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Drug testing on `heart on-a-chip' gets a step closer
1. Drug testing on `heart-on-a-
chip' gets a step closer
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2. Contd..
Researchers, including one of Indian origin, have created a
`heart-on-a-chip' loaded with human cardiac muscle cells
that mimic the real organ to serve as a novel tool to
screen medicines. Researchers developed a network of
pulsating cardiac muscle cells housed in an inch-long
silicone device that effectively models human heart tissue,
and they have demonstrated the viability of this system as
a drug-screening tool by testing it with cardiovascular
medications.
This organ-on-a-chip represents a major step forward in
the development of accurate, faster methods of testing
for drug toxicity , researchers said. “Ultimately , these
chips could replace the use of animals to screen drugs for
safety and efficacy ,“ said professor Kevin Healy from the
University of California, Berkeley .
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3. Contd..
The authors noted a high failure rate associated with the
use of non-human animal models to predict human
reactions to new drugs.
“It takes about £5 billion on average to develop a drug,
and 60% of that figure comes from upfront costs in the
research and development phase. Using a well-designed
model of a human organ could significantly cut the cost
and time of bringing a new drug to market,“ said Healy .
The heart cells were derived from human-induced
pluripotent stem cells, the adult stem cells that can be
coaxed to become many different types of tissue.
Researchers designed their heart-on-a-chip so that its 3D
structure would be comparable to the geometry and
spacing of connective tissue fibre in a human heart.
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