Sreeni Labs is a contract research and manufacturing organization located in Hyderabad, India. It was established in 2007 and provides medicinal chemistry, process development, and manufacturing services to support pharmaceutical drug discovery and development. The company has laboratory, pilot plant, and analytical equipment for synthetic chemistry work up to the kilogram scale. Sreeni Labs aims to be a trusted global partner for pharmaceutical clients by providing innovative and cost-effective chemistry services.

1. Sreeni Labs
…Adding value
Sreeni Labs Private Limited
Road No:12, Plot NO: 24,25 & 26
IDA, Nacharam,
Hyderabad - 500 076 Telangana, India
e-mail: Info@sreenilabs.com

2. • Established in 2007
• Located in Hyderabad, India
• Contract Research and Manufacturing
• FTE and Fee for Service
About us
Vision
• “To become trusted
partner globally for
pharmaceutical companies
in advancing their
discovery and development
efforts to deliver medicines
that protect and improve
human and animal health
conditions”
Mission
• “To provide innovative,
value-added and cost
effective synthetic,
medicinal and process
chemistry services &
Supply quality products
that help speed up drug
discovery and development
programs”
Values
• Integrity
• Respect
• Customer focus
• Innovation

3. Medicinal Chemistry Process Development Manufacturing
• Medicinal Chemistry: Design & synthesize select medchem target compounds,
analogs & compound libararies.
• Enabling Chemistry: Design strategic synthetic routes to NCEs, new scaffolds/
platforms & key advanced intermediates and demonstrate on multi-gram scale
to enable rapid preclinical development.
• Route Selection: Design & demonstrate synthetic routes with a potential to
become commercial route to clinical candidates and leading key intermediates.
• Route Development: Develop an existing or chosen route from a proof of
concept, and transfer the technology to pilot plant for a successful scale up
with a good control on impurities.
• Custom Synthesis & Manufacturing: Synthesize building blocks, impurities,
metabolites, reference standards, bench mark compounds, and rare chemicals.
Supporting Drug Discovery and DevelopmentSupporting Discovery to Development
• Medicinal Chemistry: Design & synthesize select medchem target compounds,
analogs & compound libararies.
• Enabling Chemistry: Design strategic synthetic routes to NCEs, new scaffolds/
platforms & key advanced intermediates and demonstrate on multi-gram scale
to enable rapid preclinical development.
• Route Selection: Design & demonstrate synthetic routes with a potential to
become commercial route to clinical candidates and leading key intermediates.
• Route Development: Develop an existing or chosen route from a proof of
concept, and transfer the technology to pilot plant for a successful scale up
with a good control on impurities.
• Custom Synthesis & Manufacturing: Synthesize building blocks, impurities,
metabolites, reference standards, bench mark compounds, and rare chemicals.

4. Solid
infrastructure
Customer
centric
culture
Scientific
skills
key
differentiator
Sreeni
Labs
Why Sreeni Labs
Customer
centric
culture
Efficient
Project
Management
Scientific
skills
key
differentiator
Sreeni
Labs

5. Lab and Scale up equipment
• Bench top fume hoods fitted with air, N2, water, vacuum lines
• Distillation fume hoods
• Rota vapors/ High vacuum and diaphragm pumps
• Parr hydrogenation apparatus/ 2L Autoclave (SS)
• Ice machine, dry ice & Liquid Nitrogen
• UV cabinets and balances
• 20 L Rotary Evaporator
Infrastructure – Lab scale
Lab and Scale up equipment
• Bench top fume hoods fitted with air, N2, water, vacuum lines
• Distillation fume hoods
• Rota vapors/ High vacuum and diaphragm pumps
• Parr hydrogenation apparatus/ 2L Autoclave (SS)
• Ice machine, dry ice & Liquid Nitrogen
• UV cabinets and balances
• 20 L Rotary Evaporator

6. • LCMS (Agilent)
• HPLC (Waters) / GC (shimadzu)
• FT IR (Thermo-Fisher Scientific)/ Melting Point (Buchi)
• Water purification (Millipore)
• Micro balances/ Polarimeter / pH meter/ Sonicator/ Karl-Fischer Titrator
• Access to 300 MHz NMR (Fee for service basis)
Infrastructure – Analytical
• LCMS (Agilent)
• HPLC (Waters) / GC (shimadzu)
• FT IR (Thermo-Fisher Scientific)/ Melting Point (Buchi)
• Water purification (Millipore)
• Micro balances/ Polarimeter / pH meter/ Sonicator/ Karl-Fischer Titrator
• Access to 300 MHz NMR (Fee for service basis)

7. Multi purpose pilot plant:
• All Glass reactors: 100 L (2), 50L (1) & 20L (1)
• SS Reactors: 500L
• High Vaccum Distillation
• Nutch Filters
• Vaccum Tray Dryer (SS)
• Water Jet Vacum Pump
• Cooling Tower
• SS Autoclave (2 L)
Infrastructure – Pilot Plant
Multi purpose pilot plant:
• All Glass reactors: 100 L (2), 50L (1) & 20L (1)
• SS Reactors: 500L
• High Vaccum Distillation
• Nutch Filters
• Vaccum Tray Dryer (SS)
• Water Jet Vacum Pump
• Cooling Tower
• SS Autoclave (2 L)

8. Bulk Production Operations**:
• SS Reactors: 1 KL to 10 KL
• GL Reactors: 1.6 KL to 6 KL
• Associated utilities to carry out all kinds of reactions
**Note: All commercial scale operations are carried out at our alliance
partner(s) facility on exclusive basis
Infrastructure - Manufacturing
Bulk Production Operations**:
• SS Reactors: 1 KL to 10 KL
• GL Reactors: 1.6 KL to 6 KL
• Associated utilities to carry out all kinds of reactions
**Note: All commercial scale operations are carried out at our alliance
partner(s) facility on exclusive basis

9. Lab Safety
Safety is number one priority
Labs are fitted with Fire
extinguishers, eye washer etc.,
Wearing lab coats, safety glasses,
gloves compulsory
Safety shields are used for hazardous
rxns and high temp rxns
All personal go through general
laboratory safety training at the time
of induction and also refreshed
periodically
Waste Treatment & Disposal
All the liquid waste segregated as
chlorinated / non-chlorinated types
Solid waste like silica gel, sodium
sulfate etc. kept separately
Aqueous waste evaporated or
disposed at JETL and solid waste
disposed at a Gov.t regulated
disposal site
Infrastructure – Safety and Environment
Safety is number one priority
Labs are fitted with Fire
extinguishers, eye washer etc.,
Wearing lab coats, safety glasses,
gloves compulsory
Safety shields are used for hazardous
rxns and high temp rxns
All personal go through general
laboratory safety training at the time
of induction and also refreshed
periodically
All the liquid waste segregated as
chlorinated / non-chlorinated types
Solid waste like silica gel, sodium
sulfate etc. kept separately
Aqueous waste evaporated or
disposed at JETL and solid waste
disposed at a Gov.t regulated
disposal site

10. Confidentiality
• IP belongs to customer
• Data protection measures
• Upfront discussion and agreement
• Any issues will be intimated
immediately with a proposed solution
Customer Centric approach
Customer Cost
effectiveness
Thorough Data
and
Documentation
Meeting
Timelines
• Most efficient synthetic routes
• Optimization using less expensive
reagents
• Complete experimental
procedures and spectral data for
use in regulatory filings

11. Each Project is given a
project code
All projects reviewed by Project
in Charge every 15 days
Client receives weekly/
biweekly progress reports
Purity of final compounds discussed with
client before shipping in case of problem in
achieving Targeted purity
Data cards are prepared for each step of
the synthetic process and compiled for
Final report
Efficient Project Management
Project planning by
Scientists and execution
Scientists follow up the
progress on a daily
basis
Chemists record their
observations in dedicated Lab
Note books
All projects reviewed by Project
in Charge every 15 days
Data cards are prepared for each step of
the synthetic process and compiled for
Final report
Final reports sent to Client for each project
which includes synthetic scheme,
experimental procedure, spectral data such
as IR, 1H NMR, Mass and HPLC in electronic
form.

12. • Proven track record in the design and development of practical, safe, economical and scalable
routes to a variety of New Chemical Entities & natural products synthesis
• Generation of enolates using LDA or LHMDS & preparation of enamine
• Suzuki, Buchwald chemistry using Pd based reagents
• Various acid-amine / acid- alcohol condensations
• Reductive aminations using NaBH3CN, NaBH (OAc)3, etc.
• Grignard & Wittig reactions, Mitsunobu rxns, protection & deprotections
• General reactions like oxidations using PCC, PDC, SeO2, Swern oxdn and several other reagents;
• Reductions using Metal / acid, LAH, NaBH4, Dibal-H etc.,
• Hydrogenation using 250 mL- 2L Parr hydrogenation apparatus
• Hazardous Chemistry such as nitration, Cyanations, Phosgene & liq. ammonia reactions
• Asymmetric synthesis, Chemical Resolutions
• Use of Amino acids in making chiral building blocks
• Process impurities & Metabolites
• Total synthesis of terpenoids & Alkaloids
Scientific Skills – A Glimpse
• Proven track record in the design and development of practical, safe, economical and scalable
routes to a variety of New Chemical Entities & natural products synthesis
• Generation of enolates using LDA or LHMDS & preparation of enamine
• Suzuki, Buchwald chemistry using Pd based reagents
• Various acid-amine / acid- alcohol condensations
• Reductive aminations using NaBH3CN, NaBH (OAc)3, etc.
• Grignard & Wittig reactions, Mitsunobu rxns, protection & deprotections
• General reactions like oxidations using PCC, PDC, SeO2, Swern oxdn and several other reagents;
• Reductions using Metal / acid, LAH, NaBH4, Dibal-H etc.,
• Hydrogenation using 250 mL- 2L Parr hydrogenation apparatus
• Hazardous Chemistry such as nitration, Cyanations, Phosgene & liq. ammonia reactions
• Asymmetric synthesis, Chemical Resolutions
• Use of Amino acids in making chiral building blocks
• Process impurities & Metabolites
• Total synthesis of terpenoids & Alkaloids

13. • Synthesized ~60 Retinal analogs on 100mg scale, 50 reference compounds from 100mg to 1g scale.
• In four months time, developed a novel non Suzuki route to an aryl-heteroaryl API in phase II, and
avoided use of palladium catalyst &expensive ligands. This resulted in cost reduction of API by 70%.
• Designed & developed an acid-base chemistry route to an oncology product and lowered the
number of steps by 50% and scaled up on multi kilo scale. Avoided use of palladium catalyst and
expensive ligands and also reduced the cycle time by 65%.
• Proposed and developed a novel route for an API and avoided use of reagents like sodium azide,
methyl iodide and zinc chloride towards the end of synthesis. This helped to lower the synthetic
steps and also avoided the need to test for potential mutagens in the API.
• In 6 weeks time designed & developed a novel synthetic route for a key intermediate in SAR
program. A well established major CRO couldn’t make this product after 4 months of 2 FTE efforts.
• Developed novel process for a tetrapeptide synthesis in solution phase. Chemistry was scaled up on
100kg scale.
• In two months time made variously substituted >50 sulfonyl fluorides on 25 to 50g scale.
• Synthesized more than 400 building blocks from 10g to 1kg scale comprising derivatives of
thiophenes, imidazoles, oxazoles, isoxazoles, quinolines and pyridines.
Scientific Skills – A Glimpse
• Synthesized ~60 Retinal analogs on 100mg scale, 50 reference compounds from 100mg to 1g scale.
• In four months time, developed a novel non Suzuki route to an aryl-heteroaryl API in phase II, and
avoided use of palladium catalyst &expensive ligands. This resulted in cost reduction of API by 70%.
• Designed & developed an acid-base chemistry route to an oncology product and lowered the
number of steps by 50% and scaled up on multi kilo scale. Avoided use of palladium catalyst and
expensive ligands and also reduced the cycle time by 65%.
• Proposed and developed a novel route for an API and avoided use of reagents like sodium azide,
methyl iodide and zinc chloride towards the end of synthesis. This helped to lower the synthetic
steps and also avoided the need to test for potential mutagens in the API.
• In 6 weeks time designed & developed a novel synthetic route for a key intermediate in SAR
program. A well established major CRO couldn’t make this product after 4 months of 2 FTE efforts.
• Developed novel process for a tetrapeptide synthesis in solution phase. Chemistry was scaled up on
100kg scale.
• In two months time made variously substituted >50 sulfonyl fluorides on 25 to 50g scale.
• Synthesized more than 400 building blocks from 10g to 1kg scale comprising derivatives of
thiophenes, imidazoles, oxazoles, isoxazoles, quinolines and pyridines.
Clients: US/Europe/Domestic based pharma ; References can be provided upon request

14. Lab Capacity:
• SREENI Labs facility can accommodate 80 to 100 Scientists / Chemists. Total
five R&D wet Labs, Analaytical lab & a Scale up lab. Each R&D lab can
accommodate 15-16 People.
• Present total SREENI Labs staff is 35. Out of five Labs, two labs are in operation
and are occupied with 22 chemists. 3 chemists are working in kilo lab. Total
supporting staff is 10 people which include the office staff.
• SREENI Labs can accommodate still another 70 people easily and can execute
work as it is having a proven record with the able leadership.
• SREENI Labs uses Reaxys and electronic journals for its literature requirements.
• SREENI Labs utilizes IICT, Hyderabad facility for ant additional literature and any
special equipment needs.
Lab Capability – A Glimpse
Lab Capacity:
• SREENI Labs facility can accommodate 80 to 100 Scientists / Chemists. Total
five R&D wet Labs, Analaytical lab & a Scale up lab. Each R&D lab can
accommodate 15-16 People.
• Present total SREENI Labs staff is 35. Out of five Labs, two labs are in operation
and are occupied with 22 chemists. 3 chemists are working in kilo lab. Total
supporting staff is 10 people which include the office staff.
• SREENI Labs can accommodate still another 70 people easily and can execute
work as it is having a proven record with the able leadership.
• SREENI Labs uses Reaxys and electronic journals for its literature requirements.
• SREENI Labs utilizes IICT, Hyderabad facility for ant additional literature and any
special equipment needs.

15. Recent Photographs of new premises– A Glimpse
Front view of the SREENI LABS
Main corridor in the first floor to enter into the
Labs, QC and other FacilitiesConference Room area

16. Recent Photographs of new premises– A Glimpse
QC –over all view & a
closer look of GC ,
HPLC / LCMS

17. Recent Photographs of new premises– A Glimpse
Lab Look from middle corridor
Kilo Lab under development
Generator for power Back up

18. Contact Info For Enquiries & Communications
Dr. Sreenivasa R. Mundla
Managing Director
Sreeni Labs Private Limited
Road No:12, Plot NO: 24,25 & 26
IDA, Nacharam
Hyderabad, 500 076; Telangana State
India,
e-mail: sreeni@sreenilabs.com
Info@sreenilabs.com
Ph: 011-91-98660 92626
THANKS
Dr. Sreenivasa R. Mundla
Managing Director
Sreeni Labs Private Limited
Road No:12, Plot NO: 24,25 & 26
IDA, Nacharam
Hyderabad, 500 076; Telangana State
India,
e-mail: sreeni@sreenilabs.com
Info@sreenilabs.com
Ph: 011-91-98660 92626
THANKS