46 lab rooms Dooug Granger & Brandon Rigoni Sherri Jones Department of Special Education and Speech ...
Julie Honacker Department of Special Education and Speech ... :
An athlete’s ability to keep his/her eye on the ball (aka gaze stability) depends on a healthy balance system. Preliminary analysis of Dr. Honaker’s work suggests that vestibular testing can identify athletes with a previous concussion. Adding objective testing into the concussion evaluation and management protocol may be able to better identify and management the effects of concussion. Further evaluation of this finding is the aim of future work in her lab within the CB3, with more sophisticated vestibular and balance function tests. Figure: ROC analysis indicates that a vestibular test called Gaze stabilization is a useful measure for identifying athletes with a history of concussion
Kick Some Serious Neuro Butt
CB3 Facilities and Agenda
Center for Brain, Biology, & Behavior Interdisciplinary Research Center Dennis L. Molfese, Ph.D. Mildred Francis Thompson Professor Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium Editor-In-Chief: Developmental Neuropsychology Director: Developmental Neuroscience Lab University of Nebraska -Lincoln
Acknowledgements –Cathryn Cortesa, BA –Nicole Earnest –Caitlin Hudac, MA –Kathleen Kelsey, MA –Srinivas Kota, Ph.D. –Christopher Rudasill, MFA –Nathan Petro, B.A. –Victoria Molfese, Ph.D.
Philosophy of The CenterFoster Interdisciplinary Collaborations.Provide Assess to BOTH Equipment & Training.Lead Paradigm Shift Within The Neurosciences: –- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty. –- Address Characteristics of Processing In and Between Brain Regions.
New Stadium AdditionsCenter for Brain, Biology,& Behavior Health & Performance Research Lab
Athletics/Academics Collaboration: An Unprecedented Initiative• Informs: –Medical & Behavioral Science –Athletic & Academic Training & Competition –Safety –Innovations
BIG 10 - Ivy League Concussion Research Collaboration• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools• Coaches• Trainers• Behavior & Brain Imaging Researchers• Shared data base for images, behavior data, test procedures & programs• Increasing external grant funding.
Unprecedented New Information • Screen Athletes Before Season (baseline) • Track Performance, Neurocognition & Brain Measures•Head Injured & Matched Controls•Assess Impact of Multiple Concussion•Shared Database Across Conferences • Design Interventions • Improve Equipment Design • Develop Concussion Awareness Programs
Model for Training in Brain Imaging Techniques1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)2. Consult on research design3. Hands-on training with equipment for setup, data collection, data processing & analysis.4. Assistance with: a. Data analyses b. Conference presentations c. Journal article drafts4. Grant submissions GOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.
CB3 Training To Date October 1, 2010 - August, 2012• 8 Two-Day Workshop: 227 Faculty & Students• Advanced Imaging Training: 69 Faculty & Students• Current Research Studies: 12 Projects• Department Presentations: 38
TMS - Transcranial Magnetic Stimulation Machine
High-Density ERP/EEG Event-Related Potentials (ERP) QuickTime™ and a QuickTime™ and a Cinepak decompressor are needed to see this picture. H.263 decompressor are needed to see this picture.Newborn Infant Adult
Front of Head NEWBORNLeft Side QuickTime™ and a Right Side Video decompressor are needed to see this picture. + - Back of Head
Front of Head AdultLeft Side Right Side + - Back of Head
Learning alters brain organization for acquisition of new information Same Shape Matching Task Different Low GRTR High GRTR [GRTR less than 11] [GRTR more than 11] QuickTime™ and a QuickTime™ and a Video decompressor Video decompressor are needed to see this picture. are needed to see this picture. Molfese et al, 2008
Eye TrackerEye Tracker + ERP net Eye Tracking Information
Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to concussion.• 2. Little long-term follow-up following concussion using standardized testing.• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).• 4. Little information available regarding prior head injuries.• 5. Falsification of pre-season tests by athletes.• 6. Pressure to resume play following possible head injury.• 7. No research-based information regarding when players can be safely returned to play.
Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of ForcePellman et al., 2006
Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of Force Force can producePellman et al., 2006 shearing
Vestibular Tests May Help to Identify and Manage ConcussionJulie Honaker, Ph.D.
Sports ConcussionWorking Memory: 2-back Match Nonmatch Match Nonmatch N2 N400
Self-reported symptoms & N2 No history of persistent History of persistent 2.5 nA headache (n=16) headache (n=19) .01 nA Match N2 Nonmatch
20-40% with TBI experience vision-disorders Normal Visual World World at an Angle QuickTime™ and a GIF decompressor are needed to see this picture. Post-Trauma Vision Syndrome Visual Midline Shift Syndrome Hudac et al, 2011
QuickTime™ and a MPEG-4 Video decompressorare needed to see this picture.
Future Possibilities• Use brain imaging procedures to identify distortions produced by brain injury.• Identify intervention that can produce more normal neural processing.• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.