Center for Brain, Biology, &           Behavior     Interdisciplinary Research Center                Dennis L. Molfese, Ph...
Acknowledgements    –Cathryn Cortesa, BA    –Nicole Earnest    –Caitlin Hudac, MA    –Kathleen Kelsey, MA    –Srinivas Kot...
Philosophy of The CenterFoster Interdisciplinary Collaborations.Provide Assess to BOTH Equipment & Training.Lead Paradigm ...
New Stadium AdditionsCenter for Brain, Biology,& Behavior                   Health & Performance                          ...
Athletics/Academics Collaboration:          An Unprecedented Initiative• Informs:   –Medical & Behavioral Science   –Athle...
BIG 10 - Ivy League        Concussion Research            Collaboration•   Consortium of 13 University Research & Sport   ...
Unprecedented New Information • Screen Athletes Before Season (baseline) • Track Performance, Neurocognition & Brain Measu...
Facilities
1st Floor
2nd FloorReception
2nd Floor
Internal Stairway Connecting 2nd and 3rd Floors
3rd Floor
Science Work Group Areas for 2nd and 3rd Floors
Training Plan
Model for Training in Brain Imaging             Techniques1. Workshop Introduction to Theory, Methods,   Literature, Analy...
CB3 Training To Date         October 1, 2010 - August, 2012•   8 Two-Day Workshop:         227 Faculty & Students•   Advan...
Current Trainees = 26        08-22-2012
Available Technologies                  fMRI    High Density Infant & Adult NIRS        High-Density EEG/ERP Transcranial ...
fMRI - functional Magnetic Resonance Imaging                                Siemens 3 Tesla                 Structure     ...
fMRI - functional Magnetic Resonance Imaging                   QuickTime™ and a                    decompressor           ...
Diffusion Tensor Imaging
Magnetic Resonance Spectroscopy
fMRI Imaging  Attachment Dyslexia
Balance Lab
Videonystagmography (VNG)Gait Testing               Rotational Chair
Balance FunctionTesting    Subjective Visual Vertical                                 Functional Evaluation of Vestibulo-O...
NIRS - Near-Infrared Spectroscopy
TMS - Transcranial Magnetic Stimulation Machine
High-Density ERP/EEG      Event-Related Potentials (ERP)                                           QuickTime™ and a       ...
Front of Head NEWBORNLeft Side          QuickTime™ and a           Right Side                 Video decompressor          ...
Front of Head        AdultLeft Side                       Right Side    +    -                Back of Head
Learning alters brain organization for acquisition               of new information                                       ...
Eye TrackerEye Tracker + ERP net   Eye Tracking Information
Intervention
ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent         Language Gains Following 4 Month Intervention   ...
Concussion Intervention                                     T    Training Task          ResultsAdditional Benefits
Concussion
Issues in Assessing Sports Concussion•   1. Little information on brain & behavior prior to concussion.•   2. Little long-...
Brain Deformation Following Side “Hit”                                 Direction                                __Top View...
Brain Deformation Following Side “Hit”                                 Direction                                __Top View...
Vestibular Tests May Help to Identify        and Manage ConcussionJulie Honaker, Ph.D.
Sports ConcussionWorking Memory: 2-back                Match   Nonmatch                Match   Nonmatch  N2       N400
Self-reported symptoms & N2                     No history of persistent   History of persistent   2.5 nA                 ...
20-40% with TBI experience vision-disorders  Normal Visual World     World at an Angle                                   Q...
QuickTime™ and a MPEG-4 Video decompressorare needed to see this picture.
Future Possibilities•   Use brain imaging procedures to identify distortions    produced by brain injury.•   Identify inte...
Questions ???©2012 The Board of Regents of the University of Nebraska. All rights reserved.
fMRI - functional Magnetic Resonance Imaging
High-Density ERP/EEG:   Newborn Infant                QuickTime™ and a              Cinepak decompressor         are neede...
High-Density ERP/EEG: Adult          QuickTime™ and a        H.263 decompressor   are needed to see this picture.
Function      fMRI      Tracks      Blood      Flow in      Brain                   DTI                                   ...
Key et al., In press                       55
CB3 Facilities and Agenda
CB3 Facilities and Agenda
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CB3 Facilities and Agenda

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Presentation from Dennis Molfese at the Building Research Collaborations Workshop, Aug. 23, 2012

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  • 46 lab rooms Dooug Granger & Brandon Rigoni Sherri Jones Department of Special Education and Speech ... ‎
  • Julie Honacker Department of Special Education and Speech ... ‎:
  • An athlete’s ability to keep his/her eye on the ball (aka gaze stability) depends on a healthy balance system. Preliminary analysis of Dr. Honaker’s work suggests that vestibular testing can identify athletes with a previous concussion. Adding objective testing into the concussion evaluation and management protocol may be able to better identify and management the effects of concussion. Further evaluation of this finding is the aim of future work in her lab within the CB3, with more sophisticated vestibular and balance function tests. Figure: ROC analysis indicates that a vestibular test called Gaze stabilization is a useful measure for identifying athletes with a history of concussion
  • Kick Some Serious Neuro Butt
  • CB3 Facilities and Agenda

    1. 1. Center for Brain, Biology, & Behavior Interdisciplinary Research Center Dennis L. Molfese, Ph.D. Mildred Francis Thompson Professor Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium Editor-In-Chief: Developmental Neuropsychology Director: Developmental Neuroscience Lab University of Nebraska -Lincoln
    2. 2. Acknowledgements –Cathryn Cortesa, BA –Nicole Earnest –Caitlin Hudac, MA –Kathleen Kelsey, MA –Srinivas Kota, Ph.D. –Christopher Rudasill, MFA –Nathan Petro, B.A. –Victoria Molfese, Ph.D.
    3. 3. Philosophy of The CenterFoster Interdisciplinary Collaborations.Provide Assess to BOTH Equipment & Training.Lead Paradigm Shift Within The Neurosciences: –- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty. –- Address Characteristics of Processing In and Between Brain Regions.
    4. 4. New Stadium AdditionsCenter for Brain, Biology,& Behavior Health & Performance Research Lab
    5. 5. Athletics/Academics Collaboration: An Unprecedented Initiative• Informs: –Medical & Behavioral Science –Athletic & Academic Training & Competition –Safety –Innovations
    6. 6. BIG 10 - Ivy League Concussion Research Collaboration• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools• Coaches• Trainers• Behavior & Brain Imaging Researchers• Shared data base for images, behavior data, test procedures & programs• Increasing external grant funding.
    7. 7. Unprecedented New Information • Screen Athletes Before Season (baseline) • Track Performance, Neurocognition & Brain Measures•Head Injured & Matched Controls•Assess Impact of Multiple Concussion•Shared Database Across Conferences • Design Interventions • Improve Equipment Design • Develop Concussion Awareness Programs
    8. 8. Facilities
    9. 9. 1st Floor
    10. 10. 2nd FloorReception
    11. 11. 2nd Floor
    12. 12. Internal Stairway Connecting 2nd and 3rd Floors
    13. 13. 3rd Floor
    14. 14. Science Work Group Areas for 2nd and 3rd Floors
    15. 15. Training Plan
    16. 16. Model for Training in Brain Imaging Techniques1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)2. Consult on research design3. Hands-on training with equipment for setup, data collection, data processing & analysis.4. Assistance with: a. Data analyses b. Conference presentations c. Journal article drafts4. Grant submissions GOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.
    17. 17. CB3 Training To Date October 1, 2010 - August, 2012• 8 Two-Day Workshop: 227 Faculty & Students• Advanced Imaging Training: 69 Faculty & Students• Current Research Studies: 12 Projects• Department Presentations: 38
    18. 18. Current Trainees = 26 08-22-2012
    19. 19. Available Technologies fMRI High Density Infant & Adult NIRS High-Density EEG/ERP Transcranial Magnetic Stimulation -TMS Behavior Science Labs Balance Labs Computer Labs Developmental Labs Endocrine Lab Eye Tracking Labs Genetics Lab
    20. 20. fMRI - functional Magnetic Resonance Imaging Siemens 3 Tesla Structure 70 cm bore DTI Function
    21. 21. fMRI - functional Magnetic Resonance Imaging QuickTime™ and a decompressor are needed to see this picture.
    22. 22. Diffusion Tensor Imaging
    23. 23. Magnetic Resonance Spectroscopy
    24. 24. fMRI Imaging Attachment Dyslexia
    25. 25. Balance Lab
    26. 26. Videonystagmography (VNG)Gait Testing Rotational Chair
    27. 27. Balance FunctionTesting Subjective Visual Vertical Functional Evaluation of Vestibulo-Ocu Reflex (VOR)
    28. 28. NIRS - Near-Infrared Spectroscopy
    29. 29. TMS - Transcranial Magnetic Stimulation Machine
    30. 30. High-Density ERP/EEG Event-Related Potentials (ERP) QuickTime™ and a QuickTime™ and a Cinepak decompressor are needed to see this picture. H.263 decompressor are needed to see this picture.Newborn Infant Adult
    31. 31. Front of Head NEWBORNLeft Side QuickTime™ and a Right Side Video decompressor are needed to see this picture. + - Back of Head
    32. 32. Front of Head AdultLeft Side Right Side + - Back of Head
    33. 33. Learning alters brain organization for acquisition of new information Same Shape Matching Task Different Low GRTR High GRTR [GRTR less than 11] [GRTR more than 11] QuickTime™ and a QuickTime™ and a Video decompressor Video decompressor are needed to see this picture. are needed to see this picture. Molfese et al, 2008
    34. 34. Eye TrackerEye Tracker + ERP net Eye Tracking Information
    35. 35. Intervention
    36. 36. ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent Language Gains Following 4 Month Intervention Ability to discriminate /da/ from /ga/ Yoder, Molfese & Camarata, In Press
    37. 37. Concussion Intervention T Training Task ResultsAdditional Benefits
    38. 38. Concussion
    39. 39. Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to concussion.• 2. Little long-term follow-up following concussion using standardized testing.• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).• 4. Little information available regarding prior head injuries.• 5. Falsification of pre-season tests by athletes.• 6. Pressure to resume play following possible head injury.• 7. No research-based information regarding when players can be safely returned to play.
    40. 40. Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of ForcePellman et al., 2006
    41. 41. Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of Force Force can producePellman et al., 2006 shearing
    42. 42. Vestibular Tests May Help to Identify and Manage ConcussionJulie Honaker, Ph.D.
    43. 43. Sports ConcussionWorking Memory: 2-back Match Nonmatch Match Nonmatch N2 N400
    44. 44. Self-reported symptoms & N2 No history of persistent History of persistent 2.5 nA headache (n=16) headache (n=19) .01 nA Match N2 Nonmatch
    45. 45. 20-40% with TBI experience vision-disorders Normal Visual World World at an Angle QuickTime™ and a GIF decompressor are needed to see this picture. Post-Trauma Vision Syndrome Visual Midline Shift Syndrome Hudac et al, 2011
    46. 46. QuickTime™ and a MPEG-4 Video decompressorare needed to see this picture.
    47. 47. Future Possibilities• Use brain imaging procedures to identify distortions produced by brain injury.• Identify intervention that can produce more normal neural processing.• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.
    48. 48. Questions ???©2012 The Board of Regents of the University of Nebraska. All rights reserved.
    49. 49. fMRI - functional Magnetic Resonance Imaging
    50. 50. High-Density ERP/EEG: Newborn Infant QuickTime™ and a Cinepak decompressor are needed to see this picture. Event-Related Potentials (ERP)
    51. 51. High-Density ERP/EEG: Adult QuickTime™ and a H.263 decompressor are needed to see this picture.
    52. 52. Function fMRI Tracks Blood Flow in Brain DTI QuickTime™ and a Photo - JPEG decompres s or are needed to see this pic ture.ERP Structure 54
    53. 53. Key et al., In press 55

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