A nicotine jab to help kick the butt

1. A nicotine jab to
help kick the butt

2. Contd..
Scientists have designed a new effective nicotine vaccine which, they
believe, could help smokers and even drug addicts quit.The body
reacts to the vaccine by creating antibodies to bind specifically to
nicotine molecules. When a person later uses tobacco, the anti-
nicotine antibodies stop the nicotine molecules from entering the
central nervous system.
The problem with the previous nicotine vaccine, which only worked in
30% of patients, was that it did not single out the most common form of
nicotine for attack.

3. Contd..
Nicotine has two forms that look like mirror images -a “right-handed“
version and a “left-handed“ one. Even though 99% of the nicotine in
tobacco is the left-handed version, the previous vaccine elicited
antibodies against both.
Researchers have now elicited a more robust antibody response by
creating a vaccine from only left-handed nicotine haptens.
Compared with the righthanded hapten vaccine, the left-handed
hapten vaccine prompted the body to create four times as many
antibodies. The 50-50 mix was only 60% as effective as the pure left-
handed version.

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