This document provides an overview of critical challenges facing sustainable water resource management including increasing costs of developing new water supplies, wasteful use of existing water, degradation of irrigated cropland, and groundwater depletion. It outlines a research agenda to understand how policies and institutions can help address these challenges through more effective water management, increased food production, poverty alleviation, and environmental sustainability. The goals are to understand the impacts of alternative policies on water, poverty, ecosystems, and food security and utilize this to help develop sustainable water management strategies.