CB3 Facilities and Agenda
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CB3 Facilities and Agenda

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Presentation from Dennis Molfese at the Building Research Collaborations Workshop, Aug. 23, 2012

Presentation from Dennis Molfese at the Building Research Collaborations Workshop, Aug. 23, 2012

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  • 46 lab rooms Dooug Granger & Brandon Rigoni Sherri Jones Department of Special Education and Speech ... ‎
  • Julie Honacker Department of Special Education and Speech ... ‎:
  • An athlete’s ability to keep his/her eye on the ball (aka gaze stability) depends on a healthy balance system. Preliminary analysis of Dr. Honaker’s work suggests that vestibular testing can identify athletes with a previous concussion. Adding objective testing into the concussion evaluation and management protocol may be able to better identify and management the effects of concussion. Further evaluation of this finding is the aim of future work in her lab within the CB3, with more sophisticated vestibular and balance function tests. Figure: ROC analysis indicates that a vestibular test called Gaze stabilization is a useful measure for identifying athletes with a history of concussion
  • Kick Some Serious Neuro Butt

CB3 Facilities and Agenda CB3 Facilities and Agenda Presentation Transcript

  • Center for Brain, Biology, & Behavior Interdisciplinary Research Center Dennis L. Molfese, Ph.D. Mildred Francis Thompson Professor Director: Center for Brain, Biology & BehaviorDirector: Big Ten/CIC Traumatic Brain Injury Research Consortium Editor-In-Chief: Developmental Neuropsychology Director: Developmental Neuroscience Lab University of Nebraska -Lincoln
  • Acknowledgements –Cathryn Cortesa, BA –Nicole Earnest –Caitlin Hudac, MA –Kathleen Kelsey, MA –Srinivas Kota, Ph.D. –Christopher Rudasill, MFA –Nathan Petro, B.A. –Victoria Molfese, Ph.D.
  • Philosophy of The CenterFoster Interdisciplinary Collaborations.Provide Assess to BOTH Equipment & Training.Lead Paradigm Shift Within The Neurosciences: –- Move from “neural phrenology” to Understanding Brain’s Neural Spatial & Temporal Interconnectivty. –- Address Characteristics of Processing In and Between Brain Regions.
  • New Stadium AdditionsCenter for Brain, Biology,& Behavior Health & Performance Research Lab
  • Athletics/Academics Collaboration: An Unprecedented Initiative• Informs: –Medical & Behavioral Science –Athletic & Academic Training & Competition –Safety –Innovations
  • BIG 10 - Ivy League Concussion Research Collaboration• Consortium of 13 University Research & Sport Programs with BIG 10 CIC + 8 Ivy League Schools• Coaches• Trainers• Behavior & Brain Imaging Researchers• Shared data base for images, behavior data, test procedures & programs• Increasing external grant funding.
  • Unprecedented New Information • Screen Athletes Before Season (baseline) • Track Performance, Neurocognition & Brain Measures•Head Injured & Matched Controls•Assess Impact of Multiple Concussion•Shared Database Across Conferences • Design Interventions • Improve Equipment Design • Develop Concussion Awareness Programs
  • Facilities
  • 1st Floor
  • 2nd FloorReception
  • 2nd Floor
  • Internal Stairway Connecting 2nd and 3rd Floors
  • 3rd Floor
  • Science Work Group Areas for 2nd and 3rd Floors
  • Training Plan
  • Model for Training in Brain Imaging Techniques1. Workshop Introduction to Theory, Methods, Literature, Analyses (2-days)2. Consult on research design3. Hands-on training with equipment for setup, data collection, data processing & analysis.4. Assistance with: a. Data analyses b. Conference presentations c. Journal article drafts4. Grant submissions GOAL: Establish Dominance in Mainstream Research Areas Through Research & Grant Activities.
  • CB3 Training To Date October 1, 2010 - August, 2012• 8 Two-Day Workshop: 227 Faculty & Students• Advanced Imaging Training: 69 Faculty & Students• Current Research Studies: 12 Projects• Department Presentations: 38
  • Current Trainees = 26 08-22-2012
  • Available Technologies fMRI High Density Infant & Adult NIRS High-Density EEG/ERP Transcranial Magnetic Stimulation -TMS Behavior Science Labs Balance Labs Computer Labs Developmental Labs Endocrine Lab Eye Tracking Labs Genetics Lab
  • fMRI - functional Magnetic Resonance Imaging Siemens 3 Tesla Structure 70 cm bore DTI Function
  • fMRI - functional Magnetic Resonance Imaging QuickTime™ and a decompressor are needed to see this picture.
  • Diffusion Tensor Imaging
  • Magnetic Resonance Spectroscopy
  • fMRI Imaging Attachment Dyslexia
  • Balance Lab
  • Videonystagmography (VNG)Gait Testing Rotational Chair
  • Balance FunctionTesting Subjective Visual Vertical Functional Evaluation of Vestibulo-Ocu Reflex (VOR)
  • NIRS - Near-Infrared Spectroscopy
  • TMS - Transcranial Magnetic Stimulation Machine
  • High-Density ERP/EEG Event-Related Potentials (ERP) QuickTime™ and a QuickTime™ and a Cinepak decompressor are needed to see this picture. H.263 decompressor are needed to see this picture.Newborn Infant Adult
  • Front of Head NEWBORNLeft Side QuickTime™ and a Right Side Video decompressor are needed to see this picture. + - Back of Head
  • Front of Head AdultLeft Side Right Side + - Back of Head
  • Learning alters brain organization for acquisition of new information Same Shape Matching Task Different Low GRTR High GRTR [GRTR less than 11] [GRTR more than 11] QuickTime™ and a QuickTime™ and a Video decompressor Video decompressor are needed to see this picture. are needed to see this picture. Molfese et al, 2008
  • Eye TrackerEye Tracker + ERP net Eye Tracking Information
  • Intervention
  • ERPs in 2 to 4-Year-Old Preschool SLI Children Predict Subsequent Language Gains Following 4 Month Intervention Ability to discriminate /da/ from /ga/ Yoder, Molfese & Camarata, In Press
  • Concussion Intervention T Training Task ResultsAdditional Benefits
  • Concussion
  • Issues in Assessing Sports Concussion• 1. Little information on brain & behavior prior to concussion.• 2. Little long-term follow-up following concussion using standardized testing.• 3. Tests not comprehensive (e.g., ImPACT not effective in measuring attention, working memory).• 4. Little information available regarding prior head injuries.• 5. Falsification of pre-season tests by athletes.• 6. Pressure to resume play following possible head injury.• 7. No research-based information regarding when players can be safely returned to play.
  • Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of ForcePellman et al., 2006
  • Brain Deformation Following Side “Hit” Direction __Top View < of Force Direction __Side View < of Force Force can producePellman et al., 2006 shearing
  • Vestibular Tests May Help to Identify and Manage ConcussionJulie Honaker, Ph.D.
  • Sports ConcussionWorking Memory: 2-back Match Nonmatch Match Nonmatch N2 N400
  • Self-reported symptoms & N2 No history of persistent History of persistent 2.5 nA headache (n=16) headache (n=19) .01 nA Match N2 Nonmatch
  • 20-40% with TBI experience vision-disorders Normal Visual World World at an Angle QuickTime™ and a GIF decompressor are needed to see this picture. Post-Trauma Vision Syndrome Visual Midline Shift Syndrome Hudac et al, 2011
  • QuickTime™ and a MPEG-4 Video decompressorare needed to see this picture.
  • Future Possibilities• Use brain imaging procedures to identify distortions produced by brain injury.• Identify intervention that can produce more normal neural processing.• Use the successful intervention to enable individual to perceive and interact with the world in more normal fashion.
  • Questions ???©2012 The Board of Regents of the University of Nebraska. All rights reserved.
  • fMRI - functional Magnetic Resonance Imaging
  • High-Density ERP/EEG: Newborn Infant QuickTime™ and a Cinepak decompressor are needed to see this picture. Event-Related Potentials (ERP)
  • High-Density ERP/EEG: Adult QuickTime™ and a H.263 decompressor are needed to see this picture.
  • Function fMRI Tracks Blood Flow in Brain DTI QuickTime™ and a Photo - JPEG decompres s or are needed to see this pic ture.ERP Structure 54
  • Key et al., In press 55