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Blood – The essence of
                       Life


          STOP                     STOP
   BLOOD LOSS                    BLOOD LOSS
                  LIFE GOES ON



Basem Wadea
Haemostop®

   INTRODUCTION
   haemostasis is achieved by several mechanisms
   including mainly:


    􀂉 Vascular contraction

    􀂉 Formation of a platelet plug

    􀂉 Formation of a blood clot as a result of blood
   coagulation.

    􀂉 Eventual growth of fibrous tissue into the blood clot
   to close the hole in the vessel properly.

Basem Wadea
Haemostop®

  1) Vasoconstriction
 2) Platelet plug formation




    3) Blood clotting


Basem Wadea
Haemostop®
       Haemostop® Acts on the 1st step of hemostasis

      Hetero adhesiveness




                                          Homo adhesiveness




Basem Wadea
Haemostop®


    Haemostop® (Ethamsylate) is a prostacycline
    synthetase inhibitor. As prostacycline is a
    vasodialator, Ethamsylate does this to help
    effective RESTORING CAPILLARY
    RESISTANCE.

    Haemostop® (Ethamsylate) reduces rapidly
    and substantially the bleeding time (40-45% after
    the first half-hour). Its effect remains at a
    therapeutic level until the sixth hour (23%) then
    declines progressively.

Basem Wadea
Haemostop®
   Haemostop® (Ethamsylate) augments the
   formation of platelet plug by increasing the
   aggregation and adhesiveness of platelet and
   restores Capillary Resistance (Angioprotective)

   Haemostop® not causes vasoconstriction, or
   anti-fibrinolytic actions and does not modify the
   plasma clotting factors (fibrinogen level and
   coagulation time remain unchanged).
   .



Basem Wadea
Haemostop®
    Haemostop® in:
    Pregnancy: Studies in animals have
    revealed no teratogenic effect of
    Ethamsylate. Use only if clearly
    needed.
    Lactation: Signification amount is
    excreted in milk but not known to be
    harmful.


Basem
Haemostop®

   Dosage & Administration: Curative treatment: According
   to the severity of the case:

   - 2 ampoules I.V. or I.M., then 1 ampoule or 2 tablets
   Haemostop® 250mg or one tablet Haemostop® 500mg
   every 4 to 6 hours until there is no further risk of
   bleeding.

   - By local application: A tampon of cotton-wool is
   soaked with the content of one ampoule and applied to
   the bleeding area or placed in the tooth socket after a
   dental extraction. The application may be repeated if
   necessary and may also be associated with oral or
   parenteral administration.

Basem Wadea
Haemostop®

   Dosage & Administration: Curative treatment:
   According to the severity of the case:

   - Before operation: 2 ampoules I.V. or I.M. 1
   hour before operation or 2 or 3 tablets
   Haemostop® 250mg 3 hours before operation.
   - During operation: 2 ampoules I.V. to be
   repeated if necessary.
   - After operation: 1 ampoule or 2 tablets
   Haemostop® 250mg or one tablet Haemostop®
   500mg every 6 hours as long as the risk of
   bleeding persists.

Basem Wadea
Haemostop®
   How supplied:
   Ampoules:
   Ampoules of 2ml in packs of 3 Ampoules.

   Tablets :
    Strips of 10 Tablets Haemostop® 250mg in packs of 1
   or 2 strips.
    Strips of 5 Tablets Haemostop® 500mg in packs of 2
   strips.




Basem
Haemostop®




Basem Wadea

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Stop Blood Loss with Haemostop

  • 1. Blood – The essence of Life STOP STOP BLOOD LOSS BLOOD LOSS LIFE GOES ON Basem Wadea
  • 2. Haemostop® INTRODUCTION haemostasis is achieved by several mechanisms including mainly: 􀂉 Vascular contraction 􀂉 Formation of a platelet plug 􀂉 Formation of a blood clot as a result of blood coagulation. 􀂉 Eventual growth of fibrous tissue into the blood clot to close the hole in the vessel properly. Basem Wadea
  • 3. Haemostop® 1) Vasoconstriction 2) Platelet plug formation 3) Blood clotting Basem Wadea
  • 4. Haemostop® Haemostop® Acts on the 1st step of hemostasis Hetero adhesiveness Homo adhesiveness Basem Wadea
  • 5. Haemostop® Haemostop® (Ethamsylate) is a prostacycline synthetase inhibitor. As prostacycline is a vasodialator, Ethamsylate does this to help effective RESTORING CAPILLARY RESISTANCE. Haemostop® (Ethamsylate) reduces rapidly and substantially the bleeding time (40-45% after the first half-hour). Its effect remains at a therapeutic level until the sixth hour (23%) then declines progressively. Basem Wadea
  • 6. Haemostop® Haemostop® (Ethamsylate) augments the formation of platelet plug by increasing the aggregation and adhesiveness of platelet and restores Capillary Resistance (Angioprotective) Haemostop® not causes vasoconstriction, or anti-fibrinolytic actions and does not modify the plasma clotting factors (fibrinogen level and coagulation time remain unchanged). . Basem Wadea
  • 7. Haemostop® Haemostop® in: Pregnancy: Studies in animals have revealed no teratogenic effect of Ethamsylate. Use only if clearly needed. Lactation: Signification amount is excreted in milk but not known to be harmful. Basem
  • 8. Haemostop® Dosage & Administration: Curative treatment: According to the severity of the case: - 2 ampoules I.V. or I.M., then 1 ampoule or 2 tablets Haemostop® 250mg or one tablet Haemostop® 500mg every 4 to 6 hours until there is no further risk of bleeding. - By local application: A tampon of cotton-wool is soaked with the content of one ampoule and applied to the bleeding area or placed in the tooth socket after a dental extraction. The application may be repeated if necessary and may also be associated with oral or parenteral administration. Basem Wadea
  • 9. Haemostop® Dosage & Administration: Curative treatment: According to the severity of the case: - Before operation: 2 ampoules I.V. or I.M. 1 hour before operation or 2 or 3 tablets Haemostop® 250mg 3 hours before operation. - During operation: 2 ampoules I.V. to be repeated if necessary. - After operation: 1 ampoule or 2 tablets Haemostop® 250mg or one tablet Haemostop® 500mg every 6 hours as long as the risk of bleeding persists. Basem Wadea
  • 10. Haemostop® How supplied: Ampoules: Ampoules of 2ml in packs of 3 Ampoules. Tablets : Strips of 10 Tablets Haemostop® 250mg in packs of 1 or 2 strips. Strips of 5 Tablets Haemostop® 500mg in packs of 2 strips. Basem