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Psychiatric Emergencies
Only 4 reasons for admitting Psychiatric patient
1. Harm to self (suicidal)
--> stabilize medically/ surgically first
2. Harm to others (homicidal)
3. Refuses psych medications
• No longer such an emergency because of orodispersible/
dissolving tablets
4. Social emergency (incest, war, postpartum psychosis)
Suicide Assessment
• Planning depth
• Alone or with others
• Lethality
• Support system available
How to help a friend
• Ask about it
• Give options for help
• Seek support for your friend and for yourself
• Remember: you’re not responsible for ending the self-abuse.
Just continue to be a good friend.
Behavioral Predictors of violence
• Angry words
• Loud language
• Abuse language
• Physical agitation such as
making fists, pacing and
restlessness
How to de-escalate a patient
• Use a calm voice
• Sit down with the patient
• Maintain adequate physical distance of at 2 arms length
• Attempt to establish rapport
• Listen to the patients’ concerns
Teach Anger Management skills
• Deep breathing exercises – release serotonins
• Pray – prefrontal cortex
• Alternate solutions – mind over instinct
• Walk away – prefrontal cortex
Social Emergencies
• Rape
• Incest
• War
• Abuse
– Child abuse (RA 7610) vs Adult abuse (RA 9262)
“Violence”
1. Physical
2. Sexual
3. Psychological
4. Economic – adult
5. Neglect – child
RA9262
Anti-violence Against
Women And Their Children
Act Of 2004
Physical Violence
• refers to acts that include
– bodily or physical harm
Sexual violence
• refers to an act which is sexual in nature, committed
against a woman or her child:
– rape, sexual harassment, acts of lasciviousness, treating a
woman or her child as a sex object, making demeaning and
sexually suggestive remarks, physically attacking the sexual
parts of the victim’s body, forcing her/him to watch
obscene publications and indecent shows or forcing the
woman or her child to do indecent acts and/or make films
thereof, forcing the wife and mistress/lover to live in the
conjugal home or sleep together in the same room with
the abuser;
– acts causing or attempting to cause the victim to engage in
any sexual activity by force, threat of force, physical or
other harm or threat of physical or other harm or coercion;
– Prostituting the woman or child.
Psychological violence
• refers to acts or omissions causing or likely to cause mental or
emotional suffering of the victim:
– intimidation, harassment, stalking, damage to property, public
ridicule or humiliation, repeated verbal abuse and mental infidelity.
– causing or allowing the victim to witness the physical, sexual or
psychological abuse of a member of the family to which the victim
belongs, or to witness pornography in any form or to witness abusive
injury to pets or to unlawful or unwanted deprivation of the right to
custody and/or visitation of common children.
Economic abuse
• refers to acts that make or attempt to make a
woman financially dependent :
• withdrawal of financial support or preventing the victim
from engaging in any legitimate profession, occupation,
business or activity, except in cases wherein the other
spouse/partner objects on valid, serious and moral grounds
as defined in Article 73 of the Family Code;
• deprivation or threat of deprivation of financial resources
and the right to the use and enjoyment of the conjugal,
community or property owned in common;
• destroying household property;
• controlling the victims’ own money or properties or solely
controlling the conjugal money or properties.
Battered Woman Syndrome
• refers to a pattern of psychological and behavioral symptoms
found in women living in battering relationships as a result of
cumulative abuse
It is better to live alone in the desert than
with an ill-tempered spouse.
Proverbs 21: 19
Psychiatric Management Modalities
Biological Therapies
Psychological Therapy
Social Therapy
Biological Therapies
1. Psychopharmacology
2. ECT
3. Detoxification
4. Psychosurgery
5. Light therapy
6. Sleep deprivation
7. Acupuncture/Acupressure – adj
8. Endocrinological – limited CA
9. Coma therapy – dangerous!!!
Neurotransmitters to regulate
1. Biogenic amines – synth in axon term
– Dopamine
– Norepinephrine MAO
– Serotonin = 5-HydroxyTryptamine
2. Amino acids – use 2nd messengers
– GABA (-)
– Glutamate (+)
Psychosis
• Dopamine dysequilibrium
– Mesolimbic – over  positive Sx
– Mesocortical – hypo  negative Sx
• Decreased NorEpinephrine
– Poor concentration
– Lack of motivation
• Serotonin imbalance
– irritability, anxiety, depression,
mania
• Depletion of glutamate
– delusion
– auditory hallucination
– conceptual disorganization
– negative Sx
• Decreased GABA
– Insomnia
Mood Disorders
• Etiology
–Genetic
–Psychodynamic
• Pathology
–Decreased serotonin
– Decreased Dopamine
 Drop in norepinephrine
Anxiety is part of body’s normal survival instinct
Palpitations
Sweating
Trembling
Shaking
Shortness of breath
Choking
Loss/increased appetite
Chest pain
Nausea/vomiting
Fear of loosing control
Numbness
Loss of sleep
Social withdrawal
Irritable
hypothalamus
pituitary
cortisol
Fight or flight (ANS)
ACTH
Adrenal cortex
NE
Ach
Psychopharmacology
• Antipsychotics
• Antidepressants
• Mood Stabilizers
• Sedatives/Hypnotics
• (Psychostimulants)
Special Population
• Start low, go slow!
• Children – ½ dose
• Elderly – ½ dose
• Pregnant – avoid
• Kidney, liver – ½ dose
Side effects
• Dopamine blockade
– Endocrine dysfxn
• Hyperprolactinemia
• Menstrual dysfxn
• Sexual dysfxn
– Movement d/o
• Akathisia
• Dystonia
• Parkinsonism
• Tardive dyskinesia
Side effects
• Antiadrenergic (α1) - NE
– Dizziness
– Postural hypotension
– Reflex tachycardia
Side effects
• Antihistaminergic
– Hypotension
– Sedation
– Weight gain
Side effects
• Muscarinic blockade (Ach)
– Red as a beet - drowsiness
– Dry as a bone – constipation, urinary retention, dry mouth
– Blind as a bat – blurred vision
– Mad as a hatter – incl sz, drowsiness
Side effects
• Serotonin
– Mania
– Depression
Serotonin syndrome
• Rapid onset of symptoms
• 60% present within 6 hours after initial use of medication, an
overdose, or a change in dosing
• Mental status changes: confusion, restlessness, agitation, anxiety,
decreased level of consciousness
• Neuromuscular abnormalities: tremor, rigidity, clonus, myoclonus,
hyperreflexia, ataxia
• Autonomic hyperactivity : diaphoresis, hyperthermia, shivering,
mydriasis, nausea, diarrhea
• Vital signs: tachycardia, labile BP changes
Treatment SS
• Discontinuation of all serotonergic agents
• Supportive care, many do not require tx
• Consult with a medical toxicologist, clinical
pharmacologist, or poison control center
• Cyproheptadine (serotonin antagonist)
• Intubation and ventilation : severe SS with
hyperthermia (a temp.> 41.1°C)
Other side effects
• Blood dyscrasias (agranulocytosis)
• Allergic reactions
• Anorexia
• Cardiac conduction abnormalities
• Nausea
• Vomiting
• Seizures
Antipsychotics
Typical/Conventional
Phenothiazine
Aliphatic
Chlorpromazine
Piperidine
Thioridazine
Piperazine
Fluphenazine
Perphenazine
Trifluoperazine
Butyrophenone
Haloperidol
Atypica/Novel
Dibenzodiazepine
Clozapine
Benzisoxazole
Risperidone Olanzapine
Ziprasidone Quetiapine
Additional arms
• Risperidone - α
• Quetiapine – M1, H1, α
• Olanzapine – D1, D3, D4, M1, H1, α
• Ziprasidone - ?
EPS treatment
• Be ready to give O2 if breathing problems develop.
• PO, IM or IV diphenhydramine (Benadryl) 50mg q 4-5 hrs. IV form acts
very quickly so great to use if pt has IV access already. If not may need
to use IM. IM takes about 30 minutes to improve sx and po takes
around 60 minutes.
• Benztropine (Cogentin) 1-2mg PO or IM q 8-12 hours.
Breastfeeding
• Typicals  reports of toxicity/developmental delays
• Atypicals - ORQA
Risperidone
Olanzapine
No toxicity in case reports
Quetiapine No neurodevelopment delays in children followed up to 3
years; low transfer
Clozapine High accumulation in breast milk; report of infant seizure
Aripiprazole Milk: plasma ratio same as other atypicals
Ziprasadone No adverse effects reported
2014 APA Presentations
Pregnant – placental transfer
• No congenital malformations- ORQC
– Olanzapine
– Risperidone
– Quetiapine
– Clozapine
• Atypical antipsychotics : may cause short-term delay of
cognitive, motor, social-emotional, and adaptive behavior
development
2014 APA Presentations
Antidepressants
Venlafaxine
Risk of
psychosis
SNRI
• Venlafaxine (Effexor)
• Desvenlafaxine (Pristiq)
• Duloxetine (Cymbalta)
NaSSA
• Noradrenergic and Specific Serotonergic Antidepressant
• Mirtazapine
• Blocks α2  inc NE
• 5HT2 and 5HT3 blocker  inc serotonin
SSRI
• Selective Serotonin Reuptake Inhibitor
– Fluoxetine (Prozac)
– Fluvoxamine (Faverin)
– Sertraline (Zoloft)
– Citalupram (Lupram)
– Escitalupram (Lexapro)
– Paroxetine (Paxil, Seroxat)
SSRI side effect
• Sexual dysfunction
• Headache
• Nervousness
• Insomnia
• Anxiety
• Tremor
• Drowsiness
Mood Stabilizers
Mood Stabilizers
• Regulate norepinephrine
• Regulate dopamine
• Regulate serotonin
• Increase GABAB receptors in hippocampus
Table on Medications for Bipolar Disorders
Acute
Phase
Mantena
nce
Phase
Rapid
Cycling
Co-morbid
Substance
Abuse
Advantages
Lithium
 
Valproate
   
Lesser laboratory
monitoring;
Rapid response (3d);
IV preparation available
Carbamazepine
Oxcarbamazepine   
Antipsychotics

Lithium
• 1st line
• Advantages:
– Safest with Liver Dx
• Narrow therapeutic window
– 0.9-1.4 mmol/Li (Serum)
Lithium
• Side effects:
– Polyuria
– polydypsia
– weight gain
– cognitive problems
– impaired coordination
– Acne
– hair loss
– slurred speech
– Hypothyroidism
– fine hand tremor
– Confusion
– severe GI effects
Carbamazepine
Oxcarbamazepine
• Effective specially for early onset
• Side effects:
– Stevens Johnson
– Constipation
– dry mouth
– Nausea
– Dizziness
– Sedation
– Headache
– decreased WBC
Valproate
• Advantages:
– IV preparation available
– Wide therapeutic window
• Side effects:
– anorexia
– gastrointestinal distress (min Depakote)
– Tremor
– Sedation
– risk for hepatotoxicity
Problem Areas
Elderly CVD Kidney Liver DM Pregnant Breast-
feeding
Lithium M M H L L M H
Valproate M L H H M H L
Carbamazepine L M M L L M L
Oxcarbamazepine L M H M L M L
Anxiolytics
Anxiolytics
1. Benzodiazepines (BZD)
a. Short acting
• Alprazolam, bromazepam, lorazepam, oxazepam
b. Long acting
• Clonazepam, diazepam, clorazepate
2. ß blockers
– Propanolol, oxprenolol
3. Buspirone
Other Anti-anxiety agents
1. SSRI
2. SNRI
3. NaSSA
Adverse effects of BZD
1. CNS depression
– drowsiness, excessive sedation, impaired motor coordination,
confusion,& memory loss
2. Paradoxical reactions
– excitement, stimulation,& hyperactivity
3. Amnesia
4. can affect the GIT
5. can produce allergic reaction
Drug Interaction
• BZD enhance effects of
– alcohol, barbiturates, phenothiazines, opioids
• increase in the effects of BZD
– Inhibitors of oxidative metabolism
• ascimitidine, disulfiram, isoniazid & omperazole
ECT Theories
• All–or-nothing Sz (not all parts same)
• Generalized central Sz spreads through cortex
• Postictal suppression = 90 sec
• High-voltage delta and theta waves = “aftershock”
• Inc cerebral blood flow
• Inc permeability of blood-brain barrier
Patient preparation
• NPO 6hrs prior
• Mouth check
• IV
• Bite block
• O2 5 li/min
• Emergency ABC kit
ECT
• Placement : Frontotemporal
– Bilateral
– Unilateral (right)
• Sz threshold higher
– for men and elderly
– Inc head size
• Use 50% Sz threshold bilateral; 100% unilateral = 25-150 sec Sz
• Overdose – TID, Sz 3 hrs
Contraindications
1. SOL
2. High ICP
3. Intracerebral bleed (1 month PTA min)
4. Recent MI (3 months PTA min)
5. Retinal detachment
6. Pheochromocytoma
7. High anesthesia risk
Drug Rehabilitation
Psychotherapy
Psychotherapy on the Brain
•Normalization of synaptic and metabolic
activity in the limbic and prefrontal regions
•increased binding to 5HT1A receptors
- Barsaglini et al (2013) Journal of Psychoneurobiology
- Collerton (2013) Frontiers in Psychology
- Karlsson (2011) Psychiatric TImes
Types of Psychotherapy
1. Psychoanalysis – Ego psychology
2. Psychoanalytic Psychotherapy – object relations
3. Behavioral Therapy - Skinner
4. Cognitive Psychotherapy – Beck
5. Cognitive Behavioral Psychotherapy – combination
6. Supportive Psychotherapy
7. Group Therapy
8. Family Therapy
9. Play Therapy
Basic rules
• Sit at eye level
• Sit at arm’s length to 2 arm’s length away
• Do not cross your arms
• Dress appropriately
• Do not touch patient
• Allow to cry, do not touch when crying
• Religion and Psychiatry do not mix
Psychoanalysis
Psychoanalytic Psychotherapy
Psychoanalysis
• Id-ego-superego
• Defense mechanisms
• Px = analysand
• Therapist = analyst
Tasks of analyst
• Help patient gain insight so unconscious becomes
conscious
– Self-knowledge
• Techniques
– Neutrality
– Confrontation
– Interpretation
– Reconstruction
• Transference neurosis
Play Therapy
You can discover more about a person in an hour
of play than in a year of conversation.
- Plato
Why Play Therapy
• Children may not be able to verbalize specially with trauma
• Toys act as words for children
• Play act as language for children
Play Therapy Goals
• Explore and express feelings
• Restore/ boost self-acceptance, self-confidence, self-reliance
• Encourage ability to make good decisions
Rules
• Do not reprimand
• No right or wrong
• Do not require/ force
• Child has a right to remain silent
• Growth cannot be rushed
• Therapist must be playful and fun-loving
• Therapist must be self-confident and self-reliant

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III-psych-emergencies-management.pptx

  • 2. Only 4 reasons for admitting Psychiatric patient 1. Harm to self (suicidal) --> stabilize medically/ surgically first 2. Harm to others (homicidal) 3. Refuses psych medications • No longer such an emergency because of orodispersible/ dissolving tablets 4. Social emergency (incest, war, postpartum psychosis)
  • 3. Suicide Assessment • Planning depth • Alone or with others • Lethality • Support system available
  • 4. How to help a friend • Ask about it • Give options for help • Seek support for your friend and for yourself • Remember: you’re not responsible for ending the self-abuse. Just continue to be a good friend.
  • 5. Behavioral Predictors of violence • Angry words • Loud language • Abuse language • Physical agitation such as making fists, pacing and restlessness
  • 6. How to de-escalate a patient • Use a calm voice • Sit down with the patient • Maintain adequate physical distance of at 2 arms length • Attempt to establish rapport • Listen to the patients’ concerns
  • 7. Teach Anger Management skills • Deep breathing exercises – release serotonins • Pray – prefrontal cortex • Alternate solutions – mind over instinct • Walk away – prefrontal cortex
  • 8. Social Emergencies • Rape • Incest • War • Abuse – Child abuse (RA 7610) vs Adult abuse (RA 9262)
  • 9. “Violence” 1. Physical 2. Sexual 3. Psychological 4. Economic – adult 5. Neglect – child
  • 10. RA9262 Anti-violence Against Women And Their Children Act Of 2004
  • 11. Physical Violence • refers to acts that include – bodily or physical harm
  • 12. Sexual violence • refers to an act which is sexual in nature, committed against a woman or her child: – rape, sexual harassment, acts of lasciviousness, treating a woman or her child as a sex object, making demeaning and sexually suggestive remarks, physically attacking the sexual parts of the victim’s body, forcing her/him to watch obscene publications and indecent shows or forcing the woman or her child to do indecent acts and/or make films thereof, forcing the wife and mistress/lover to live in the conjugal home or sleep together in the same room with the abuser; – acts causing or attempting to cause the victim to engage in any sexual activity by force, threat of force, physical or other harm or threat of physical or other harm or coercion; – Prostituting the woman or child.
  • 13. Psychological violence • refers to acts or omissions causing or likely to cause mental or emotional suffering of the victim: – intimidation, harassment, stalking, damage to property, public ridicule or humiliation, repeated verbal abuse and mental infidelity. – causing or allowing the victim to witness the physical, sexual or psychological abuse of a member of the family to which the victim belongs, or to witness pornography in any form or to witness abusive injury to pets or to unlawful or unwanted deprivation of the right to custody and/or visitation of common children.
  • 14. Economic abuse • refers to acts that make or attempt to make a woman financially dependent : • withdrawal of financial support or preventing the victim from engaging in any legitimate profession, occupation, business or activity, except in cases wherein the other spouse/partner objects on valid, serious and moral grounds as defined in Article 73 of the Family Code; • deprivation or threat of deprivation of financial resources and the right to the use and enjoyment of the conjugal, community or property owned in common; • destroying household property; • controlling the victims’ own money or properties or solely controlling the conjugal money or properties.
  • 15. Battered Woman Syndrome • refers to a pattern of psychological and behavioral symptoms found in women living in battering relationships as a result of cumulative abuse
  • 16. It is better to live alone in the desert than with an ill-tempered spouse. Proverbs 21: 19
  • 19. Biological Therapies 1. Psychopharmacology 2. ECT 3. Detoxification 4. Psychosurgery 5. Light therapy 6. Sleep deprivation 7. Acupuncture/Acupressure – adj 8. Endocrinological – limited CA 9. Coma therapy – dangerous!!!
  • 20. Neurotransmitters to regulate 1. Biogenic amines – synth in axon term – Dopamine – Norepinephrine MAO – Serotonin = 5-HydroxyTryptamine 2. Amino acids – use 2nd messengers – GABA (-) – Glutamate (+)
  • 21. Psychosis • Dopamine dysequilibrium – Mesolimbic – over  positive Sx – Mesocortical – hypo  negative Sx • Decreased NorEpinephrine – Poor concentration – Lack of motivation • Serotonin imbalance – irritability, anxiety, depression, mania • Depletion of glutamate – delusion – auditory hallucination – conceptual disorganization – negative Sx • Decreased GABA – Insomnia
  • 22. Mood Disorders • Etiology –Genetic –Psychodynamic • Pathology –Decreased serotonin – Decreased Dopamine  Drop in norepinephrine
  • 23. Anxiety is part of body’s normal survival instinct Palpitations Sweating Trembling Shaking Shortness of breath Choking Loss/increased appetite Chest pain Nausea/vomiting Fear of loosing control Numbness Loss of sleep Social withdrawal Irritable hypothalamus pituitary cortisol Fight or flight (ANS) ACTH Adrenal cortex NE Ach
  • 24. Psychopharmacology • Antipsychotics • Antidepressants • Mood Stabilizers • Sedatives/Hypnotics • (Psychostimulants)
  • 25. Special Population • Start low, go slow! • Children – ½ dose • Elderly – ½ dose • Pregnant – avoid • Kidney, liver – ½ dose
  • 26.
  • 27. Side effects • Dopamine blockade – Endocrine dysfxn • Hyperprolactinemia • Menstrual dysfxn • Sexual dysfxn – Movement d/o • Akathisia • Dystonia • Parkinsonism • Tardive dyskinesia
  • 28. Side effects • Antiadrenergic (α1) - NE – Dizziness – Postural hypotension – Reflex tachycardia
  • 29. Side effects • Antihistaminergic – Hypotension – Sedation – Weight gain
  • 30. Side effects • Muscarinic blockade (Ach) – Red as a beet - drowsiness – Dry as a bone – constipation, urinary retention, dry mouth – Blind as a bat – blurred vision – Mad as a hatter – incl sz, drowsiness
  • 31. Side effects • Serotonin – Mania – Depression
  • 32. Serotonin syndrome • Rapid onset of symptoms • 60% present within 6 hours after initial use of medication, an overdose, or a change in dosing • Mental status changes: confusion, restlessness, agitation, anxiety, decreased level of consciousness • Neuromuscular abnormalities: tremor, rigidity, clonus, myoclonus, hyperreflexia, ataxia • Autonomic hyperactivity : diaphoresis, hyperthermia, shivering, mydriasis, nausea, diarrhea • Vital signs: tachycardia, labile BP changes
  • 33. Treatment SS • Discontinuation of all serotonergic agents • Supportive care, many do not require tx • Consult with a medical toxicologist, clinical pharmacologist, or poison control center • Cyproheptadine (serotonin antagonist) • Intubation and ventilation : severe SS with hyperthermia (a temp.> 41.1°C)
  • 34. Other side effects • Blood dyscrasias (agranulocytosis) • Allergic reactions • Anorexia • Cardiac conduction abnormalities • Nausea • Vomiting • Seizures
  • 38.
  • 39.
  • 40.
  • 41. Additional arms • Risperidone - α • Quetiapine – M1, H1, α • Olanzapine – D1, D3, D4, M1, H1, α • Ziprasidone - ?
  • 42.
  • 43. EPS treatment • Be ready to give O2 if breathing problems develop. • PO, IM or IV diphenhydramine (Benadryl) 50mg q 4-5 hrs. IV form acts very quickly so great to use if pt has IV access already. If not may need to use IM. IM takes about 30 minutes to improve sx and po takes around 60 minutes. • Benztropine (Cogentin) 1-2mg PO or IM q 8-12 hours.
  • 44. Breastfeeding • Typicals  reports of toxicity/developmental delays • Atypicals - ORQA Risperidone Olanzapine No toxicity in case reports Quetiapine No neurodevelopment delays in children followed up to 3 years; low transfer Clozapine High accumulation in breast milk; report of infant seizure Aripiprazole Milk: plasma ratio same as other atypicals Ziprasadone No adverse effects reported 2014 APA Presentations
  • 45. Pregnant – placental transfer • No congenital malformations- ORQC – Olanzapine – Risperidone – Quetiapine – Clozapine • Atypical antipsychotics : may cause short-term delay of cognitive, motor, social-emotional, and adaptive behavior development 2014 APA Presentations
  • 48. SNRI • Venlafaxine (Effexor) • Desvenlafaxine (Pristiq) • Duloxetine (Cymbalta)
  • 49. NaSSA • Noradrenergic and Specific Serotonergic Antidepressant • Mirtazapine • Blocks α2  inc NE • 5HT2 and 5HT3 blocker  inc serotonin
  • 50. SSRI • Selective Serotonin Reuptake Inhibitor – Fluoxetine (Prozac) – Fluvoxamine (Faverin) – Sertraline (Zoloft) – Citalupram (Lupram) – Escitalupram (Lexapro) – Paroxetine (Paxil, Seroxat)
  • 51.
  • 52.
  • 53.
  • 54. SSRI side effect • Sexual dysfunction • Headache • Nervousness • Insomnia • Anxiety • Tremor • Drowsiness
  • 55.
  • 56.
  • 58. Mood Stabilizers • Regulate norepinephrine • Regulate dopamine • Regulate serotonin • Increase GABAB receptors in hippocampus
  • 59. Table on Medications for Bipolar Disorders Acute Phase Mantena nce Phase Rapid Cycling Co-morbid Substance Abuse Advantages Lithium   Valproate     Lesser laboratory monitoring; Rapid response (3d); IV preparation available Carbamazepine Oxcarbamazepine    Antipsychotics 
  • 60. Lithium • 1st line • Advantages: – Safest with Liver Dx • Narrow therapeutic window – 0.9-1.4 mmol/Li (Serum)
  • 61. Lithium • Side effects: – Polyuria – polydypsia – weight gain – cognitive problems – impaired coordination – Acne – hair loss – slurred speech – Hypothyroidism – fine hand tremor – Confusion – severe GI effects
  • 62. Carbamazepine Oxcarbamazepine • Effective specially for early onset • Side effects: – Stevens Johnson – Constipation – dry mouth – Nausea – Dizziness – Sedation – Headache – decreased WBC
  • 63. Valproate • Advantages: – IV preparation available – Wide therapeutic window • Side effects: – anorexia – gastrointestinal distress (min Depakote) – Tremor – Sedation – risk for hepatotoxicity
  • 64. Problem Areas Elderly CVD Kidney Liver DM Pregnant Breast- feeding Lithium M M H L L M H Valproate M L H H M H L Carbamazepine L M M L L M L Oxcarbamazepine L M H M L M L
  • 66. Anxiolytics 1. Benzodiazepines (BZD) a. Short acting • Alprazolam, bromazepam, lorazepam, oxazepam b. Long acting • Clonazepam, diazepam, clorazepate 2. ß blockers – Propanolol, oxprenolol 3. Buspirone
  • 67.
  • 68. Other Anti-anxiety agents 1. SSRI 2. SNRI 3. NaSSA
  • 69. Adverse effects of BZD 1. CNS depression – drowsiness, excessive sedation, impaired motor coordination, confusion,& memory loss 2. Paradoxical reactions – excitement, stimulation,& hyperactivity 3. Amnesia 4. can affect the GIT 5. can produce allergic reaction
  • 70. Drug Interaction • BZD enhance effects of – alcohol, barbiturates, phenothiazines, opioids • increase in the effects of BZD – Inhibitors of oxidative metabolism • ascimitidine, disulfiram, isoniazid & omperazole
  • 71. ECT Theories • All–or-nothing Sz (not all parts same) • Generalized central Sz spreads through cortex • Postictal suppression = 90 sec • High-voltage delta and theta waves = “aftershock” • Inc cerebral blood flow • Inc permeability of blood-brain barrier
  • 72. Patient preparation • NPO 6hrs prior • Mouth check • IV • Bite block • O2 5 li/min • Emergency ABC kit
  • 73. ECT • Placement : Frontotemporal – Bilateral – Unilateral (right) • Sz threshold higher – for men and elderly – Inc head size • Use 50% Sz threshold bilateral; 100% unilateral = 25-150 sec Sz • Overdose – TID, Sz 3 hrs
  • 74. Contraindications 1. SOL 2. High ICP 3. Intracerebral bleed (1 month PTA min) 4. Recent MI (3 months PTA min) 5. Retinal detachment 6. Pheochromocytoma 7. High anesthesia risk
  • 77. Psychotherapy on the Brain •Normalization of synaptic and metabolic activity in the limbic and prefrontal regions •increased binding to 5HT1A receptors - Barsaglini et al (2013) Journal of Psychoneurobiology - Collerton (2013) Frontiers in Psychology - Karlsson (2011) Psychiatric TImes
  • 78. Types of Psychotherapy 1. Psychoanalysis – Ego psychology 2. Psychoanalytic Psychotherapy – object relations 3. Behavioral Therapy - Skinner 4. Cognitive Psychotherapy – Beck 5. Cognitive Behavioral Psychotherapy – combination 6. Supportive Psychotherapy 7. Group Therapy 8. Family Therapy 9. Play Therapy
  • 79. Basic rules • Sit at eye level • Sit at arm’s length to 2 arm’s length away • Do not cross your arms • Dress appropriately • Do not touch patient • Allow to cry, do not touch when crying • Religion and Psychiatry do not mix
  • 81. Psychoanalysis • Id-ego-superego • Defense mechanisms • Px = analysand • Therapist = analyst
  • 82. Tasks of analyst • Help patient gain insight so unconscious becomes conscious – Self-knowledge • Techniques – Neutrality – Confrontation – Interpretation – Reconstruction • Transference neurosis
  • 83. Play Therapy You can discover more about a person in an hour of play than in a year of conversation. - Plato
  • 84. Why Play Therapy • Children may not be able to verbalize specially with trauma • Toys act as words for children • Play act as language for children
  • 85. Play Therapy Goals • Explore and express feelings • Restore/ boost self-acceptance, self-confidence, self-reliance • Encourage ability to make good decisions
  • 86. Rules • Do not reprimand • No right or wrong • Do not require/ force • Child has a right to remain silent • Growth cannot be rushed • Therapist must be playful and fun-loving • Therapist must be self-confident and self-reliant