This document summarizes information about a video arthroscopy unit at a Peruvian hospital. It lists the doctors and staff in the unit. It also provides data on platelet concentration from blood, comparing the platelet yield and concentration increases achieved by different platelet concentration products approved by the FDA. The document indicates that the FDA approves products that can achieve a platelet concentration increase of at least 400% over baseline peripheral blood concentration.

1. HOSPITAL NACIONAL GUILLERMO ALMENARA IRIGOYEN ESSALUD DEPARTAMENTO DE ORTOPEDIA, TRAUMATOLOGÍA Y CIRUGÍA DE MANO Y MIEMBRO SUPERIOR UNIDAD DE VIDEO ARTROSCOPÍA Dr. GASTON BARNECHEA Dr. GUILLERMO OCHOA Dr. OSCAR SOSA Dr. SIXTO MEZA

2. UNIDAD DE VIDEO ARTROSCOPIA HOSPITAL NACIONAL GUILLERMO ALMENARA IRIGOYEN EsSALUD LIMA PERU Dr. Sosa Dr. Meza Dr. Ochoa Dr. Barnechea Dr. Noriega Anestesiólogo Bloqueos Lic. María Rivera Lic. Semiramis Rojas

18. Concentración Plaquetaria en sangre 200,000 Plaquetas 1 µL 60 cc 12000`ooo,ooo plaq 10 cc 2000`ooo,ooo plaq 10 cc 10 cc 10 cc 6 cc 1‘000,000 a 1 ‘200,000 plaq/µL 300,000plaq/µL

26. S. V. Kevy, MD; M. S. Jacobson, PhD; R. J. Mandle*, PhD Children’s Hospital, Harvard Medical School, The CBR Institute for Biomedical Research * Bioscience Research Associates, Boston, MA

27. POR QUE CONCENTRAR? PLAQUETAS EN SANGRE PERIFERICA PLAQUETAS EN CONCENTRADO

28. Data from CBR Institute Biomedical Research, Boston, MA Presented at AMSECT 2004 COMPARACION DE LOS PRODUCTOS PARA CONCENTRACION DE PLAQUETAS EN EL MERCADO FDA APRUEBA COMO EFICIENTE LA CONCENTRACION DE ≥400% SOBRE LA BASE DE LA CONCENTRACION EN SANGRE PERIFERICA Anticoagulated Blood Processed (ml) Baseline Platelet count X10 3 /µl Platelet Concentrate Vol-ml Platelet Concentrate Count X10 3 /µl Platelet Yield % CV % Platelet Increase over Baseline SmartPReP ® 2 60 ml n=23 228 ± 29 10 ± 0.16 1033 ± 164 75.9 ± 4.9 6.4 4.5 ± 0.2 SmartPReP ® 2 60 ml n=4 221 ± 21 7 ± 0.3 1675 ± 88 86.8 ± 3.4 4.0 7.6 ± 0.3 (in7ml) Biomet GPS TM 60 ml n=6 192 ± 48 5.5 ± 0.2 809 ± 396 42.6 ± 9.0 21 4.1 ± 0.8 (in5.5ml) MAGELLAN TM 60 ml n=14 224 ± 26.4 10 ± 0.1 818 ± 168 60.9 ± 5.5 9.0 3.5 ± 0.3 CASCADE 10 ML n=6 232± 41.4 5.0± 1.0 246 ± 51.3 57.9 ± 11.9 20.5 1.06 ± 0.1

57. ANESTESIA

95. UNIDAD DE VIDEO ARTROSCOPIA HOSPITAL NACIONAL GUILLERMO ALMENARA IRIGOYEN EsSALUD LIMA PERU