2. Rheumatoid Arthirits (RA) is a complex disease
that affects approximately 0.5% of the adult
population worldwide, and occurs in 20-50 cases
per 100,000 annually, mainly in women after their
40s (Carmona et al. 2010).
www.webmd.com
3. Affects different articulations in the body.
It is an auto-immune disease.
There is no clear cause for this disease.
noeydali.blogspot.es
4. Genetic and Environmental triggers are implicated
in the pathogenesis of this disease.
RA consists of at least 2 different subsets
characterized by the presence or absence of
antibodies to citrullinated protein antigen (ACPA)
(Svendsen et al. 2013).
6. Genes with the major histo-compatability complex
appear to have the strongest influence on disease
susceptibility.
www.rcsb.org
7. General lifestyle factors like: smoking, because it
shows a clear interaction with genetic
susceptibility genes.
Pregnant women whose pregnancies were
complicated by hyperemesis, gestational
hypertension or preeclampsia. Have an increased
risk of RA.
www.babiesandtoddlers.com
8. The main goals are:
take away pain
reduce swelling
slow down or stop joint damage
make people feel better and stay active.
9. Methrotrexate (MTX) is considered the anchor
drug for the treatment of RA; it is administered in
up to 70% of patients with this disease (Cipriani et
al. 2014).
mc.usp.org
14. Regular exercise
Rest and Relaxation
Tai Chi (slow, gentle movements and deep
breathing)
The use of heat and cold
http://www.healthline.com/
15. The severity of RA has declined over the past few
decades.
By knowing possible risk factors, we can make
more effective treatments to slower down this
process.
Research is being done now on: immune systems,
genes and drug combinations.
16. Cipriani P, Ruscitti P, Carrubi F , Liakouli V, Giacomelli R. 2014.
Methotrexate in Rheumatoid Arthritis: Optimizing Therapy Among
Different Formulations. Current and Emerging Paradigms. Clinical
Therapeutics [Internet]; [cited 2014 Sep 25]. 36(3):427-
435.doi:10.1016/j.clinthera.2014.01.014
Gaujoux-Vialaa C, Gossecb L, Cantagrelc A, Dougadosd M, Fautrelb
B, Mariettee X, Nataff H, Sarauxg A, Tropei S, Combej B. 2014.
Recommendations of the French Society for Rheumatology for
managing rheumatoid arthritis. Joint Bone Spine [Internet]; [cited
2014 Oct 3]. 81(4)287-297.doi: 10.1016/j.jbspin.2014.05.002
Svendsen A, Kyvik K, Houen G, Junker P, Christensen K,
Christiansen L, Nielsen C, Skytthe A, Hjelmborg J. 2013. On the
Origin of Rheumatoid Arthitis: The Impact of Environment and
Genes-A Population Based Twin Study. PLoS One [Internet]; [cited
2014 Oct 31]. 8(2). doi:10.1371/journal.pone.0057304