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Holiday Discount 2011 -50% off!

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We announce our holiday discount! …

We announce our holiday discount!
www.genexplain.com

In the period between December 1st 2011 and January 15th 2012, we offer 50% off on the following products:

the geneXplain platform,
user-friendly, unified online access to a broad range of computational tools. Public domain, commercial or your own tools can be combined to workflows, and standard tasks have been implemented in pre-defined workflows;

IMC (In silico Molecular Cloning) and GT (Genome Traveler),
handling, interpreting and visualizing your high-throughput and next generation sequencing (NGS) data;

PASS (Prediction Activity Spectra for Substances) and PharmaExpert,
efficiently assess biological activities of organic drug-like compounds.

Get your free trial or demo versions now, try them, and order your licenses during the discount period!

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  • 1. Holiday discount, 50% off! December 1st 2011 - January 15th 2012We announce our holiday discount!In the period between December 1st 2011 and January 15th 2012 we offer 50% off onthe following products.Get your free trial or demo versions now, try them, and order your licenses during thediscount period!geneXplain PlatformThe geneXplain platform is an online toolbox and workflow management system for scientists in thefield of molecular biology. Here, you can store and analyze your experimental data - includingtranscriptomics, proteomics, and ChIP-Seq -, search for master regulator molecules, perform gene setenrichment analysis, and even add your own workflows and scripts.Key features of the platform:  Collection, storage and analysis of experimental data  Loading raw microarray data, BED files and more  Statistical processing of raw data  Comfortable work with tabulated data: comparison, joining, subtracting, sorting, etc.  Mapping to Gene Ontology terms, Gene Set Enrichment Analysis  Network clustering and search for master regulator molecules, visualization of pathway diagrams in several different layouts, export in a number of formats  Dynamic simulations  Browsing through several databases  Possibility to graphically program a specific pipeline (workflow), and add new scriptsThe geneXplain platform combines a growing number of analytical modules (bricks) under astandardized interface, which can be flexibly combined to comprehensive workflows via a simple drag-and-drop system. Predefined workflows are already available, as well as state-of-the-art bricks. Also,the scientific community is invited to add their own bricks as scripts or plug-ins into the platform.A fully functional free trial account, as well as further information, is available on our homepage:http://www.genexplain.com/genexplain-platform
  • 2. IMCIn-silico molecular cloning (IMC) is a renowned software package for comprehensive analysis,annotation and visualization of genomic features. It has been on the Japanese market for over sixyears and is now being distributed internationally.Key features of IMC:  Drawing of plasmid maps  DNA digestion by restriction enzymes  Ligation of sequences  PCR, from primer design to gel electrophoresis of the results  Amino acid profile analysis  Automatic or manual annotation of features  Search for homologies, patterns and repeats  Array analysisThe IMC software package provides a rich functionality; methods from in silico molecular cloning togenome to array analysis are included in the IMC Array edition (IMC-AE). The IMC Genomics edition(IMC-GE) focuses on functions to handle genome data, the standard edition (IMC-SE) provides all basicfunctions to visualize genomic annotation.The software runs on Windows, Mac and Linux and has been developed by in silico biology, Inc., inYokohama, Japan (http://www.insilicobiology.jp/en).A free fully functional trial version, as well as further information, is available on our homepage:http://www.genexplain.com/imc
  • 3. GenomeTravelerGenomeTraveler (GT) is a comprehensive software package for the analysis of whole genomes, whichsupports mapping of NGS fragments, mutation analysis, feature annotation and more.Key features of GenomeTraveler:  Mapping of single- and paired-end fragments  Contig mapping  de novo assembly  Import of mapping/assembling results from SAMtool, SOLiD, Velvet and Phrab  Profile peak detection  Mutation and SNP analysis  Expression analysis  The alignment viewer includes: search, annotation and comparative genome functionsGenomeTraveler is a program for next generation sequencing data analysis and annotation. It canhandle data from Roche/454 GS FLX, ABI SOLiD and Illumina GA, and provides a graphical interfacefor smooth viewing and editing of mapping and assembly results.The software runs on Windows, Mac and Linux and has been developed by in silico biology, Inc., inYokohama, Japan (http://www.insilicobiology.jp/en).A free fully functional trial version, as well as further information, is available on our homepage:http://www.genexplain.com/genome-traveler
  • 4. PASSThe acronym PASS stands for Prediction of Activity Spectra for Substances. After entering structuralformulas of drug-like organic compounds - either a single structure or a big library - the programinstantly gives a list of predicted bioactivities, accompanied by estimated mathematical probabilities.Key features of PASS:  Standard MOL and SDF files are used as input structural data  Multilevel Neighborhood of Atoms (MNA) descriptors are used to create robust and predictive SAR models  Activity spectra for thousands of compounds can be predicted within minutes  Impact of each atom on a particular activity is highlighted by its color  Currently, over 4,300 bioactivities can be predicted  Mathematical algorithm based on Bayesian estimates of probabilitiesPASS can quickly predict biological activity spectra for organic drug-like compounds qualitatively. Theactivities that can be predicted range from pharmacotherapeutic effects, biochemical mechanisms andtoxic and adverse effects to influence on the metabolism, gene regulation and transporter-relatedactivities. The software runs under Windows.Since more than 15 years, PASS is permanently being developed by Vladimir Poroikov, DmitryFilimonov & Associates currently working in the Department for Bioinformatics at the Institute ofBiomedical Chemistry, Russian Academy of Medical Sciences in Moscow(http://www.pharmaexpert.ru/PASSOnline/).A free demo version, as well as further information, is available on our website:http://www.genexplain.com/pass
  • 5. PharmaExpertPharmaExpert analyzes the relationships between biological activities, drug-drug interactions and themultiple targeting actions of chemical compounds. As a pharmacological knowledge-based tool, itprovides in silico screening of compounds using PASS prediction results.Key features of PharmaExpert:  Mechanism-effect relationship (MER) base, manually curated by experts, containing 11,049 mechanism-effect relationships  Selection of compounds with required therapeutic but without side effects  Comparative analysis of compounds with similar structures  Selection of compounds with multiple mechanisms of action  Analysis of drug-drug interactions with regard to their pharmacokinetic, pharmacodynamic and adverse effectsPharmaExpert uses PASS (Prediction of Activity Spectra for Substances) predictions as inputinformation. It provides a comfortable solution for data mining of the PASS prediction results to findthe best drug-like candidates from a set of compounds. The core of the program is a mechanism-effectrelationship (MER) base, which is used to determine cause-effect relationships for the compounds. LikePASS, the software runs under Windows.Since more than 15 years, PharmaExpert is permanently being developed by Vladimir Poroikov, DmitryFilimonov & Associates currently working in the Department for Bioinformatics at the Institute ofBiomedical Chemistry, Russian Academy of Medical Sciences in Moscow(http://www.pharmaexpert.ru/PASSOnline/).A free demo version, as well as further information, is available on our homepage:http://www.genexplain.com/pharmaexpert
  • 6. About geneXplain GmbHGeneXplain GmbH has been founded in April 2010 and is based in Wolfenbüttel, Germany. Thecompany aims at providing a comprehensive set of computational tools supporting the complete drugdevelopment pipeline from the statistical evaluation of high-throughput data, their biologicalinterpretation, and identification of potential targets to the prediction of most promising leadstructures. The geneXplain platform is based on BioUML and has been developed together with theInstitute of Systems Biology, Novosibirsk, Russia, where this leading-edge technology originates.Your geneXplain teamgeneXplain GmbHAm Exer 10bD-38302 WolfenbüttelGermanyphone: +49-5331-9450434e-mail: info@genexplain.comURL: http://www.genexplain.comFacebook: http://www.facebook.com/genexplainTwitter: https://twitter.com/#!/geneXplainLinkedIn: http://www.linkedin.com/company/genexplainGoogle+: https://plus.google.com/104816244332282237960