CDD  aids  C ollaborations Result New leads reveal known drugs that reverse chloroquine resistance
Yes We Can! © 2010 Collaborative Drug Discovery, Inc.
CDD Successfully Builds  Collaborative Drug Discovery Communities <ul><ul><li>DDT, 2009 (14: 261-270):   </li></ul></ul><u...
CDD Platform <ul><li>Modules:   </li></ul><ul><ul><li>CDD Vault  – Secure place for private data – private by default </li...
CDD Database for Your Private Data Copyright   © 2010 All Rights Reserved Collaborative Drug   Discovery
Collaborate Mode 1 – Big Pharma   with single login to multiple CROs/Biotech groups Copyright   © 2010 All Rights Reserved...
Collaborate Mode 2 – Peer-to-Peer:  Any  Data via Any Query Can Be Securely Shared CDD DB group 1 CDD DB group 2 CDD DB gr...
New Types of Offerings for a Rapidly Changing Industry <ul><li>CDD Community:  tap into global R&D via “crowd-sourcing” </...
Acknowledgements Copyright   © 2010 All Rights Reserved Collaborative Drug   Discovery <ul><li>Sean Ekins, PhD, DSc  (Coll...
<ul><li>Start with Strong Mission & Values </li></ul><ul><ul><ul><li>Neglected disease and commercial disease are both cor...
CDD   Collaborative Drug Discovery, Inc. Burlingame, CA www.collaborativedrug.com  Barry A. Bunin, PhD CEO & President  [e...
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Barry bunin open science summit at the berkeley intl house 2010

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  • CDD Experienced Team Innovates and Executes Barry Bunin, PhD (Pres. &amp; Cofounder as first Eli Lilly EIR) Libraria (CEO, Pres.-CSO), Arris Pharmaceuticals (Sr. Scientist), Genentech, UC Berkeley (Ellman), Columbia University, author. Moses Hohman, PhD (Director Software Engineering) Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard ( magna cum laude, Physics) Sylvia Ernst, PhD (Director Community Growth &amp; Sales) Left 800-lb Gorillas: Accelrys-Scitegic, MDL-Elsevier-Beilstein Peter Cohan (BOD &amp; Overall Sales Strategy) Symyx (VP Bus Dev &amp; President-Discovery Tools), MDL (VP Customer Marketing), www.secondderivative.com, author. Omidyar Network, Founders Fund, &amp; Lilly (BOD observers) WSGR (Corporate Counsel), Rina Accountancy (GAAP compliance) Partners: Hub Consortium Members, ChemAxon, DNDi, MMV, Sandler Center… CDD SAB: Christopher Lipinski PhD, James McKerrow, MD PhD, David Roos PhD, Adam Renslo PhD, Wes Van Voorhis, MD PhD
  • CDD Experienced Team Innovates and Executes Barry Bunin, PhD (Pres. &amp; Cofounder as first Eli Lilly EIR) Libraria (CEO, Pres.-CSO), Arris Pharmaceuticals (Sr. Scientist), Genentech, UC Berkeley (Ellman), Columbia University, author. Moses Hohman, PhD (Director Software Engineering) Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard ( magna cum laude, Physics) Sylvia Ernst, PhD (Director Community Growth &amp; Sales) Left 800-lb Gorillas: Accelrys-Scitegic, MDL-Elsevier-Beilstein Peter Cohan (BOD &amp; Overall Sales Strategy) Symyx (VP Bus Dev &amp; President-Discovery Tools), MDL (VP Customer Marketing), www.secondderivative.com, author. Omidyar Network, Founders Fund, &amp; Lilly (BOD observers) WSGR (Corporate Counsel), Rina Accountancy (GAAP compliance) Partners: Hub Consortium Members, ChemAxon, DNDi, MMV, Sandler Center… CDD SAB: Christopher Lipinski PhD, James McKerrow, MD PhD, David Roos PhD, Adam Renslo PhD, Wes Van Voorhis, MD PhD
  • Barry bunin open science summit at the berkeley intl house 2010

    1. 1. CDD aids C ollaborations Result New leads reveal known drugs that reverse chloroquine resistance
    2. 2. Yes We Can! © 2010 Collaborative Drug Discovery, Inc.
    3. 3. CDD Successfully Builds Collaborative Drug Discovery Communities <ul><ul><li>DDT, 2009 (14: 261-270): </li></ul></ul><ul><ul><li>$1.89M Tuberculosis B&MGF Project </li></ul></ul><ul><ul><li>>5 Years CDD SaaS in the Cloud </li></ul></ul><ul><ul><li>Thousands of scientists engaged: </li></ul></ul>
    4. 4. CDD Platform <ul><li>Modules: </li></ul><ul><ul><li>CDD Vault – Secure place for private data – private by default </li></ul></ul><ul><ul><li>CDD Collaborate – Selectively share subsets of data </li></ul></ul><ul><li>Datasets: </li></ul><ul><ul><li>CDD Public – expanding public data sets </li></ul></ul><ul><ul><ul><li>published compounds </li></ul></ul></ul><ul><ul><ul><li>data from community members </li></ul></ul></ul><ul><ul><ul><li>vendor libraries </li></ul></ul></ul><ul><ul><li>Unique to CDD – simultaneously query your private data, collaborators’ data, & public data </li></ul></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
    5. 5. CDD Database for Your Private Data Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
    6. 6. Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
    7. 7. Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared CDD DB group 1 CDD DB group 2 CDD DB group 3 CDD DB group 4 Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
    8. 8. New Types of Offerings for a Rapidly Changing Industry <ul><li>CDD Community: tap into global R&D via “crowd-sourcing” </li></ul><ul><li>CDD Alliance: better management of your collaborations </li></ul><ul><li>CDD Customize: fast, good, and cost-effective = agile </li></ul>Use CDD Vault™, Collaborate™, Public™ for Global R&D Community
    9. 9. Acknowledgements Copyright © 2010 All Rights Reserved Collaborative Drug Discovery <ul><li>Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia Office) </li></ul><ul><ul><li>Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo </li></ul></ul><ul><li>Moses Hohman, PhD (VP Software Development) </li></ul><ul><ul><li>Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard ( magna cum laude, Physics) </li></ul></ul><ul><li>Sylvia Ernst, PhD (Senior Director Community Growth – Northwest Office) </li></ul><ul><ul><li>Accelrys-Scitegic, MDL </li></ul></ul><ul><li>Andrea Barry (Senior Director Business Dev – N. Carolina Office) </li></ul><ul><ul><li>Accelrys-Scitegic, MDL </li></ul></ul><ul><li>Kellan Gregory (Head Community Interests Group ) </li></ul><ul><ul><li>Anna Spektor (Community Advocate, ex-IDBS) </li></ul></ul><ul><li>Eli Lilly & Co. </li></ul><ul><li>Bill & Melinda Gates Foundation </li></ul><ul><ul><li>Initial TB pilot laboratories </li></ul></ul><ul><li>CDD Researcher Community </li></ul><ul><ul><li>1000s of CDD collaborators from academia, foundations and industry </li></ul></ul><ul><ul><li>ChemAxon Tools (under the hood) </li></ul></ul>
    10. 10. <ul><li>Start with Strong Mission & Values </li></ul><ul><ul><ul><li>Neglected disease and commercial disease are both core components </li></ul></ul></ul><ul><ul><ul><li>Collaborative culture – share successes and failures, as much as possible </li></ul></ul></ul><ul><ul><ul><li>Tap leading community expertise with industry focused process </li></ul></ul></ul><ul><li>Do Groundbreaking Work </li></ul><ul><ul><ul><li>Revolutionary approaches to solving critical health problems </li></ul></ul></ul><ul><ul><ul><li>Imagine what would be possible in an ideal world, practically implement </li></ul></ul></ul><ul><ul><ul><li>Discover drugs while changing the nature of the game </li></ul></ul></ul><ul><ul><ul><li>What if…you had a magic wand? </li></ul></ul></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Answers for Our Field
    11. 11. CDD Collaborative Drug Discovery, Inc. Burlingame, CA www.collaborativedrug.com Barry A. Bunin, PhD CEO & President [email_address] Archive, Mine, Collaborate ®
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