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Vacina Anti HIV Mais de 30 anos depois, onde estamos?

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Vacina Anti-HIV

Mais de 30 anos depois, onde estamos?

Published in: Health & Medicine
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Vacina Anti HIV Mais de 30 anos depois, onde estamos?

  1. 1. Alexandre Naime Barbosa MD, PhD Professor Doutor - Infectologia 20º Encontro Nacional de Biomedicina Out/2017 - Botucatu - SP - Brasil
  2. 2. Declaro ter recebido incentivos na forma de inscrições de eventos científicos e/ou; viagens aéreas e terrestres e/ou; gastos com alimentação, hospedagem e translados e/ou; patrocínio para a realização de congressos; pagamentos por serviços prestados e/ou consultorias das seguintes empresas ou instituições nos últimos 12 meses: - Abbvie - Bristol-Myers Squibb - CNPq - DECIT - FAMESP - Gilead - GSK-ViiV - Jansen - Ministério da Saúde - DDAHV - Merck Sharp and Dohme - Prefeitura de Botucatu - SMS - Sociedade Brasileira de Infectologia - Sociedade Paulista de Infectologia - UNESCO - UNESP
  3. 3. O material que se segue faz parte do projeto didático do Prof. Dr. Alexandre Naime Barbosa Objetivos 1. Ensino: Treinamento de Estudantes e Profissionais da Área de Saúde; 2. Extensão: Facilitar o Contato da População em Geral com Conceitos Científicos; 3. Científico: Fomentar a Discussão Científica e Compartilhar Material Didático. Autoria e Cessão 1. Conteúdo: Os dados contidos estão referenciados, em respeito ao autor original; 2. Uso: Está permitido o uso do material, desde que citada a fonte; 3. Contato: fale com o autor e conheça o seu projeto didático em:
  4. 4. Preventiva - Estimula sistema imunológico a impedir a infecção (anticorpos e ativação de resposta celular) Terapêutica - Estimula sistema imunológico a lutar contra a infecção
  5. 5. HIV Vacina Terapêutica Vacina Preventiva
  6. 6. Unaids - Aids Epidemic Update, 2017 1981-2016: 76,1 milhões de casos 1981-2016: 40 milhões de mortes 2016: 36,7 milhões de PVHA 2016: 19,5 milhões de PVHA em TARV 2016: 1,8 milhões de casos novos 2016: 1,0 milhões de mortes
  7. 7. Brasil, MS - 2016 Prevalência Absoluta: 850 mil [700 mil – 1 milhão] de PVHA Prevalência Relativa: 0,4 a 0,7 % da população em geral Incidência Absoluta: 48.000 casos novos Mortalidade: 12.500 de óbitos em PVHA
  8. 8. Brasil - Ministério da Saúde - BEP HIV/Aids, 2016
  9. 9. Slide cedido pelo dr. Fábio Mesquita - Epidemia presente em todas as segmentos - Concentrada em populações vulneráveis
  10. 10. Brasil - Ministério da Saúde - BEP HIV/Aids, 2016
  11. 11. A JH K I G F E D C B
  12. 12. Brasil, Ministério da Saúde - Pesquisa de Conhecimentos, Atitudes e Práticas na População Brasileira (PCAP), 2014
  13. 13. Vacinas Profiláticas Vacinas Profiláticas
  14. 14. < 72h, chance de impedir a formação de pró-vírus, ARVs impedem a perpetuação da infecção Infecção crônica pelo HIV, ARVs controlam replicação, mas não esterilizam as células
  15. 15. PEP: O que é? - Proteção Pós Exposição de Risco - Funciona até 72 horas - Exposição Sexual Consentida - Violência Sexual - Exposição Ocupacional - 3 cps, 1 x/dia, por 28 dias - Altíssima Eficácia, Urgência Médica - 451 Locais no Estado de São Paulo: www3.crt.saude.sp.gov.br/profilaxia/hotsite
  16. 16. PrEP: O que é? - Proteção Pré Exposição de Risco - Populações ↑ Vulnerabilidade - 1 cp, 1 x/dia, uso contínuo - Altíssima eficácia - Aprovado nos EUA e Europa - Em Estudo Clínico no Brasil - Ainda não aprovado pela ANVISA (Set/2016)
  17. 17. Dados Científicos até hoje - Não há relato de transmissão do HIV de fonte virologicamente suprimida
  18. 18. Diaz R, 2014
  19. 19. Hutter G, et al N Engl J Med, 2009.
  20. 20. Prova de Conceito que a Cura do HIV é Possível! Mas ainda pouco factível...
  21. 21. No futuro...
  22. 22. Principais Modelos
  23. 23. Principais Modelos
  24. 24. Principais Modelos
  25. 25. Principais Modelos
  26. 26. Principais Modelos
  27. 27. Alguns entraves - Epítopos inacessíveis - Escape antigênico - Existência de muitos cepas virais
  28. 28. Fauci A, 2017
  29. 29. Fauci A, 2017
  30. 30. Fauci A, 2017
  31. 31. Fauci A, 2017
  32. 32. Fauci A, 2017
  33. 33. Fauci A, 2017
  34. 34. Fauci A, 2017
  35. 35. Fauci A, 2017
  36. 36. Fauci A, 2017
  37. 37. Fauci A, 2017
  38. 38. Fauci A, 2017
  39. 39. Fauci A, 2017
  40. 40. Fauci A, 2017
  41. 41. Fauci A, 2017
  42. 42. Fauci A, 2017
  43. 43. Fauci A, 2017
  44. 44. Fauci A, 2017
  45. 45. Fauci A, 2017
  46. 46. Fauci A, 2017
  47. 47. Fauci A, 2017
  48. 48. Fauci A, 2017
  49. 49. Fauci A, 2017
  50. 50. Fauci A, 2017
  51. 51. Fauci A, 2017
  52. 52. Fauci A, 2017
  53. 53. Fauci A, 2017
  54. 54. Fauci A, 2017
  55. 55. Fauci A, 2017
  56. 56. Abdool Karim S, Abdool Karim Q, et al. Lancet. 2011;378:e23-e25.
  57. 57. Fauci A, 2017
  58. 58. Obrigado pela Atenção! SAE de Infectologia HC UNESP Botucatu Faculdade de Medicina UNESP

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