2. Group D Strep Bacteremia
• Catalase-negative, gram positive cocci, express Lancefield Group D antigen
3. Association with disease
• S. bovis biotype 1 (S. gallolyticus gallolyticus)
• Endocarditis and colonic neoplasm
• S. bovis biotype 2.1
• Biliary tract disease
• S. bovis biotype 2.2
• Infections in neonates and infants
4. S. gallolyticus gallolyticus
• GI tract is most likely source for entry
• Accounts for ~6% of IE cases (10% in Europe to 2% in N. America)
• Typically older, less likely than other Pts with IE to have risk factors for IE such as IV drug use or structural
heart disease.
• Tend to have sub-acute presentation, large vegetations, and more likely to involve >1 valve
• Some studies have shown IE in 43-100% of pts infected with S. gallolyticus (only 8-29% seen in S. bovis
biotype II)
• Controversial relationship between GDS fecal carriage and colorectal cancer.
• GDS has been isolated in the stool of 2-12% healthy people and up to 50 % of individuals with colorectal tumors
• Current theory is that the organism likely exerts its effect during the later stages of colorectal cancer rather than as an inducer
of mutations in the early phases of tumorigenesis
