMERATA 23
NENHUM AUTOR
27.2 Mallone Lopes Da Silva SUBLINHADO
INVESTIGATION OF METABOLITES FROM XYLOPIA CAYANNENSIS 24
28 Rosilene Rodrigues Santiago SANTIAGO. R. R. ZINC OXIDE EMULSION: A NEW ALTERNATIVE TO DIAPER DERMATITIS TREATMENT 25
LEGAL ANALYSIS OF MEDICINES ADVERTISING TRANSMITTED IN RADIO STATION FROM NATAL/RN
30 Almária Mariz Batista BATISTA. A. M. 26
ACCORDING TO RDC N° 96/08
STUDY OF ISONIAZID ADSORPTION ONTO CHITOSAN: ASSAYS OF EQUILIBRIUM AND KINETICS USING STIRRED
31.1 Rosalina Coelho Jácome JÁCOME. R. C 27
TANK
31.2 Rosalina Coelho Jácome JÁCOME. R. C HOUSEHOLD SURVEY ABOUT THE PROFILE OF DRUG USE BY ELDERLY IN THE CITY OF CUITÉ-PB 28
ORAL ADMINISTRATION OF EXTRACT CYANOBACTERIAL BLOOM IN PREGNANT RATS: A REPRODUCTION
32 Cristhiano Sibaldo ALMEIDA. C.S. 29
ASSESSMENT
Daisy Dayane Formiga De COMPARATIVE ANLYSIS OF PHYSICAL AND CHEMICAL PROPERTIES OF TWO SOURCES OF WATER FOR USE
33 LIMA. D.D.F.S 30
Souza Lima ON SCHOLL PHARMACY MANUEL CASADO ALMEIDA. CUITÉ-PB
34.1 Eliane Gandolpho Tótoli TÓTOLI. E. G. QUALITATIVE TESTS OF AMPICILLIN SODIUM POWDER FOR INJECTION 31
DEVELOPMENT AND VALIDATION OF TURBIDIMETRIC ASSAY TO POTENCY EVALUATION OF AMPICILLIN
34.2 Eliane Gandolpho Tótoli TÓTOLI. E. G. 32
SODIUM FOR INJECTION
TECHNICAL AND ADMINISTRATIVE MANAGEMENT OF SCHOOL PHARMACY'S WAREHOUSE MANOEL CASADO
35 Ivson Medeiros MEDEIROS JR. I. J. 33
DE ALMEIDA – UFCG/CES.
Jose Marcos Dos Santos VALIDATION OF A SPECTROPHOTOMETRIC METHOD (UV-VIS) FOR DETERMINATION OF TOTAL FLAVONOIDS OF
36 OLIVEIRA. J. M. S. 34
Oliveira THE RED PROPOLIS FROM ALAGOAS: USE OF CATECHIN AS BIOMARKER
37.1 Keine Monteiro Castro CASTRO K.M. CONSTITUENTS STUDY OF FIXED PIKE NORTHEAST ( CARYOCAR CORIACEUM WITTMER.) 35
GUIDANCE ON PHARMACEUTICAL PREPARATIONS MEDICINAL PLANTS WITHHOMEMADE: A STRATEGY
37.2 Keine Monteiro Castro CASTRO K.M. 36
FOR FAMILY HEALTH
STUDY OF THE TOXICITY OF ESSENTIAL OIL OF CYMBOPOGON CITRATUS (DC) STAF. FOR A POSSIBLE
38 Larice Brito De Vasconcelos VASCONCELOS. L. B. 37
APPLICATION AS ANTIFUNGAL DRUG
39.1 Luis Fabio Dos Santos Gomes GOMES.L.F.S. PRELIMINARY STUDY OF THE TOXICITY OF ASPIDOSPERMA EXCELSUM BENTH (APOCYNACEAE). 38
ACUTE ORAL TOXICITY EVALUATION OF THE DRY ETHANOLIC EXTRACT OF HIMATANTHUS ARTICULATUS AND
39.2 Luis Fabio Dos Santos Gomes GOMES.L.F.S. 39
ELEUTHERINE PLICATA

8. HISTOPATHOLOGICAL STUDIES OF THE EFFECTS OF THE AQUEOUS EXTRACT OF THE ORBIGNYA PHALERATA
40.1 Mayara Ladeira Coelho COÊLHO. M. L. 40
MART (BABASSU) MESOCARP POWDER IN ADULT MICE TREATED ORALLY
THERMAL CHARACTERIZATION OF BABASSU (ORBIGNYA PHALERATA MART) MESOCARP POWDER COMPARED
40.2 Mayara Ladeira Coelho COÊLHO. M. L. 41
WITH THE RAW MATERIAL MICROCRYSTALLINE CELLULOSE
Severina Denise Sales De NENHUM AUTOR
41 SUBLINHADO
STUDY AND CHARACTERIZATION SPECTROSCOPIC OF THE COMPLEX POTASSIUM HEXACYANOFERRATE 42
Oliveira
MEASUREMENT OF TOTAL FLAVONOIDS IN THE HYDROALCOHOLIC EXTRACTS OF RED PROPOLIS FROM
42 Tassia Tatianna Firmino FIRMINO. T.T.D. 43
ALAGOAS
COMPARISON OF METHODS FOR DETERMINATION OF CONTENT PROTEIN IN THE AQUEOUS AND ACETONE
43 Yohana Souza Pinto PINTO. Y.S. 44
EXTRACT ANNONA SQUAMOSA
PHYSICO-CHEMICAL PARAMETERS OF LANETTE® AND POLAWAX® EMULSIONS FOR “MANOEL CASADO DE
44 Alaine Maria Dos Santos Silva SILVA. A.M.S 45
ALMEIDA”/UFCG. PB PHARMACY SCHOOL PRODUCTION
MICROBIOLOGICAL ANALYSIS OF WATER FROM DIFFERENT SOURCES OF FORTALEZA IN THE PERIOD
45 Clarissa Nunes De Assis ASSIS. C. N 46
JANUARY TO SEPTEMBER 2011
UTILIZATION OF MG. AL LAYERED DOUBLE HYDROXIDES (LDHS) AS A CARRIER OF DIGOXINE FOR
46 Lisllie Dayse Araújo Santos SANTOS. L.D.A 47
VECTORIZATION IN CHEMOTERAPY OF CANCER
SILVA. LIVALDO COSTA
47 Livaldo Costa E Silva E
CREATION OF DIGITAL'S MAGAZINES ON RATIONAL USE OF DRUGS: NEW PERSPECTIVES ON EDUCATION 48
CHRONIC. BUT NOT ACUTE. ETHANOL WITHDRAWL AFTER CHRONIC CONSUMPTION PROMOTES DEPRESSIVE-
48 Marana Silveira Ali ALI. M.S. 49
LIKE BEHAVIOUR WITHOUT ALTERING LOCOMOTION IN RATS
APPLICATION OF THERMOANALYTICAL METHODS IN EVALUATING THE BEHAVIOR OF TUBERCULOSTATICS
49.1 Rayanne Karen Cunha Gurgel GURGEL. R. K. C 50
DRUGS PRODUCED BY NUPLAM / UFRN: ISONIAZID AND PYRAZINAMIDE
DETERMINATION OF PHYSICAL AND CHEMICAL COMPOSITION FOR THE QUALITY CONTROL OF MILK
49.2 Rayanne Karen Cunha Gurgel GURGEL. R. K. C 51
CONSUMED IN THE CITY OF NATAL / RN
Lorena Citó Lopes Resende STUDY OF PHYSICOCHEMICAL PROPERTIES AND ACUTE TOXICITY EVALUATION OF ETHANOLIC EXTRACT OF
50 SANTANA. LCLR. 52
Santana THE LEAVES FROM MIKANIA GLOMERATA SPRENGEL.
51 Nayara Maciel Mendonça MENDONÇA. N.M EPIDEMIOLOGY OF CANDIDEMIA IN PUBLIC HOSPITALS OF ALAGOAS. BRASIL 53
Andréia Cristina Wildner VALIDATION OF ANALYTHICAL METHODOLOGY FOR PASSIFLORA INCARNATA L. EXTRACT BY HPLC AND
52.1 WILDNER A. C. 54
Campos Lopes ANALYISIS OF COMMERCIALS EXTRACTS FROM RS
Andréia Cristina Wildner DEVELOPMENT AND VALIDATION OF A METHOD OF DISSOLUTION FOR DARIFENACIN EXTENDED-RELEASE
52.2 MENEGHINI. LC 55
Campos Lopes TABLETS BASED ON IN VIVO DATA
Luiza Sheyla Evenni Porfírio
53.1 WILL. L.S.E.P. LOBOPHORA VARIEGATA AND ITS ACTIVITY IN PAW EDEMA AND HEPATOTOXICITY IN RATS 56
Will
Luiza Sheyla Evenni Porfírio Β-GLUCANS OF CARIPIA MONTAGNEI MUSHROOM SHOWS ANTI-INFLAMMATORY ACTIVITY: NEWS
53.2 WILL. L.S.E.P. 57
Will PERSPECTIVE OF PPAR ATION
NENHUM AUTOR
54 Maria Tatiane Dias Moura SUBLINHADO
EVALUATION OF HYPOTENSIVE RESPONSES OF LYOPHILIZED AYAHUASCA TEA IN SHR RATS 58
55.1 Marilia Da Silva Nascimento NASCIMENTO. M.S. ANGIOGENESIS INHIBITION AND B-GLUCANS ANTITUMOR ACTION OF CARIPIA MONTAGNEI MUSHROOM 59

9. CARIPIA MONTAGNEI MUSHROOM B-GLUCANS SHOWING NON HEMOLYTIC ACTION AND ANTIOXIDANT
55.2 Marilia Da Silva Nascimento NASCIMENTO. M.S. 60
ACTIVITY: POTENTIAL FUNCTION IN LIPIDIC PEROXIDATION INHIBIT AND OXIDATIVE STRESS
NENHUM AUTOR
56 Luciane De Lira Teixeira SUBLINHADO
DETERMINATION OF MOISTURE AND LIPIDS IN FRUITS OF LICANIA TOMENTOSA BETH (OITI) 61
NENHUM AUTOR
57 Prycila Rodrigues Feitoza SUBLINHADO
EVALUATION OF THE CARDIOVASCULAR EFFECTS OF SYZIGIUM CUMINI SEEDS 62
58.1 Thuane De Sousa Pinheiro PINHEIRO. T.S. POLYSACCHARIDES EFFECTS FROM LOBOPHORA VARIEGATA IN A TOPICAL INFLAMMATORY MODEL 63
58.2 Thuane De Sousa Pinheiro PINHEIRO. T.S. ANTIOXIDANT ASSAYS OF BRUTE EXTRACTED FROM PLECTTRANTUS BARBATUS ANDR. 64
EVALUATION OF DENTIN ROUGHNESS AFTER USE OF DIFFERENTS CHELATING AGENTS EMPLOYED IN
59 T T SILVA JÚNIOR. J.O.C. 65
ENDODONTICS
TOPICAL APPLICATION OF PROPOLIS FOR HEALING OF WOUNDS SURGICALLY INDUCED AND EVALUATION OF
61 Mariana De Macedo Costa COSTA. M.M 66
BIOCHEMICAL PARAMETERS IN WISTAR RATS
62 Márcia Natália Da Silveira Pinto PINTO. M. N. S EVALUATION CYTOTOXIC IN VITRO OF NEW COMPOUND LPSF/MS-02 67
63 Roberta Da Silva Campos CAMPOS. R.S. DETERMINATION OF PROTEIN CONTENT OF ZIZYPHUS JOAZEIRO 68
Thales Allyrio Araújo De
64 FERNANDES. T.A.A.M. COMPARISON OF LABORATORY CHARACTERISTICS OF PATIENTS WITH SICKLE CELL DISEASE 69
Medeiros Fernandes
NENHUM AUTOR
65.1 Tahisa Marcela Pedroso SUBLINHADO
UV SPECTROPHOTOMETRIC PROFILE OF CEFAZOLIN SODIUM 70
NENHUM AUTOR A NEW. SAFE AND EASY METHOD OF THIN-LAYER CHROMATOGRAPHY FOR CEFAZOLIN SODIUM
65.2 Tahisa Marcela Pedroso SUBLINHADO
71
IDENTIFICATION
VOLTAGE-OPERATED POTASSIUM CHANNELS ARE INVOLVED IN (-)-BORNEOL-INDUCED VASORELAXANT
66 José Couras Silva Filho SILVA-FILHO. J. C. 72
RESPONSE ON RAT MESENTERIC ARTERY
67 Katyane Rodrigues RODRIGUES. K. PREPARATION OF NANOSTRUCTURED SYSTEMS SUNSCREENS ORGANIC – INORGANIC 73
68 Luíza Xavier XAVIER. L.A ANTIBACTERIAL EVALUATION OF NEW DERIVATIVES OF THIOPHENE 74
69 Camila Alves De Moura MOURA.C.A THEORETICAL AND PRACTICAL HANDBOOK: A TOOL FOR THE TRAINEESHIP LIVE PHARMACIES 75
Elyson Diego Salustino Saravia
70 OSORIO. E. D. S. S. DEVELOPMENT OF STRATEGIES OF MOLECULAR DIAGNOSTIC APPLIED TO DYSLIPIDEMIA 76
Osorio
EVALUATION OF THE ROLE OF THE NITRIC OXIDE IN GASTROPROTECTIVE ACTIVITY OF PARTITION
71 Flávia Danniele Frota Machado MACHADO. F.D.F FRACTIONS OF NEOGLAZIOVIA VARIEGATA MEZ. (BROMELIACEAE) IN MODEL OF ULCERS INDUCED BY 77
ETHANOL
72 Izadora De Souza DE SOUZA. I. OPTIMIZATION OF AN EXTRACTION PROCEDURE FOR THE BIOPOLYMER CHITIN 78

10. Danielle Cristina Zimmermann ZIMMERMANN- USE OF POTENTIALLY INAPPROPRIATE MEDICATIONS AND THE RISK OF POSSIBLE DRUG INTERACTIONS
73.1 FRANCO. D. C.
79
Franco BETWEEN INSTITUTIONALIZED FRAIL ELDERLY IN A CITY IN THE ZONA DA MATA MINEIRA
Danielle Cristina Zimmermann ZIMMERMANN- ANTIFUNGAL ACTIVITY OF OLEORESIN EXTRACTED FROM COPAIFERA LANGSDORFFII DESF AGAINST
73.2 FRANCO. D. C.
80
Franco DERMATOPHYTES FUNGI
EVALUATION OF ACCELERATED STABILITY OF SOYBEAN O/W EMULSION CONTAINING ETHANOL AND BENZYL
74 Margarete Moreno De Araujo DE ARAUJO. M. M. 81
ALCOHOL AS COSURFACTANTS
Mariana Araújo Paulo De EVALUATION OF MORPHOGENESIS AND PROTEINASE ACTIVITY OF CLINICAL ISOLATES OF C. ALBICANS
75 MEDEIROS. M. A. P 82
Medeiros OBTAINED FROM PATIENTS WITH VULVOVAGINAL CANDIDIASIS
76 Cristiane Franco Codevilla CODEVILLA C.F. DETERMINATION OF LODENAFIL CARBONATE USING CAPILLARY ZONE ELECTROPHORESIS METHOD 83
Melissa Alexandra Da Rosa ANALYSIS OF EPIDEMIOLOGICAL SITUATION OF LEPROSY IN CHILDREN UNDER 15 YEARS OLD IN FORTALEZA
77 COSTA. M .A. R. 84
Costa IN THE PERIOD OF 2001 TO 2010
78.1 Érika Yoko Suzuki SUZUKI. E.Y IN VITRO INHIBITION OF CLINICAL PSEUDOMONAS AERUGINOSA ADHESION BY XYLITOL 85
78.2 Érika Yoko Suzuki SUZUKI. E.Y ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL FROM BACCHARIS TRIMERA (LESS) DC 86
80 Daiane Soares SOARES. D.S PHYSICAL-CHEMICAL COMPATIBILITY BETWEEN ATTAPULGITE. RIFAMPICIN AND ISONIAZID 87
NEW METHOD TO PRODUCE XYLAN MICROPARTICLES USING SODIUM TRIMETAPHOSPHATE AS CROSS-
81 Elquio Eleamen Oliveira MARCELINO. H. R. 88
LINKING AGENT
82 Jéssica Guedes GUEDES. J. S. SYNTHESIS OF TIN (IV) COMPLEXES WITH POTENTIAL ANTIMICROBIAL ACTIVITY 89
Jôseffer Wianey Trindade
83 MEDEIROS. J. W. T. ADVERSE DRUG REACTIONS AS A CAUSE OF HOSPITAL ADMISSION 90
Medeiros
ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS LEAF EXTRACT OF JATROPHA GOSSYPIIFOLIA L. IN
84.1 Juliana Félix Da Silva FÉLIX-SILVA. J 91
CARRAGEENIN-INDUCED PAW EDEMA IN RATS
ANTI-INFLAMMATORY ACTIVITY OF BULLFROG (RANA CATESBEIANA) OIL IN CARRAGEENIN INDUCED PAW
84.2 Juliana Félix Da Silva FÉLIX-SILVA. J 92
EDEMA IN RATS
86 Maria Luiza Gois Campos CAMPOS. M. L. G INCLUSION COMPLEXES OF FUROSEMIDE WITH Β-CYCLODEXTRIN AND PVP 93
Nathália Alexandra De Oliveira
87.1 CARTAXO. N.A.DE O. RATIONAL USE OF DRUGS IN HYPERTENSION: AN ACHIEVEMENT OF PHARMACEUTICAL CARE 94
Cartaxo
Nathália Alexandra De Oliveira EXTRACTION OF FLAVONOIDS AND POLYPHENOLS IN LEAVES OF MENTHA X PIPERITA L. PROCESSED IN
87.2 CARTAXO. N.A.DE O. 95
Cartaxo FIXED BED CONVECTIVE DRYER
Andressa Noronha Barbosa Da DISTRIBUTION OF TRIATOMINES FAUNA AND NATURAL INFECTION BY TRYPANOSOMA CRUZI IN THE SEMIARID
90 SILVA. A. N. B. 96
Silva OF THE STATE OF RIO GRANDE DO NORTE. BRAZIL
91 Michelle De Oliveira Pedrosa PEDROSA. M.O. DEVELOPMENT OF THIOPHENES DERIVATIVES BIOCOMPATIBLES MICROEMULSIONS 97
92 Karolyne Dos Santos Silva SILVA. K. S INFLUENCE OF PLURONIC® F68 ON THE BENZATHINE PENICILLIN G ANTIBACTERIAL ACTIVITY 98

11. Máyra Furtado Dias Filgueira EVALUATION OF THE ANTIFUNGAL ACTIVITY OF NOR-LAPACHONE DERIVATIVE AGAINST ISOLATES OF
93 THÉ. M. F. D. F. 99
Thé CANDIDA SPP.
Jacyra Antunes Dos Santos QUALITATIVE PHYTOCHEMICAL PROFILE OF JATROPHA GOSSYPIIFOLIA L. EXTRACTS PREPARED BY
94 GOMES. J. A. S. 100
Gomes DIFFERENT METHODS OF EXTRACTION
Magda Rhayanny Assunção EVALUATION OF ANTIFUNGAL ACTIVITY OF CRUDE EXTRACT FROM CAESALPINIA FERREA MART AGAINST
95.1 FERREIRA. M. R. A 101
Ferreira CLINICAL ISOLATES FROM THE ORAL CAVITY OF RENAL TRANSPLANTATION
Magda Rhayanny Assunção BIOASSAY-GUIDED PURIFICATION OF CRUDE EXTRACT FROM STEM BARKS FROM CAESALPINIA FERREA
95.2 FERREIRA. M. R. A 102
Ferreira MART (PAU FERRO)
IDENTIFICATION AND PHOSPHOLIPASE ACTIVITY OF FUNGI ISOLATED FROM DERMATOMYCOSES OF
96 Walicyranison Plinio Da Silva SILVA. W.P 103
CHILDREN ATTENDING MUNICIPAL CENTERS OF CHILDREN EDUCATION FROM NATAL-RN
97 Patrícia Barbosa BARBOSA. P.F. EVALUATION OF THE REPRODUCTIVE AND FETAL TOXICITY OF CYLINDROSPERMOPSIN IN THE RAT 104
Maria Aparecida Alves Leite DEVELOPMENT OF A LIQUID DETERGENT FORMULATION FOR USE IN UFCG/CES AND EVALUATION OF
98.1 ALMEIDA. M.A.A.L.S 105
Dos Santos Almeida VISCOSITY AND POWER FOAM
Maria Aparecida Alves Leite RETROSPECTIVE STUDY OF ADVERSE DRUG REACTIONS IN THE PEDIATRIC WARD OF THE UNIVERSITY
98.2 ALMEIDA. M.A.A.L.S 106
Dos Santos Almeida HOSPITAL ALCIDES CARNEIRO. CAMPINA GRANDE / PB
99 Alexandre Medeiros Dantas OLIVEIRA. A. R. IN VITRO RELEASE OF METHOTREXATE-LOADEDSPRAY DRIED PLGA MICROPARTICLES 107
101 Letícia Streck STRECK. L. BENZNIDAZOLE-LOADED SOYBEAN O/W EMULSION SYSTEM 108
NENHUM AUTOR EVALUATION OF CITRONELLA (CYMBOPOGON WINTERIANUS JOWITT EX BOR.) OIL COMPOSITION EXTRACTED
102 Milene Evelyn Da Silva SUBLINHADO
109
FRESH AND DRY PLANT AND INFLUENCE OF HARVESTING PERIOD
SCREENING FOR ANTIBACTERIAL ACTIVITY ANTIMICROBIAL ACTIVITY OF HYDROALCOHOLIC EXTRACT OF
Cynthia Layse Ferreira De
103 ALMEIDA. C. L. F. ANADENANTHERA MACROCARPA BENTH AND MYRACODRUOM URUNDEUVA ALL. AGAINST STRAIN OF 110
Almeida
STAPHYLOCOCCUS AUREUS
104 Anne Kaliery De Abreu Alves ALVES. A.K.A. OUABAIN REDUCES THE PHAGOCYTOSIS OF PERITONEAL MACROPHAGES 111
NENHUM AUTOR EVALUATION OF THE RELAXING ACTIVITY OF ETHANOL EXTRATCT FROM LEAVES ASPIDOSPERMA
105 Manuelle Prestrelo De Oliveira SUBLINHADO
112
MACROCARPUM IN ISOLATED RAT MESENTERIC ARTERY
106 Luis Paulo Da Penha Ferino FERINO. L.P.P. EVALUATION OF TESTS PRE-TRANSFUSIONAL IMMUNO-HEMATOLOGICAL IN RECEPTORS OF BLOOD 113
DEVELOPMENT AND VALIDATION OF A REVERSED-PHASE LIQUID CHROMATOGRAPHY METHOD FOR THE
107 Ricardo Bizogne Souto SOUTO R. B. 114
EVALUATION OF RECOMBINANT HUMAN INTERLEUKIN-11. CORRELATION WITH THE BIOASSAY
STUDY OF A RP-LC METHOD FOR THE ANALYSIS OF RECOMBINANT PARATHYROID HORMONE IN
108 Fernanda Pavani Stamm STAMM. F. P 115
BIOPHARMACEUTICAL FORMULATIONS
EFFECT OF TRIETHANOLAMINE/METHYL-1-PYRROLIDONE-2/BETACYCLODEXTRIN MULTICOMPONENT
109 Polyanne Nunes De Melo MELO. P. N. 116
COMPLEXES SYSTEMS ON THE BENZNIDAZOLE APPARENT SOLUBILITY
PHYSICAL PARAMETERS OF QUALITY ASSESSMENT OF DIFFERENT LOTS OF HOMEOPATHIC GLOBULES IN
111.1 Carolina Moraes Cabé CABÉ. C. M 117
USE IN NATAL /RN/BRAZIL

12. 111.2 Carolina Moraes Cabé CABÉ. C. M SPECTRAL ANALYSIS (FT-IR. UV) OF RELEASE OF LEACHABLES FROM NATURAL RUBBER BULBS 118
Horacinna Maria De Medeiros
112 CAVALCANTE. H. M. M. TOXICITY OF DENTAL VARNISH CHITOSAN 119
Cavalcante
NEW TALENT PROGRAM – EDUCATION FOR HEALTH – ANALYSIS AND EDUCATION IN WATER USE IN THE OF
113 Edeildo Ferreira SILVA JÚNIOR. E. F. 120
TRAIPU – ALAGOAS
Katharina Rodrigues De Lima
114 RAMOS. K. R. L. P. EVALUATION OF THE CARDIOVASULAR RISK IN CONNECTION TO C-REACTIVE PROTEIN 121
Porto Ramos
Antônio Vinícius Doriguetto CHEMICAL PROFILE VERIFICATION OF THE EXTRACTS AND SEMI-PURIFIED FRACTIONS OF ANDIRA NITIDA
115 FERREIRA. A. V. D 122
Ferreira MART. EX BENTH BY TLC
Leonardo Augusto Rêgo De NENHUM AUTOR
116 SUBLINHADO
PRO-INFLAMMATORY AND CYTOTOXIC ACTION CARRAGEENAN OF THE SEAWEED AMANSIA MULTIFIDA 123
Souza
117.1 Geovani Pereira Guimarães GUIMARÃES. G. P ANTIFUNGAL ACTIVITY OF MEDICINAL PLANTS AGAINST CANDIDA SPECIES 124
117.2 Geovani Pereira Guimarães GUIMARÃES. G. P DEVELOPMENT OF A LSVM-5CN05 TRANSDERMIC MICROEMULSION 125
Mallu Hemmer Gomes De
118 MENEZES. M.H.G. ACUTE AND SUBACUTE TOXICITY OF CAESALPINIA FERREA STEM BARK EXTRACT 126
Menezes
Paula Regina Rodrigues ANTINOCICEPTIVE ACTIVITY OF CURINE ON THE ACETIC ACID ABDOMINAL CONSTRICTION TEST (WRITHING
119.1 SALGADO. P. R. R. 127
Salgado TEST) IN MICE
Paula Regina Rodrigues EVALUATION OF THE ANXIOLYTIC EFFECT OF ETHANOLIC EXTRACT OF SIDASTRUM MICRANTHUM
119.2 SALGADO. P. R. R. 128
Salgado (MALVACEAE) ON THE ELEVATED PLUS-MAZE TEST IN MICE.
SCANNING ELECTRON MICROSCOPY (SEM) / ENERGY-DISPERSIVE X-RAY SPECTROSCOPY (EDS) AS AN
122 Severino Antônio De Lima Neto VARGAS. M. R. W. DE 129
METHOD FOR THE CHARACTERIZATION OF MICROPARTICLES.
123 Gabriel Chaves Neto CHAVES NETO. G1 CLINICAL MODELS AND EVALUATION MEASURES IN THE STUDY OF EXPERIMENTAL ANXIETY 130
EVALUATION OF THE TYPE ACTION ANTIDEPRESSANT OF THE EXTRACT HYDROALCOHOLIC OF EUPATORIUM
125 Ademar Soares Melo MELO. A.S 131
AYAPANA VENT.
Yamara Arruda Silva De
126 MENEZES. Y. A. S.1 EXTRACTION. MEASUREMENT AND ANALYSIS OF TOTAL PROTEIN OF NATIVE PLANTS FROM RN 132
Menezes
128 Mayara Marilia Ferreira Limeira LIMEIRA. M.M.F. REPEAT-DOSE TOXICITY OF THE AQUEOUS EXTRACT OF CAESALPINIA FERREA STEM BARK 133
PRELIMINARY STUDIES FOR THE USE OF ARTIFICIAL NEURAL NETWORKS (ANN) IN THE STUDY OF RHEOLOGIC
129 Marco Navarro NAVARRO. M. V. M. 134
PROPERTIES OF TUBERCULOSTATICS AND SOLID EXCIPIENTS
GASTROPROTECTIVE EFFECTS OF ETHANOLIC EXTRACT FROM SPONDIA PURPUREA ON EXPERIMENTAL
130 Alexandre Medeiros Dantas DANTAS. A.M. 135
GASTRIC ULCER MODELS IN RODENTS
IMPACT ON HEMATOLOGICAL PARAMETERS OF L-ARGININE SUPPLEMENTATION IN PATIENTS WITH SICKLE
131 Romélia Pinheiro Gonçalves BANDEIRA. I.C.J 136
CELL ANEMIA IN USE OF HYDROXYUREA
ALTERAÇÕES HEMATOLÓGICAS EM CRIANÇAS COM TETRALOGIA DE FALLOT SUBMETIDAS À CIRURGIA
132 Izabel Cristina Justino Bandeira BANDEIRA. I.C.J 137
CARDÍACA COM CIRCULAÇÃO EXTRACORPÓREA

13. PROFILE OF PATIENTS WITH CHRONIC DISEASE NON-TRANSMISSIBLE PARTICIPANTS OF A PHARMACEUTICAL
133 Thiago Peixoto Rodrigues RODRIGUES. T.P 138
CARE PROGRAM
Gabriel Azevedo De Brito PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES BETWEEN CHLORPROPAMIDE AND Β-
134 DAMASCENO GAB 139
Damasceno CYCLODEXTRIN
Maria Aline Barros Fidelis De
135 MIRANDA. N. TOXICOLOGICAL PROFILE OF EMERGENCY ATTENDED AT VIÇOSA-AL HOSPITAL 140
Moura
DEVELOPMENT AND VALIDATION OF HPLC FAST METHOD FOR SIMULTANEOUS DETERMINATION OF NINE
136 Gabriel Araujo Da Silva ARAUJO-SILVA. G. 141
POLYPHENOLS COMPOUNDS IN CRUDE EXTRACTS OF PLANTS
APPLICATION OF DIFFERENTIAL THERMAL ANALYSIS (DTA) TO DETERMINE OF TRIOXSALEN-EXCIPIENT
137.1 Denise Michelle Costa Barros BARROS. D.M.C. 142
COMPATIBILITY
137.2 Denise Michelle Costa Barros BARROS. D.M.C. COMPATIBILITY STUDY OF VITAMIN D3 AND MANNITOL IN PHYSICAL MIXTURES 143
A QUANTUM STUDY OF DRUG-RECEPTOR INTERACTION: RECONHECENDO AS BINDING ENERGIES BETWEEN
138 Jonas Ivan Nobre Oliveira OLIVEIRA. J. I. N 144
16S RRNA RESIDUES AND HYGROMYCIN B
Yonara Monique Da Costa STUDY OF 599 C>T POLYMORPHISM OF THE GPX1 GENE IN TYPE 1 DIABETES: IMPLICATIONS IN ANTIOXIDANT
140 OLIVEIRA. Y.M.C 145
Oliveira DEFENSE AND DIABETIC NEPHROPATHY
141.1 Thereza Mylene PEREIRA. T. M. M PRELIMINARY STUDY FOR THERMAL CHARACTERIZATION OF BIOIDENTICAL HORMONE ESTRADIOL 146
LINEARITY IN DTA METHOD: A COMPARISON OF TWO QUANTIFICATION STRATEGIES OF BIOIDENTICAL
141.2 Thereza Mylene PEREIRA. T. M. M 147
HORMONE
142 Walteçá Louis Lima Da Silveira SILVEIRA. W. L. L. INTERFERENCE ON ADHERENCE OF CANDIDA SSP IN CONTACT LENSES BY MICROEMULSION SYSTEMS 148
143.1 Thays Oliveira OLIVEIRA. T.S. CHARACTERIZATION OF THERMAL EVENTS OF HYDROQUINONE DEPIGMENTANT BY DTA 149
143.2 Thays Oliveira OLIVEIRA. T.S. COMPATIBILITY STUDY OF TRETINOIN AND EMULSIFYING AGENT IN PHYSICAL MIXTURES 150
EVALUATION OF THE ANTINOCICEPTIVE EFFECT OF HYDROETANOLIC EXTRACT OF PORTULACA PILOSA L
144 Fabrício Alexopulos Ferreira MELO. A.S. 151
(PORTULACACEAE). IN MICE
EVALUATION OF PHYSICOCHEMICAL PROPERTIES OF POORLY WATER SOLUBLE DRUG (SIMVASTATIN)
145 Mara Rúbia Winter De Vargas VARGAS. M. R. W 152
OBTAINED BY RECRYSTALLIZATION
146 Erlhane Irineu Lourenço Silva SILVA; E.I.L ANALYSIS AND CHARACTERIZATION OF OILS AND FATS 153
Franklin Ferreira De Farias EVALUATION OF ANTIOXIDANT ACTIVITY IN SEASONAL STUDY OF PHASE ETHYL ACETATE BAUHINIA
148 NÓBREGA. F.F.F. 154
Nóbrega CHEILANTHA (BONG.) STEUDEL
Renata Cristina De Araujo
149.1 VALENÇA. R.C.A PHARMACEUTICAL ASSISTANCE THE ELDERLY: SHARES OF COMMUNITY INTERVENTION IN BRASILIA TEIMOSA 155
Valença
Renata Cristina De Araujo
149.2 VALENÇA. R.C.A PROTEIN ANALYSIS BY BRADFORD METHOD IN SAMPLES OF CEREAL 156
Valença
ANTIMICROBIAL ACTIVITY OF HYDROALCOHOLIC EXTRACT OF STRYPHNODENDRON ADSTRINGENS MART.
150 Gabriela Muniz Felix Araújo ARAÚJO. G. M. F. 157
AGAINST STRAIN OF STAPHYLOCOCCUS AUREUS

14. STUDIES OF MAGNETIC PARTICLES PREPARED BY CO-PRECIPITATION UNDER MAGNETIC FIELD FOR DRUG
151 Kátia Lira Da Silva SILVA. K. L. 158
DELIVERY
Jéssica Layanne Cabral
152 AZEVEDO. J. L. C A STRUCTURAL AND ENERGETIC INVESTIGATION OF PAROMOMYCIN-16S RRNA COMPLEX 159
Azevedo
SYNTHESIS AND CHARACTERIZATION OF AMOXICILLIN AND METRONIDAZOLE-BASED CHITOSAN
153 João Ricardo P. De Carvalho CARVALHO. J.R.P 160
MICROPARTICLES
154 Tulio Salgado SALGADO. T.M.M VISCERAL LEISHMANIASIS: SURVEY OF NOTIFIED CASES OF DISEASE IN THE CITY OF ASSU / RN 161
OZAWA CALCULATION APPLIED TO THE KINETIC STUDY OF DECOMPOSITION OF FLUCONAZOLE BY
156 Wendell M. De Azevedo. AZEVEDO. W. M. DE 162
THERMOGRAVIMETRY
157.1 Edilamar Pereira Da Silva SILVA E. P. THERMAL CHARACTERIZATION OF ALKALOID SYNTETIC WE014 BY TG/DTA AND DSC 163
157.2 Edilamar Pereira Da Silva GALVÃO. F. P DETERMINATION OF KINETIC PARAMETERS BY OZAWA OF ALKALOID SYNTETIC WE014 164
158 Rachel Ouvinha De Oliveira OLIVEIRA R. DEVELOPMENT OF GOLD NANOPARTICLES CONTAINING DOCETAXEL 165
EVALUATION IN VITRO OF SCHINUS TEREBINTHIFOLIUS ANTIOXIDANT ACTIVITY BY CAPTURE OF FREE
160 Artur Felipe Costa Amorim AMORIM. A. F. C 166
RADICAL 2.2-DIFENIL-1-PICRILIDRAZIL (DPPH)
161.1 Karla Monik Alves Da Silva SILVA. K. M. A. ANTIMICROBIAL ACTIVITY OF ANNONA CORIACEA L. AGAINST ORAL CAVITY BACTERIA 167
MINIMUM INHIBITORY CONCENTRATION OF ACANTHOSPERMUM HISPIDUM DC FRONT OF STREPTOCOCCUS
161.2 Karla Monik Alves Da Silva SILVA. K. M. A. 168
ORALIS BYTHE MICRODILUTION AND AGAR DIFFUSION METHODS
162.1 Laianne Carla Batista Alencar ALENCAR. L.C.B. ANTIMICROBIAL ACTIVITY OF ACANTHOSPERMUM HISPIDUM DC. BY MICRODILUTION 169
MICROBIOLOGICAL COMPARISON OF HYPTIS MUTABILIS BRIQ ACTION. BY THE MICRODILUTION AND AGAR
162.2 Laianne Carla Batista Alencar ALENCAR. L.C.B. 170
DIFFUSION METHODS
Fernando José De Lima DIAGNOSIS OF HYGIENIC-SANITARY CONDITIONS AND COMPLIANCE WITH GOOD MANUFACTURING
163.1 RAMOS JÚNIOR. F. J. L. 171
Ramos Júnior PRACTICES IN FOOD SERVICE AT PUBLIC DAY CARE CENTERS IN CAMPINA GRANDE-PB
Fernando José De Lima PREVALENCE OF INTESTINAL PARASITES AMONG STUDENTS OF PUBLIC DAY CARE CENTER IN THE CITY OF
163.2 RAMOS JÚNIOR. F. J. L. 172
Ramos Júnior CAMPINA GRANDE-PB
164 Jamilly Kelly Oliveira Neves APOLINÁRIO. A.C. FORMULATION AND EVALUATION OF SUNSCREEN EMULSIONS USING EXPERIMENTAL DESIGN 173
INTRINSIC DISSOLUTION: THE INFLUENCE OF THE TECHNIQUE ON THE KINETIC PARAMETERS EVALUATION OF
165.1 Maria Luiza Carneiro Moura MOURA. M.L.C 174
ANTIRETROVIRAL EFAVIRENZ
INTRINSIC VERSUS APPARENT DISSOLUTION: INFLUENCE OF COMPRESSION ON THE KINETIC EVALUATION OF
165.2 Maria Luiza Carneiro Moura MOURA. M.L.C 175
ANTIRETROVIRAL EFAVIRENZ
INVESTIGATION OF THE SPASMOLYTIC ACTION OF SOLANUM STRAMONIFOLIUM JACQ. ON RAT AORTA AND
167 Joedna Cavalcante Pereira PEREIRA. J.C. 176
GUINEA-PIG ILEUM
168 Vanessa Duarte De Almeida ALMEIDA. V. D. DE KINETIC STUDIES FOR ITRACONAZOLE USING OZAWA MODEL BY DYNAMIC THERMOGRAVIMETRY 177

15. Mariana Angélica Oliveira PHYTOCHEMICAL STUDY AND ANTI-INFLAMMATORY ACTIVITY OF AQUEUS EXTRACTS AND FRACIONS OF
169 BITENCOURT. MAO 178
Bitencourt MIMOSA TENUIFLORA (JUREMA PRETA) AND HANCORNIA SPECIOSA (MANGABEIRA)
Jahamunna Abrantes Andrade
170 BARBOSA. J. A. A. THERMAL ANALYSIS MULTCOMPONET COMPLEX WITH Β-CD AND METHOTREXATE 179
Barbosa
Dayanne Tomaz Casimiro Da
171 SILVA. D.T.C. PSEUDO-TERNARY PHASE DIAGRAMS AS A TOOL TO PRODUCE EMULSION E MICROEMULSION 180
Silva
Rayanne Sales De Araújo DETERMINATION OF MINIMUM INHIBITORY CONCENTRATION OF HYDROALCOHOLIC EXTRACT PLANT ON
172 BATISTA. R. S. A. 181
Batista CANDIDA SPECIES OF MEDICAL INTEREST
174 Adriano Francisco Alves ALVES. A. F THE CURINE ANTIINFLAMMATORY EFFECT IS A CYTOKINE DEPENDENT MECHANISM. 182
175.1 Rayllan Rodrigues RODRIGUES. R. O. DTA/TGA/DTG ANALYSIS OF EUTERPE OLERACEA (AÇAÍ) GLYCOLIC EXTRACT 183
175.2 Rayllan Rodrigues RODRIGUES. R. O. KINETICS STUDIES OF UVB SUNSCREENS: ETHYLHEXYL TRIAZONE AND ETHYLHEXYL METHOXYCINNAMATE 184
LECTIN ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY EXTRACTION. PURIFICATION AND EVALUATION
176 Ariane Priscilla M. Tenório TENÓRIO. A. P. M 185
OF CANNA LIMBATA ROSCOE SEEDS
RHEOLOGICAL ANALYSIS IN PRELIMINARY STABILITY STUDIES OF SUNSCREEN EMULSIONS CONTAINING AÇAI
177.1 Ipojucan Silva Fontes FONTES. I. S. 186
EXTRACT (EUTERPE OLERACEAE).
177.2 Ipojucan Silva Fontes FONTES. I. S. EVALUATION OF SUNSCREENS THERMAL ANALYSIS BY THERMOANALYTIC TECHNIQUES 187
NENHUM AUTOR STUDY OF ASSOCIATION BETWEEN OPG POLYMORPHISMS (- 163A>G; – 1181G>C) AND MRNA EXPRESSION IN
179 Melina Bezerra Loureiro SUBLINHADO
188
TYPE 1 DIABETES PATIENTS
THIRD ORDER EXPERIMENTAL APPROACH FOR HUMIDITY DETERMINATION IN THE LEAVES OF AZADIRACHTA
180 Denise Porfirio Emerenciano EMERENCIANO. D.P. 189
INDICA A. JUSS
HUMAN LEUCOCYTE ANTIGEN REGION AND DIABETIC NEPHROPATHY IN CHILDREN AND ADOLESCENTS WITH
181 Heglayne Pereira Vital Da Silva SILVA. H.P.V 190
TYPE I DIABETES OF RIO GRANDE DO NORTE. BRAZIL
Layany Carolyny Da Silva NENHUM AUTOR PREPARATION AND CHARACTERIZATION OF INCLUSION COMPLEXES FORMED OF ESSENTIAL OILS OF LIPPIA
182 191
Mourão SUBLINHADO SIDOIDES CHAM AND LIPPIA ORIGANOIDES HBK WITH Β-CYCLODEXTRIN
ASSOCIATION BETWEEN IGF-1 (-1245G>A). TGF-Β1 (-509C>T) AND LRP5 (126188 C>T) POLYMORPHISMS IN THE
183 Karla Simone Costa De Souza SOUZA. K.S.C 192
DEVELOPMENT TYPE 1 DIABETES
VALIDATION OF UV – SPECTROPHOTOMETRIC ANALYTICAL METHOD FOR THE DETERMINATION OF
Daiane Rafaela Meira Ribeiro
184 BATISTA. D.R.M.R PRAZIQUANTEL IN INCLUSION COMPLEXES WITH Β-CYCLODEXTRIN IN PRESENCE OF 193
Batista
HYDROXYPROPYLMETHYLCELLULOSE
EVALUATION OF COMPONENTS OF METABOLIC SYNDROME IN ADOLESCENTS WHO ARE OVERWEIGHT
185 Menilla Maria Alves De Melo MELO. M.M.A. 194
ACCORDING TO THE NATIONAL CHOLESTEROL EDUCATION PROGRAM - ADULT TREATMENT PANEL III
ENERGETIC ASPECTS OF CHEMICAL INTERACTION BETWEEN THE VIOMICYN ANTIBIOTIC AND BACTERIAL
186 Jéssica De Fátima Vianna VIANNA. J. F 195
RIBOSOME
VALIDATION OF A HPLC METHOD FOR THE QUANTIFICATION OF DIBUCAINE IN SOLUTION AND ENCAPSULATED
187 Raquel De Melo Barbosa BARBOSA. R. M 196
IN SOLID LIPID NANOPARTICLES OR NANOSTRUCTURED LIPID CARRIERS

16. 188.1 Itavielly Layany França Feitosa FEITOSA. I. L. F EVALUATION OF ANTIBACTERIAL POTENTIAL OF THE LEAVES OF SENNA OCCIDENTALIS (L.) LINK 197
EVALUATE OF THE ANTIFUNGAL ACTIVITY OF SENNA OCCIDENTALIS (L.) LINK.’S LEAVES FORWARD TO
188.2 Itavielly Layany França Feitosa FEITOSA. I. L. F 198
STRAINS OF CANDIDA SPP
189 Karla Samara Rocha Soares. SOARES. K.S. R CHITOSAN NANOPARTICLES FOR PROTEIN DELIVERY OBTAINED BY IONIC GELATION 199
Melissa Alexandra Da Rosa CLINICAL-EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH BREAST CANCER IN TO THE COMBINATION CANCER
190 COSTA. M.A.R 200
Costa CHEMOTHERAPY 5-FLUOROURACIL. EPIRUBICIN AND CYCLOPHOSPHAMIDE
ATIMICROBIAL ACTIVITY OF BIOACTIVE METABOLITES ISOLATED FROM STREPTOMYCES SPP. AGAINST
191.1 Geisa Nobre Oliveira OLIVEIRA. G. N. 201
PATOGENIC FUNGI YEAST
191.2 Geisa Nobre Oliveira OLIVEIRA. G. N. ACUTE TOXICITY OF CARVACROL 202
EVALUATION OF THE TOXICITY OF PRADOSIA HUBERI HYDROALCOHOLIC EXTRACT ON THE HYPOPHYSIS-
192 Liliane De Queirós Souza SOUZA. L.Q.S. 203
GONADAL AXIS OF PREGNANT FEMALE RATS
DRUG PROFILE OF ELDERLY DIABETES AND DYSLIPIDEMIA ATTENDED BY PHARMACEUTICAL CARE PROGRAM
193 Deysiane Oliveira Brandão BRANDÃO. D. O. 204
IN A COMMUNITY PHARMACY
194 Paulo Ricardo Silva Pereira PEREIRA. PRS EVALUATION OF HEMATOPOIESIS IN MALNOURISHED MOUSE MODEL 205
195 Raquel Araújo De Oliveira OLIVEIRA. R. A REPORTING OF DRUGS INDICATORS OF ADVERSE DRUG REACTIONS: STUDY IN A UNIVERSITY HOSPITAL 206
Gustavo Henrique De Medeiros
196 OLIVEIRA. G.H.M. STUDY OF TAQI/TGFΑ POLYMORPHISM IN NON-SYNDROMIC CLEFT LIP AND/OR PALATE 207
Oliveira
197 Maryanne Melo. MELO. M. N. PHYLLANTUS NIRURI L. REDUCE DAMAGE IN THE MUCOSAL IN MODEL OF COLITIS 208
198 Janaina Da Silva Goes GOES. J. S. COMPATIBILITY BETWEEN CAPTOPRIL AND EXCIPIENTS THROUGH THERMAL ANALYSIS 209
INTESTINAL PARASITES IN CHILDREN AND FOOD MANIPULATORS OF SCHOOL AND RESIDENTIAL OF A
199 José Izak Ribeiro De Araújo ARAÚJO. J.I. R 210
MUNICIPAL NURSERY IN JOÃO PESSOA- PB
CHARACTERIZATION OF SPRAY-DRIED PRODUCT AND LIOPHILIZED DRIED EXTRACT OF BAUHINIA FORFICATA
200.1 Evelyn Mirella Lopes Pina PINA. E. M. L 211
LINK BY INFRARED SPECTROSCOPY
EVALUATION OF INTERFERING LIPOPHILIC ON DETERMINATION OF CONTENT OF TOTAL FLAVONOIDS BY
200.2 Evelyn Mirella Lopes Pina PINA. E. M. L 212
SOLID PHASE EXTRACTION
PHYSICAL CARACTERIZATION OF SPRAY-DRIED PRODUCT AND LIOPHILIZED DRIED EXTRACT OF BAUHINIA
201.1 Monize Santos Peixoto PEIXOTO. M.S 213
FORFICATA LINK BY SCANNING ELECTRON MICROSCOPY (SEM) AND X-RAY DIFFRACTION.
EVALUATION OF HYGROSCOPIC IN SPRAY-DRIED PRODUCT (SDP) AND LYOPHILISATE DRIED EXTRACT (LDE)
201.2 Monize Santos Peixoto PEIXOTO. M.S 214
OF LEAVES OF BAUHINIA FORFICATA LINK
OMENA. RAFAEL SYNTHESIS. CHARACTERIZATION AND EVALUATION OF THE LEISHMANICIDAL ACTIVITY OF MEGLUMINE
202 Rafael Jorge Melo De Omena JORGE MELO
215
ANTIMONIATE IN PROMASTIGOTE FORMS OF LEISHMANIA MAJOR
INTERACTIONS OF ANTI-HYPERTENSIVE THERAPY DISPENSED BY THE MUNICIPAL HEALTH NETWORK OF
203 Nataly Miranda Do Nascimento NASCIMENTO. N. M. 216
MACEIO / AL

17. USE OF STATISTICAL PROCESS CONTROL AS A TOOL IN OPTIMIZING THE QUALITY OF THE PRODUCTION OF
204.1 João Paulo Tavares Malheiro MALHEIRO. J. P.T 217
DIPYRONE 500 MG/ML ORAL SOLUTION DROPS
ENVIRONMENTAL MONITORING IN THE FILLING LINE DROPS: AN ANALYSIS OF THE
204.2 João Paulo Tavares Malheiro MALHEIRO. J. P.T 218
ENVIRONMENT. PRODUCTIN PROCESS AND FINISHED PRODUCT DIPYRONE 500MG
205.1 Fabíola Lélis De Carvalho CARVALHO. F. L. PRELIMINARY EVALUATION OF THE ANTINOCICEPTIVE ACTIVITY OF THE SESQUITERPENE NEROLIDOL 219
205.2 Fabíola Lélis De Carvalho CARVALHO. F. L. SEROLOGICAL STUDY OF CHAGAS DISEASE IN THE CITY OF SALGADINHO/PB 220
EVALUATION OF PHYSICAL AND CHEMICAL COMPOSITION OF THREE CULTIVARS OF PAPAYA SEEDS
206 Alan Leite Moreira. MOREIRA. A.L. 221
PRODUCED IN THE NORTHEAST OF BRAZIL FOR POSSIBLE RECOVERY IN FOOD INDUST
207.1 Sarah Rafaelly Araújo Santos SANTOS. S.R.A. EXTRACTION AND CHARACTERIZATION OF CHITIN FROM SHRIMP WASTE OF RIO GRANDE DO NORTE - BRAZIL 222
207.2 Sarah Rafaelly Araújo Santos SANTOS. S.R.A. EVALUATION OF THE AUTHENTICITY OF A SAMPLE OF SENNA MARKETED IN NATAL-RN. 223
EVALUATION OF QUALITY OF SAMPLES OF BACCHARIS TRIMERA MARKETED IN DIFFERENT CAPITALS OF THE
208.1 Matheus Angêlos ANGELOS. M.A. 224
BRAZILIAN NORTHEAST THROUGH HPLC ANALYSIS
208.2 Matheus Angêlos ANGELOS. M.A. ANALYSIS OF EXTENDED RELEASE TABLETS BENZNIDAZOLE BY RAMAN SPECTROSCOPY AND MICROSCOPY 225
209.1 Fabiana Paiva Galvão GALVÃO. F. P DETERMINATION OF KINETIC PARAMETERS BY OZAWA FOR ALKALOID SYNTETIC WE010 226
209.2 Fabiana Paiva Galvão GALVÃO. F. P THERMAL CHARACTERIZATION OF ALKALOID SYNTETIC WE010 BY TG/DTA AND DSC 227
PARTICIPATION IN CLINICAL PAIN. FOLLOWING THE TREATMENT OF ANTIINFLAMMATORY NON-STEROIDAL
210 Monique Dielly JANUÁRIO. M.D.A. 228
ONCOLOGY WARD ASSISTANCE FOUDATION OF PARAIBA – FAP
Elton Max Nascimento Do
211 EGITO. E. M. N. THE QUEST FOR ION CHANNEL MEMORY USING A LIPID MEMBRANE 229
Egito
NENHUM AUTOR
213 Tamires Andrade Da Silva SUBLINHADO
PREPARATION OF DAPSONE-SILICATE NANOCOMPOSITES 230
INFLUENCE OF HIGH GLUCOSE CONCENTRATION ON BONE METABOLISM IN MICE C57BL/6 INDUCED WITH
214 Raul Hernandes Bortolin BORTOLIN. R.H. 231
HIGH-FAT DIET
215.1 Dayane Beserra Costa COSTA. D.B. CLINICAL AND EPIDEMIOLOGICAL ANALYSIS OF SCORPION STINGS IN CAMPINA GRANDE: PART II 232
215.2 Dayane Beserra Costa COSTA. D.B. SCORPIONIC AND OPHIDIAN ACCIDENT EPIDEMIOLOGIC PROFILE NOTIFIED IN CAMPINA GRANDE CITY 233
216 Mírian Letícia Carmo Bastos BASTOS. M. L. C HYPERTENSION: EDUCATIONAL ACTIVITY IN PUBLIC HEALTH 234
Leslie Raphael De Moura
218.1 FERRAZ. L.R.M. ANALYSIS OF DIFFERENT BATCHES OF BENZIDAZOLE BY HPLC AND FTIR 235
Ferraz
Leslie Raphael De Moura UTILIZAÇÃO DE TÉCNICAS ESPECTROMÉTRICAS PARA A CARACTERIZAÇÃO DO 3-(4-CLORO-BENZIL)-5-(4-
218.2 FERRAZ. L.R.M. 236
Ferraz NITRO-BENZILIDENO)-IMIDAZOLIDINA-2.4-DIONA (LFPS/FZ4)

18. IDENTIFICAÇÃO E SUSCETIBILIDADE ANTIMICROBIANA DE ENTEROCOCOS ISOLADOS NA CIDADE DO
220 Mizia Martins COSTA. M. K. C. M. 237
NATAL/RN. BRASIL
Daliana Maria Berenice De HUMAN LEUKOCYTE ANTIGEN-G AND -E EXPRESSION IN GASTRIC SPECIMENS IN PATIENTS WITH
222 SOUZA. DMBO 238
Oliveira Souza HELICOBACTER PYLORI
223 Joanda Paolla SILVA. J. P. R. COST-EFFECTIVENESS OF ANTIHYPERTENSIVE THERAPIES IN BASIC HEALTH SYSTEM 239
SURVEY OF RISK FACTORS FOR PREVALENCE OF CASES OF TYPE 2 DIABETES MELITTA IN THE CITY OF
224.1 Wende Soares FREITAS. W.S. 240
ARARA-PB
224.2 Wende Soares FREITAS. W.S. EPIDEMIOLOGICAL SURVEY IN CASES OF HEPATITIS TOWN OF CUITE - PB. BRAZIL. 2011. 241
USE OF BABASSU IN THE ADSORPTION OF CHEMICALS FOR WASTE TREATMENT IN INDUSTRY CHEMICAL AND
225 Gubbio Matos Da Silva SILVA. G. M. S 242
PHARMACEUTICAL
226 Lidyane Neves Miranda MIRANDA. L.N HUMAN LEUKOCYTE ANTIGEN-G AND TH17 EXPRESSION IN CERVICAL INTRAEPITHELIAL NEOPLASIA 243
Antônia Rosângela Soares
227.1 PENHA. A. R. S1 POSSIBLE ANTINOCICEPTIVE EFFECT OF LIPPIA MICROPHYLLA (VERBENACEAE) ESSENTIAL OIL IN MICE 244
Penha
Antônia Rosângela Soares INVESTIGATION OF ACUTE TOXICITY AND MIORRELAXANT EFFECT OF LIPPIA MICROPHYLLA (VERBENACEAE)
227.2 PENHA. A. R. S1 245
Penha ESSENTIAL OIL IN MICE
Cinthya Maria Pereira De CHARACTERIZATION OF THE OPUNTIA FICUS-INDICA (L.) MILL DRIED EXTRACT BY THERMAL ANALYSIS AND
228 SOUZA. C.M.P. 246
Souza INFRARED SPECTROSCOPY
NENHUM AUTOR EXPRESSION STUDY OF THE GENES INVOLVED ON FOLIC ACID METABOLISM IN ASSOCIATION WITH ORAL
229 Clélio Diogo Soares SUBLINHADO
247
CLEFT DEVOLOPMENT
230 Flávia Câmara De Souza SOUZA. F. C PARAMETERS KINETICS BY OZAWA MODEL FOR NICOTINAMIDE BY DYNAMIC TG 248
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATIVE METHOD OF ASCORBIC ACID (VIT C) FOR 500 MG
231 Arsênio Rodrigues Oliveira OLIVEIRA. A.R 249
TABLETS
DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTIFICATION OF SIMVASTATIN IN
232 Laura Da Fonseca Ferreira FERREIRA. L.F 250
MICROEMULSION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
RETROSPECTIVE AND CONCURRENT VALIDATION OF THE MANUFACTURING PROCESS OF ZIDOVUDINE 300MG
232.2 Arsênio Rodrigues Oliveira OLIVEIRA. A.R 251
+ LAMIVUDINE 150MG
A STUDY OF CYTOTOXICITY BY BIOASSAY TECHNIQUES OF THE HOMEOPATHIC PRODUCTS CONTAINING
233 Regina Carmen Espósito ESPÓSITO. R.C. 252
MOMORDICA CHARANTIA
234 Thaciane Da Cunha Soares SOARES. T.C UV-VIS ANALYSIS OF CHEMICAL MARKERS OF THE LEAVES OF PASSIFLORA EDULIS SIMS VARIETY EDULIS 253
Pedro Henrique Dos Santos ANTICONVULSIVANT AND ANXIOLITIC ACTION EVALUATION OF INDIGOFERA SUFFRUTICOSA MILLS AND
236 SOARES. P.H.S. 254
Soares INDIGO CARMINE IN MICE
DEVELOPMENT OF NEW METHODS OF ANALYSIS AND CONTROL OF
237 Lais Farias Azevedo AZEVEDO. L. F 255
METRONIDAZOLE TABLETS USING NEAR INFRARED
238.1 Marcelo Amorim AMORIM. M.V.P. CARACTERIZATION OF RIFAMPICIN AND THEIR DEGRADATION PRODUCTS BY CHEMICAL STRESS 256

19. 238.2 Marcelo Amorim AMORIM. M.V.P. COMPARISON STUDY OF TWO ANALYTICALS METHODS OF 4-FDC USING A SINGLE COLUMN 257
Leandro Vinicius Fernandes De EVALUATION OF ANALYTICAL METHODS APPLIED TO QUANTIFICATION OF LIPID PEROXIDATION IN LIVER
239 MORAIS. L. 258
Morais HOMOGENATE OF RATS
VALIDATION OF AN UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF PROPRANOLOL IN
240 Gabriela Diniz Fonseca FONSECA. G. D. 259
CAPSULES USING QUITOSAN AS EXCIPIENT
CHROMATOGRAPHIC PROFILE OF THE CRUDE EXTRACT AND FRACTIONS FROM K. BRASILIENSIS CAMBESS
241 Julia Morais Fernandes FERNANDES. J. M. 260
(SAIÃO) LEAVES
242.1 Cláudia Cecilio Daher DAHER. C. C. KINETCS STUDIES OF EUTERPE OLERACEA (AÇAÍ) EXTRACTS 261
242.2 Cláudia Cecilio Daher DAHER. C. C. SUNSCREENS O/W EMULSIONS STABILIZED BY RHEOLOGICAL MODIFIERS: PRELIMINARY STABILITY TESTS 262
STUDY BY QUANTUM MECHANICAL OF INTERACTIONS BETWEEN AMPA RECEPTORS AND FLUORINE
243 José Xavier De Lima Neto LIMA NETO. J. X. 263
WILLARDIINE
244 Vanessa Santos Temponi TEMPONI. VS EVALUATION OF THE ANTI-INFLAMMATORY POTENTIAL ETHANOLIC EXTRACT FROM VERNONIA POLYANTHES 264
245 Jucelia Barbosa Da Silva. SILVA. J.B EVALUATION OF THE ANTI-INFLAMMATORY POTENTIAL ETHANOLIC EXTRACT FROM VERNONIA CONDENSATA 265
EVALUATION OF MUTAGENICITY AND ACUTE TOXICITY IN MICE OF Spondias purpurea (Siriguela) ETHANOLIC
246 Vanda Lucia dos Santos SANTOS, V.L
EXTRACT.
266

20. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnose methods and pharmaceutical products
CODE 1
IMMUNOPHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF
HEMATOPOIETIC STEM CELLS AFTER MOBILIZATION IN MALNOURISHED
MICE
Pereira, P. R. S.1; Silva, B. C. O.1; Avelino, C. U. R.1; Cavalcanti Junior, G. B.2;
Borelli, P.3; Schimieguel, D. M.1
1
Laboratório de Hematologia Clínica; Departamento de Análises Clínicas e
Toxicológicas/CCS/UFRN.
2
Laboratório de Imunologia Clínica; Departamento de Análises Clínicas e
Toxicológicas/CCS/UFRN.
3
Faculdade de Ciências Farmacêuticas/ Departamento de Análises Clínicas e
Toxicológicas/USP.
Corresponding author: pauloricardo306@yahoo.com.br
Introduction: Hematopoietic stem cell transplantation (HSCT) is a therapy
performed in persons with hematologic malignancies. Recruitment of stem cells
from the bone marrow (BM) into peripheral blood (PB) is termed mobilization. Bone
marrow hypoplasia has generally treated intensively may decrease the
effectiveness of therapy, similar to that found in malnutrition. Objectives: To assess
the functional status and immunophenotypic profile of hematopoietic stem cells
after mobilization in a murine model of malnutrition and bone marrow hypoplasia.
Materials and Methods: We studied eight adult male BALB/c separated in two
groups: malnourished (D) and control (C). The group D (n = 5) received low-
protein diets for five weeks, and group C (n = 3) received normal protein diets ad
libitum. All animals were mobilized with G-CSF fo 5 d ys dose 100μg/Kg/d y.
On sixth day, animals were euthanized to obtain PB and BM, by washing the
medullary cavities of femurs and tibias. BM samples were cultured in
methylcellulose plus growth factors (IL-3, G-CSF, GM-CSF) for functional
evaluation by counting the colony-forming units (CFU); G-CFU and GM-CFU.
Quantification of HSC was performed by immunophenotyping (CD34+ and Sca-1+).
Results: There was no significant difference in quantification of HSC present in
BM/PB between the two groups. Total CFU and CFU-G were significantly
decreased in samples of group D than in group C (p = 0, 0357). Conclusion:
There was no difference in amount of cells mobilized from the BM niche of
malnourished group. However, functionally the HSC seem somehow damaged,
with reduced differentiation and proliferation.
Financial support from UFRN.
1

21. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnose methods and pharmaceutical products
CODE 2
IN VITRO ACARICIDAL AND CYTOTOXIC ACTIVITY OF AQUEOUS
EXTRACTS OF Agave sisalana PERRINE AND Furcraea selloa K.
KOCH
Macedo, A. L.1; Prata, M. C. A.2; Chedier, L. M.3; Sousa, O. V.4; Pimenta, D.
S.3; Pires, M. F. A.2.
1
Ph m ceu c sc ences m s e ’s s uden , UFJF.
2
Embrapa Dairy Cattle researchers.
3
Botanical Department, Biologic Sciences Institute, UFJF.
4
Pharmaceutic Department, Pharmacy College, UFJF.
Corresponding author: thumcd@gmail.com
Introduction: Agave sisalana Perrine e Furcraea selloa K. Koch, part of
Ag v ce e f m y nd popu y known s “p ”, h ve been used s
pesticides and antimicrobials agents in ethnoveterinary, especially as
acaridal. Objective: Evaluate the acaricial and cytotoxic activities of the
leaves infused of A. sisalana and F. selloa. Material and Methods: F.
selloa and A. sisalana leaves were collected in Juiz de Fora, Minas Gerais,
Brazil. The aqueous extract was obtained by infusion of the dried and
crushed leafs. Acaricidal activity was evaluated against Rhipicephalus
(Boophilus) microplus at extracts using the extracts in concentration ranging
of 40mg/mL to 200mg/mL. The citotoxic activity was tested against Artemia
salina exposed to extracts in concentrations ranging of 10 to 1000 g/mL.
Results and Discussion: Extracts don’ n e fe ed s gn f c n y n y ng
and hatching, but A. sisalana extract showed a light increase in the laying
and the F. selloa extract showed a light decrease of the same. The test
population showed resistance to pyrethroids, organophosphates and
m d nes s ng y nd n ssoc on. The ex c s we en’ ox cs g ns A.
salina in the tested concentrations, having F. selloa killed 22,5% and A.
sisalana 10,0% of the nauplii in the higher concentration. These results
corroborate with previous publication were the acaricidal activity were
associated with the cytotoxicity probably linked with the saponins presents
in these species. Conclusion: The obtained results indicate that the leaves
nfused of bo h spec es don’ h ve c c d nd c o ox c c v es. Nex
studies should focus on the leaves methanolic extracts of F. selloa.
Financial support from FAPEMIG and master scholarship from
Embrapa dairy cattle.
2

22. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnose methods and pharmaceutical products
CODE 3
PRELIMARY STUDY OF BORNEOL SALICILATE ANTIINFLAMATORY
ACTIVITY
Vasconcelos, R. M. C.¹; Leite, J. A.; Leite, F. C.¹; Rodrigues, L. C.²;
Piuvezam, M. R.¹
¹Laboratório de Imunofarmacologia, Centro de Biotecnologia, Universidade
Federal da Paraíba (UFPB).
²Laboratório de Farmacoquímica, Centro de Biotecnologia, Universidade
Federal da Paraíba (UFPB).
Corresponding author: renatacostav@gmail.com
Introduction: Borneol Salicilate (BoS) is a synthetic compound obtained
by esterification reaction of salicylic acid and (-)-borneol alcohol. The
diastereomer (-)-borneol has been described as a potential anti-
inflammatory molecule in neuronal cells. Objective: The goal of this study
was to evaluate BoS in murine models of inflammation. Material and
Methods: The experimental models used were carragenaan-induced paw
edema and zymosan-induced peritonitis. Swiss mice (n=6) orally
pretreated with 50, 100 or 200 mg/kg BoS or 200 mg/kg acetylsalicylic acid
(AAS) as control drug rece ved n njec on of 20 μL of c gen n
(2,5%) in left paw and NaCl 0,9% solution in right paw. The paw volume
was measured in different times to evaluate the edema formation. In the
peritonitis experimental model, pretreated animals (n=8) received an
n pe one njec on of 500 μL of zymos n (2 mg/mL) nd 4 hou s f e
the peritoneum was exposed and the fluid was collected with 1 mL ice-cold
PBS. The aspirate was centrifuged and the cells were ressuspended and
counted in hemocitometer. Results and Discussion: The pretreatment
with BoS (200 mg/kg) was significantly (p<0.05) effective in inhibiting the
paw edema in 1h, 2h, 6h and 24h, as well as the AAS; however, the minor
doses of BoS were not effective. The BoS (200 mg/kg) also reduced
significantly (p<0.05) the neutrophil migration to peritoneum. Conclusion:
These preliminary data suggest that BoS has anti-inflammatory effects
related with eicosanoid mediators.
Financial support from CNPq/Brazil and master scholarship from
CAPES/Brazil
3

23. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnose methods and pharmaceutical products
CODE 4
ESTIMATION OF CARDIOVASCULAR RISK BY THE FRAMINGHAM
SCORE IN HYPERTENSIVE PATIENTS
Portela, A. S.1,2; Silva, P. C. D.2; Falcão, R. A.2; Malheiro, J. P. T.2;
Montenegro Neto, A. N.2; Almeida, M. G.1,3; Simões, M. O. 2
1
Programa de Desenvolvimento e Inovação Tecnológica de
Medicamentos, Universidade Federal do Rio Grande do Norte (UFRN).
2
Laboratório de Pesquisa em Bioquímica Clínica, Departamento de
Farmácia, Universidade Estadual da Paraíba (UEPB).
3
Laboratório Multidisciplinar, Departamento de Análises Clínicas e
Toxicológicas, UFRN.
Corresponding author: moscg@uol.com.br
Introduction: Cardiovascular diseases are the leading cause of death in
Brazil. The main risk factors for these diseases are Arterial
Systemic Hypertension, dyslipidemia, smoking and Diabetes
Mellitus (DM). Material and Methods: Based on this framework, this
study aims to evaluate the cardiovascular risk of hypertensive
patients by the Framingham risk score. It is a cross-sectional study which
included a random sample of 53 individuals with hypertension treated at
the Municipal Health Service of Campina Grande, in Paraíba. It was
adopted the Framingham score, taking into account the sum
of points obtained from the set of risks, from the age, presence of
diabetes, the practice of smoking, blood pressure and the ratio
between total cholesterol and HDL. Results and Discussion: From the
results, it was observed that 81.25% of the male population had risk equal
or more than 10% for cardiovascular complications estimated at 10
years, according to Framingham scores. In women, on the contrary,
statistical analysis showed that this risk was 76.47% less than or equal to
8%. Conclusion: The results showed the importance of implementing
the score in Primary Care, which allow for early diagnosis of people at risk
and identify remedial measures that may be effective in treating
and preventing cardiovascular events, many of them fatal, avoiding
personal suffering and reducing costs to the health system and society.
Financial support: Incentive Program for Graduate Studies and
Research (PROPESQ) UEPB
4

24. II INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL SCIENCES:
Challenge and opportunities for development new diagnose methods and pharmaceutical products
CODE 5
CHARACTERIZATION OF A CATIONIC NANOEMULSION INTENDED
TO GENE THERAPY AFTER STERILIZATION PROCESSES
Silva, A. L.¹,²; Alexandrino-Junior, F.¹,²; Silva, K. S.¹; Veríssimo, L. M.¹,²;
Lima, L. F. A.²; Egito, E. S. T.¹
¹Laboratório de Sistemas Dispersos (LaSiD), Departamento de Farmácia
(UFRN);
²Laboratório de Biologia Molecular e Genética (LBMG), Centro de
Biociências (UFRN).
Corresponding author: socrates@ufrnet.br
Introduction: Gene therapy is based on the transfer of genetic material
into the target defective tissue or cell. For its success, it is necessary to
develop carriers able to bypass both, membrane and citosol barriers,
reaching the nucleus. Most of the researchers deals with viral approaches.
However, concerns about safety have increased studies on non viral gene
delivery systems like nanoemulsions. Objective: The aim of this work was
to evaluate autoclaving and filtration as methods to guarantee a cationic
nanoemulsion system sterility, which makes in vitro assays possible.
Material and Methods: The nanoemulsion, prepared by sonication
method, was made of Captex 355®, Span 80®, Tween 80®, water and
stearylamine. Sterilization processes was done as follow: filtration by 0.22
µm filter and autoclaving for 15 min at 1 atm and 121°C. Then,
characterization by macroscopic analyses, zeta potential and size
measurements were performed. Results and Discussion: The results
showed that, as expected, phase separation happens when autoclaving
was used to sterilize the nanoemulsion (a thermodynamically unstable
system). Concerning the filtration method, the characteristics of the system
were maintained. The unsterilized nanoemulsion presented size of 240 nm
and zeta potential value of +26.6 mV. After filtration, the system presented
233 nm of size and +23.9 mV of Zeta Potential. Polidispersivity Index
decreased from 0.201 to 0.176 after filtration, meaning that size distribution
was more homogenous after the filtration process. Conclusion: These
results demonstrate that sterile filtration is a suitable process to sterilize
cationic nanoemulsion for gene therapy making possible the future use of
cationic nanoemulsions for gene delivery.
5