Dear sirs, My name is Edgard Lion and I am a general surgeon who have being working for the pharma industry for some years now. After finishing my studies at the Medicine college of the University of Sao Paulo (USP) and residency in general surgery at the clinics hospital (USP) I went through a MBA program in marketing at ESPM school and Wharton School of the university of Pennsylvannia besides getting a ICH-GCP certification in clinical research. I lived in the United Sates so I speak fluent english. I the last years I have worked as a Medical Manager in different positions and therapeutic areas for multinational companies as Schering-Plough (rheumatology, orthopedics, dermatology), Pfizer (central nervous system), Searle-Monsanto (rheumatology and orthopedics). At the largets Brazilian pharma company (laboratorio Ache) I had the opportunity to manage people (regulatory affairs manager, clinical research manager, pharmacovigilance manager plus five medical managers) for three years besides giving technical/scientific support to new business department focusing new strategic registry (NDAs), clinical research and scientific support for OTC and phytomedications. At Novartis I worked for more than eight years ans a senior Medical Manager for ophthalmology and mature products including sales force training, KOLs training, promotional aids review, advisory boards meetings, regulatory affairs technical support, scietific relationship with key opinion leaders and key decision makers. I also had the oportunity to work for a life and health insurance company looking over five medical manager at headquarters and 25 medical staff audits all over Brazil. I also contributed as a MSL for Sanofi's oncology being responsible for chemotherapy for CRPC (taxanes) and immunebiologics for metastatic colon cancer (anti-VEGF therapy). With these credentias I present my self for your assessment. Regards, Edgard da Veiga Lion Neto, MD, MBA edgard.lion@uol.com.br Cell: 55+11+993429036 Home55+11+55336201

1. Edgard da Veiga Lion Neto, MD; MBA
Clinical Research Clinical Research Clinical Research Clinical Research
Rua Açatunga, 149
Campo Belo, São Paulo – SP - 04612-050
Tel (011) 5533-6201 / Cel.: (011) 99342-9036
edgard.lion@uol.com.br
Professional Profile
Clinical research Clinical research Clinical research Clinical research Clinical research
• Medicine College of the University of São Paulo (FMUSP).
• Medical Residency in Surgery at the Clinics Hospital of the FMUSP.
• M. B. A. in Marketing and Communication at ESPM
• Legal Medicine and Expert Testimony specialist at University of São Paulo
• Experience in development and managing of IITs, clinical trials phase III and IV with GCP standards.
• Years of experinece with Health Authorities (ANVISA, Min. da Saúde) focusing new product registration and
demands solving.
• Years of knowledge in support and managing of ethical marketing for mass and specialty products.
• Active participation in multitask multifunctional international work groups with Global Medical Marketing teams.
• Years of practice in the development and managing of product Advisory Boards, support to continuous medical
education, and support to patient associations.
• Experience in sales force, medical doctors and scientific medical liasons training towards products detailing.
• Experience in co-managing MSLs.
• Fluent english
Languages
• English: fluent
• Spanish: basic
• French: basic
PROFISSIONAL HISTORY
Clinical Research, clinical research, clinical research
Sanofi – MSL Oncology – May 2013
Position : Medical Science Liaison
Report: Group Medical Manager
Main contributions:
• Technical detailing of clinical trials and clinical characteristics of therapeutic agents (chemotherapy and immune
biologic drugs) designed for solid tumors (Prostate and Colon).
• Scientific relationship with top KOLs, KDM and ROLs in hospitals and clinics.
• Training of technical sales consultants.
• Scientific relationship with medical societies.

2. • Developing of clinical trials and IST/IIT trials with KOLs.
• Scientific discussion of key messages with KOLs, KDMs and ROLs on chemotherapy and immune biologic drugs
for Prostate and Colon cancer.
• Extensive participation on international meeting and congresses.
Boehringer-Ingelheim – Senior Medical Manager- Neurology (Parkinson), Urology (BPH) e
Antibiotics – March 2013
Position : Senior Medical Manager
Report : Chief Scientific Oficer
Main contributions:
• Technical support to Marketing on all promotional activities with drugs for Parkinson Disease, Prostate Benign
Hyperplasia and antibiotics.
• Technical support for regulatory affairs concerning new produts registration and HA demands solving.
• Training of the sales force in all technical and clinical details of the drugs under my responsability and their direct
competition.
• Coordination of technical translations.
• Technical and scientific support for marketing strategies implementation.
• Revision of package inserts ans scientific support for DRA and Customer Services department.
• Technical and scientific support for all promotional activities of the products under my responsability.
Novartis – Senior Medical Manager for Ophthalmology – Jan 2004 / Jul 2012
Position : Senior Medical Manager
Report : Chief Scientific Officer
Main contributions:
Strategic support to the Specialty Business Unit (Ophthalmology) and Mature Products:
• Development and implementation of clinical research projects (compassionate use, IIT and phase III /
IV) with immune biological products.
• Execution of the medical publication plan through educational support to independente studies (IITs) in
line with global strategies.
• Technical/scientific support for revision and approval of promotional aids and strategic revision of
medical literature searching for product competitive advantages in product promotion.
• Technical/scientific support to continuing medical education, workshops, satellite symposia and other
medical events.
• Revision and approval of promotional material, strategic revision of medical literature in order to localize
technical details to differentiate the company products.
• Technical support for implementation of marketing strategies with immune biologic and mature products.
• Medical Advisor for LatAm mature products (three years in the position).
• Technical support and scientific identification of new business (BD&L) looking for joint ventures in
product development and partnetships.Direct involvement in scientific counsulting corporate affairs with
opinion leaders and patient associations.
• Training and development of sales force and scientific counsulting force (MSLs) towards product
detailing and competitors.
• Co-managing of MSLs.
• Training of opinion leaders.
• Scientific Strategic and operational support for DRA and Market Access.
• Active participation on national and international events.
• Medical manager for Antiinflamatory/analgesic, Central Nervous System, Cardiology, Dermatology,
Ophthalmology and Mature Products
• MSL for Cardiology, Rheumatology and Orthopedy.
Aché Laboratórios – Abr 2001 / Out 2003
Clinical research, clinical research, Clinical research, Clinical Research
Position : Medical Director
Report : Executive director of Marketing and sales

3. Main contributions:
• Supervision of five Medical Managers, one Regulatory Manager and one Pharmacovigilance Manager
• Creation of the pharmacovigilance department.
• Scientific support for marketing strategy implementation.
• Strategic development of clinical research projects, identifications of investigators and research centers.
• Strategic and operational support for DRA and Market Access.
• Support for marketing and corporate public relations strategies.
• Technical support and scientific identification of new business (BD&L) looking for joint ventures in product
development and partnerships together with McKinsey Management Consulting Firm (over 1,000 new
molecules and SKUs overseen).
• Technical/scientific support for licening in of new molecules and development of combination of molecules as
new products including synthetic and phytomedications.
• Active participation with HA discussions and negotiations.
• Active participation on national scientific events.
Searle Monsanto – Jan 1999 / Dez 2000
Clinical research, clinical research, Clinical research, Clinical Research
Position : Medical Manager/Training Medical Manager LatAm (COXIB)/Scientific Consulting
Report : Chief Clinical Scientific Officer LatAm/Asia-Pacific
Main contributions :
• Direct participation on scientific consulting, public relations, and training of opinion leaders.
• Technical support for the lauching of the first COXIB in the market (Celecoxib).
• Training Medical leader for the COXIB products in LaTam.
• Technical support for the marketing area in promotional activities.
• Sales force training and development.
• Clinical research development, protocol writing, CRFs and diaries writing.
• Identification of investigators and clinical research centers.
• Implementation and conduction of phase IV clinical trials.
• Strategic and operational support for DRA.
• Training and development of opinion leaders.
• Active participation on national and international scientific events.
Pfizer – Abr 1997 / Dez 1998
Clinical research, clinical research, Clinical research, Clinical Research
Position : Medical Manager
Report : Clinical Scientific Officer
Main contributions :
• Scientific and operational support for marketing promotional activities.
• Development and implementation of Central Nervous System clinical research projects (phase III / IV).
• Training and development of sales force.
• Coordination of clinical research associates.
• Coordination of scientific translations.
• Protocol, CRFs and diaries development.
• Identification of investigators and clinical research centers.
Schering - Plough – Abr 1996 / Abr 1997
Clinical research, clinical research, Clinical research, Clinical Research
Position : Medical Manager
Report : Chief Scientific Officer
Main contributions :
• Scientific and operational support for marketing promotional activities.
• Training and development of sales force.
• Strategic and operational support for DRA.
• Protocol, CRFs and diaries development.
• Technical support and scientific identification of new business (BD&L) looking for joint ventures in product
development and partnetships.
• Development and implementation of clinical research projects (phase III / IV).
• Identification of investigators and clinical research centers.

4. • Active participation on national scientific events.
Sul América Aetna Insurance – Jan 1995 / Dez 1996
Position : Medical Supervisor
Report : Medical Superintendent
Main contributions :
• Teams supervision:
− Five local medical analysts for assessment of personal and company health providers.
− Twenty five medical audits at national level.
− Technical support to reinbursement and debt department.
• Technical support to the vice presidency and legal department.
• Active participation on new product development.
• Training of medical analysts.
GRADUATION
• Eletrotechnics at Federal School of São Paulo - 1981
• Medicine college of the University of são Paulo - 1988
• Medical Residency in Surgery at the Clinics Hospital - 1992
• Medical proficiency by the Educational Commission of Foreign Medical Graduates (FMGEMS), USA (1992)
• Specialization on Hospital administration (CEDAS) – São Camilo - 1994
• Specialization on Marketing admnistration (FEA-USP) – 1995
• 100 IMS pharmaceutic marketing - 1996
• Field Monitoring and Medical Orientation Seminar at Pfizer, Inc, New York.; Product Management Development
at Pfizer (RJ) – 1997
• Industrial Marketing at Wharton School of the University of Pennsylvania, USA.;
• Social Styles at Monsanto in Toronto, Canadá – 1999.
• Statistical methods in clinical research (SBPPC) – 2001.
• Bioestatistics UNIFESP – 2002
• Certification on ICH-GCP Clinical Research by the Novartis International Clinical Research Organization - 2006
• M.B.A in Marketing and Communication - ESPM – 2006
• Legal Medicine and Expert Testimony specialization – University of Sao Paulo - 2013
CLINICAL EXPERIENCE
• Private office – 1990 - 1995
• HMO medical surgeon - Grupo Eluma – 1992 - 1995
• Emergency medicine - SAMEB – 1994 - 1997
SOCIETIES
• Member of the Sociedade Brasileira de Medicina Farmacêutica (SBMF)
• Coordinator of the IT committee - SBMF
• First Secretary - SBMF (2006-2007)
TITLES
• Proficiency in Medicine by the Educational Commission of Foreign Medical Graduates (FMGEMS), USA (1992)
• International Clinical Research / ICH-GCP Compliance by Novartis International Clinical Research Organization
(ICRO)

5. PUBLICATIONS
Avaliaçäo do DNA pela citofotometria nos tumores papiliferos da tireoide / DNA evaluation by cytophotometry in papillary
thyroid tumour
Rev. Col. Bras. Cir; 17(5):90-3, set-out. 1990.
RECOMENDATIONS
• Ricardo Maykot, MBA (Marketing and sales executive Director Novartis): Edgard has a robust background in
several therapeutic areas, a good sense of medical-marketing strategies which enable him for various
positions in the pharma industry. Extremely reliable, good player working in teams, he conquered my respect
and trust."
• Leandro Mattos Boer Martins, MD, PhD (Medical Specialist Novartis USA): "Edgar is an experienced,
proactive and tireless contributor who makes great addition to any medical team. He always completes his
assignments on time with excellence and is committed to the team in times of very difficult challenges and
corporative overturns. I would highly recommend him for any medical position in the pharmaceutical
industry."
• Felipe Pinho, MD, PhD (Diretor Médico Instituto do Sono - UNIFESP): "I worked with Edgard in Schering-
Plough. He has the two most important skills to work in a pharmaceutical company: high level technical
knowledge and impeccable ethical values."
• - Alvaro Cavalcante (Gerente de Produtos Novartis): "Edgard é um profissional multifuncional, com sólida
experiência em diversas áreas terapêuticas. Tem perfil "hands on" e rapidamente se adapta a estrutura de
negócio."
• Leonardo Mallmann (Senior Marketing Manager for HIV - Virology at Merck): "Dr. Edgard is a detail-oriented
medical manager who doesn´t lose sight of the strategic objective and is focused on growing the business.
• Julio Madi (Sr. Medical Adviser at Hypermarcas S/A): “Edgard is a well-known medical manager at the
pharma industry. He is an "easy to work with" person who can challenge you in a positive and result-oriented
way. Always looking ahead, he is nice as a medical-marketing team player in different therapeutic areas.”
• David Lago (Legal Director Safra Bank, former Senior Legal Manager Novartis): "Edgard is an outstanding
professional, highly competent and committed, with wide experience as Medical Manager. He has very good
relationship with his colleagues and focus on the company’s targets."
• Renata Berardocco, PharmD (Project Director & Head of Brazil at Covance): "Edgard is a very good
professional and results oriented. He is a pleasant person to work with and a good team player."
REFERENCES
• Silvia Sfeir (Director of Market Access, Public Commercial Sales, Health Economics, BD&L and New
Products Planning Novartis): Silvia.sfeir@novartis.com Phone +55 11 55327122 Cell: 99656-1036.
• Patricia Pigola, PharmD (Director of Regulatory Affairs da Novartis): patricia.pigola@novartis.com Phone +
55 11 55327590
• João Navarro, MD, MBA (Sanofi LatAm Medical Manager), joao.navarro@sanofi.com.br, phone: 55 11
37596726

6. • Felipe Dos Santos Pinho, MD, PhD (Instituto do Sono - UNIFESP ): f.spinho@uol.com.br ou
felipe.pinho@ems.com.br Phone 55 19 92127964
• Ricardo Maykot (Executive Director, Commercial Operations, Inovation and BU support, Novartis):
ricardo.maykot@novartis.com Phone +55 11 5532-7713
• Leandro Martins, MD, PhD (Medical Specialist Novartis New Jersey, NJ, USA):
leandro.martins@novartis.com Phone +1 862 7783959

7. • Felipe Dos Santos Pinho, MD, PhD (Instituto do Sono - UNIFESP ): f.spinho@uol.com.br ou
felipe.pinho@ems.com.br Phone 55 19 92127964
• Ricardo Maykot (Executive Director, Commercial Operations, Inovation and BU support, Novartis):
ricardo.maykot@novartis.com Phone +55 11 5532-7713
• Leandro Martins, MD, PhD (Medical Specialist Novartis New Jersey, NJ, USA):
leandro.martins@novartis.com Phone +1 862 7783959