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Thyroid Carcinoma: Presentation, Diagnosis  & Management A Presentation by Augustin Brooks
Incidence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Everything to gain from diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
5 year survival of thyroid cancer  (England and Wales)
High risk patients ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
5-year age-standardised relative survival for thyroid cancer (England and Wales)
Risk factors for thyroid Ca ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Who to refer? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Urgent referrals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Examination ,[object Object],[object Object],[object Object],[object Object],[object Object]
Anaplastic carcinoma of the thyroid
Investigation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
U/S showing thyroid carcinoma
FNAC ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
FNA colloid goitre
Thy Classification Classification Histology Action Thy 1 Non-diagnostic Repeat FNAC (Unless cyst aspirated to dryness) Thy 2 Non-neoplastic Two non-neoplastic results 3-6/12 apart advised Thy 3 (i) Follicular lesion / suspected neoplasm Some cases will be hyperplastic nodules Surgical removal of the lobe. Completion thyroidectomy may be necessary if histology malignant Thy 3 (ii) Worrying features but cells too scanty to qualify for Thy 4  Discuss in MDT Repeat FNAC advised Thy 4 Suspicious of malignancy  but not diagnostic Surgical intervention advised Thy 5 Diagnostic of malignancy Surgical intervention Consider radioT, chemoT
Papillary carcinoma
Prognostic scoring systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TNM classification of thyroid Ca ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Papillary or Follicular Ca staging < 45 years > 45 years Stage I Any T, N & M0 pT1, N0, M0 Stage II Any T, N & M1 pT2, N0, M0 pT3, N0, M0 Stage III pT4, N0, M0 Any pT, N1, M0 Stage IV Any pT, N, M1 Undifferentiated or anaplastic carcinomas are ALL stage IV
10 year mortality rate for DTC Stage 10 yr mortality (%) I 1.7 II 15.8 III 30 IV 60.9
Pre-op ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Surgical Terms ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Risks of surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Papillary carcinoma surgery ,[object Object],[object Object],[object Object],[object Object],[object Object]
Follicular carcinoma surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anaplastic thyroid Ca ,[object Object],[object Object],[object Object],[object Object]
Lymphoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lymph node surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Early post-surgical Mx ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Post-op  131 I ablation?  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Side effects of post-op  131 I ablation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radioiodine ablation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
131 I diagnostic scans after  131 I ablation ,[object Object],[object Object],[object Object],[object Object]
Papillary carcinoma of thyroid.  Iodine uptake scan showing residual thyroid tissue
Is a repeat  131 I diagnostic scan ever required? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
External beam radiotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Post-Tx F/U ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Thyroglobulin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tg measurement ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Long-term follow-up ,[object Object],[object Object],[object Object],[object Object],[object Object]
Any questions?

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Thyroid Carcinoma Presentation

  • 1. Thyroid Carcinoma: Presentation, Diagnosis & Management A Presentation by Augustin Brooks
  • 2.
  • 3.  
  • 4.
  • 5. 5 year survival of thyroid cancer (England and Wales)
  • 6.
  • 7. 5-year age-standardised relative survival for thyroid cancer (England and Wales)
  • 8.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. Anaplastic carcinoma of the thyroid
  • 14.
  • 15. U/S showing thyroid carcinoma
  • 16.
  • 18. Thy Classification Classification Histology Action Thy 1 Non-diagnostic Repeat FNAC (Unless cyst aspirated to dryness) Thy 2 Non-neoplastic Two non-neoplastic results 3-6/12 apart advised Thy 3 (i) Follicular lesion / suspected neoplasm Some cases will be hyperplastic nodules Surgical removal of the lobe. Completion thyroidectomy may be necessary if histology malignant Thy 3 (ii) Worrying features but cells too scanty to qualify for Thy 4 Discuss in MDT Repeat FNAC advised Thy 4 Suspicious of malignancy but not diagnostic Surgical intervention advised Thy 5 Diagnostic of malignancy Surgical intervention Consider radioT, chemoT
  • 20.
  • 21.
  • 22. Papillary or Follicular Ca staging < 45 years > 45 years Stage I Any T, N & M0 pT1, N0, M0 Stage II Any T, N & M1 pT2, N0, M0 pT3, N0, M0 Stage III pT4, N0, M0 Any pT, N1, M0 Stage IV Any pT, N, M1 Undifferentiated or anaplastic carcinomas are ALL stage IV
  • 23. 10 year mortality rate for DTC Stage 10 yr mortality (%) I 1.7 II 15.8 III 30 IV 60.9
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 35.
  • 36.
  • 37.
  • 38. Papillary carcinoma of thyroid. Iodine uptake scan showing residual thyroid tissue
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.
  • 44.