This document contains a series of questions about various antidepressant drugs. It addresses topics like the mechanisms of action, side effects, drug interactions, and indications for different classes of antidepressants including SSRIs, TCAs, MAOIs, atypical antidepressants, and lithium. The questions are multiple choice format and cover key details about these common antidepressant medications.

1. PCOL 324: Pharmacology-II
Tutorials: Antidepressants

2. Antidepressants
• Indicate true OR false:
A. In Major Depression Disorder periods of
mania alternate or occur simultaneously with
depressive symptoms. (T/F).
B. Unipolar depression is characterized by
depressed mood and sleep disturbances (T/F).
C. TCAs are Relatively safe even in overdose
(T/F).

3. Antidepressants
• Indicate true OR false:
A. Bupropion inhibits the reuptake of both
serotonin and NE (T/F).
B. MAOIs have high risk for drug– drug and
drug–food interactions (T/F).
C. Thyroid function may be increased by lithium
(T/F).

4. Antidepressants
• The therapeutic response to antidepressant
drugs is usually over a period of:
A. 24 hours
B. 2-3 days
C. 2-3 weeks
D. 5-6 month

5. Antidepressants
• All of the following are selective serotonin
reuptake inhibitor EXCEPT:
A. Fluvoxamine.
B. Paroxetine.
C. Imipramine.
D. Citalopram.

6. Antidepressants
• All of the following about selective serotonin
reuptake inhibitors (SSRIs) are true EXCEPT:
A. They are relatively safe even in overdose.
B. All of the SSRIs are well absorbed after oral
administration.
C. The primary indication for SSRIs is Bipolar
depression.
D. Their doses should be reduced in case of
hepatic impairment.

7. Antidepressants
• All of the following about Fluoxetine are true
EXCEPT:
A. It has a shorter half life.
B. It is an inhibitor of CYP2D6 that is responsible
for the elimination of TCAs.
C. It metabolized to active metabolite.
D. It has the lowest risk of causing an SSRI
discontinuation syndrome.

8. Antidepressants
• The following SSRI can cause cardiac
arrhythmias:
A. Sertraline.
B. Fluvoxamine.
C. Paroxetine.
D. Citalopram.

9. Antidepressants
• Venlafaxine is a:
A. A selective serotonin reuptake inhibitor.
B. A selective norepinephrine reuptake inhibitor.
C. Inhibitor of both serotonin and
norepinephrine reuptake.
D. Atypical antidepressant.

10. Antidepressants
• Which antidepressant has, as its two
principle mechanisms of action, 5-HT2A
receptor antagonism and α2 receptor
antagonism?
A. Duloxetine.
B. Bupropion.
C. Mirtazapine.
D. Trazodone.

11. Antidepressants
• A 30 -year-old man has a long history of
depressive symptoms accompanied by
migraine headache and neuropathic pain
Which of the following drugs might be useful
in this patient?
A. Fluoxetine.
B. Amitriptyline.
C. Phenelzine.
D. Mirtazapine.

12. Antidepressants
• All of the following are atypical
antidepressant EXCEPT:
A. Mirtazapine.
B. Doxepin.
C. Bupropion.
D. Nefazodone.

13. Antidepressants
• Which of the following agents is related to
tricyclic antidepressants?
A. Nefazodone.
B. Imipramine.
C. Fluoxetine.
D. Tranylcypromine.

14. Antidepressants
• The following is TCA adverse effect/s:
A. Xerostomia.
B. Blurred vision.
C. Weight gain.
D. All of the above.

15. Antidepressants
• 60 -year-old man with symptoms of major
depression also has narrow-angle glaucoma.
Which of the following antidepressants
should be avoided in this patient?
A. Mirtazepine.
B. Bupropion.
C. Amitriptyline.
D. Sertraline.

16. Antidepressants
• Which of the following antidepressants have
high potential for drug-food and drug-drug
interactions:
A. Selective serotonin reuptake inhibitors (SSRIs).
B. Tricyclic Antidepressants (TCAs).
C. Monoamine oxidase inhibitors (MAOIs).
D. Atypical antidepressants.

17. Antidepressants
• The irreversible MAO inhibitors have a very
high risk of developing:
A. Respiratory depression.
B. Cardiovascular collapse and CNS depression.
C. Hypertensive reactions to tyramine ingested
in food.
D. Potentially fatal agranulocytosis.

18. Antidepressants
• All of the following about lithium are true
EXCEPT:
A. Lithium salts are used in the treatment of
manic episodes.
B. Lithium is given orally, and the ion is excreted
by the kidney.
C. Lithium has wide therapeutic index.
D. adverse effects include diabetes insipidus
and decreased thyroid function.