The document discusses the diagnosis of female genital tuberculosis (GTB). GTB is a common cause of infertility in developing countries. Diagnosis can be challenging as clinical symptoms often develop years after infection and many diagnostic tests lack sensitivity and specificity. Newer diagnostic approaches for GTB including molecular tests such as PCR, QFT-G, and nucleic acid amplification have improved detection rates compared to traditional tests like microscopy, culture and histopathology. A combination of diagnostic methods provides the best approach for accurately diagnosing GTB.

1. Diagnosis of Female Genital TB Anuj Sharma

19. QFTG Test not interpretable Indeterminate M. tuberculosis infection unlikely, but cannot be excluded in immunocompromised patients, or highly probable cases Negative (No ESAT-6 or CFP-10 responsiveness detected) M. tuberculosis infection likely Positive (ESAT-6 and/or CFP-10 responsiveness detected) Interpretation Result

23. BacT/ALERT 3D The first BacT/ALERT 3D 960 in India

28. SGRH Experience 21 10.45 AFB S/T 22 11.95 Mean detection time (days) LJ medium BacT/Alert 3D

32. MTD Test Performance Smear-Positive Patients 37 87.5% 100% 100% 96.7% 7H10/7H11 39 63.6% 100% 100% 87.5% LJ 39 87.5% 100% 100% 96.9% BACTEC 39 87.5% 100% 100% 96.9% MTD Number of Patients NPV PPV Specificity Sensitivity

33. MTD Test Performance Smear-Negative Patients Number of Patients NPV PPV Specificity Sensitivity 167 93.4% 100% 100% 60% 7H10/7H11 160 95.1% 100% 100% 72% LJ 167 94.7% 100% 100% 68% BACTEC 167 95.3% 94.7% 99.3% 72% MTD

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