![Radioiodine (I[3]1)](https://image.slidesharecdn.com/presentation2-201119091332/85/Thyroid-Hormone-45-320.jpg)
More Related Content
Thyroid Hormone
- 1. Thyroid Hormone Prepared By:-Miss Anamika Singh
- 2. Thyroid Gland The thyroidgland is the largest ,butterfly-shaped endocrine gland and is located at the base of the neck immediately below the larynx on each side of &anterior to the trachea . The thyroid gland consist of 2 Types of cells. Follicular cells:- These are more abundant ,and the major secretary cells. They secrete thyroid harmone. Para follicular cells or c-cells:-These are fewer in number &interspersed They Secrete Calcitonin.
- 3. Follicular Cells- TheFunctional Unit
- 4. Thyroid Hormone The Thyroidgland secretes 3 Major hormones:- Thyroxin or T4 :- Having 4 atom of Iodine .(secreted in largest amount) Triiodothyronine or T3:- Having 3 atom of iodine (secreted in lesser amount) Calcitonin:- Which is an important hormone of calcium metabolism .
- 5. Pharmacological Action ofThyroid Hormone Metabolic Function:- CHO Metabolism Glycogenolysis Increase gluconeogensis Glucose absorption from GIT Enhance glycolsis –rapid uptake of glucose by the cell Net Result –blood Glucose level On protein metabolism :- protein catabolism On Fat metabolism :- Mobilization of Fat Oxidation of FA FFA On BMR:- BMR
- 6. Growth:- growth On GIT:- -Appetite & food intake . - Rate of Secretion of Digestive juice - Motility of GIT Diarrhea often result in hypertension On CVS:- -Enhance tissue sensitivity to catecholamine's - Cardiac Output On Nervous System :- Excitable effect Has role on development of brain in Fetal & 1st few week of postnatal life . Muscle weakness due to protein catabolism.
- 7. DIFFERENCE BETWEEN T4& T3 -The thyroid Secretes about 80 micrograms of T4, But only 5 Microorganism Of T3 ,Per Day . -However, T3 has a Much greater Biological activity (about 10X) than T4. - An additional 25 micrograms/ day of T3 is Produced by Peripheral monodeiodination of T4.
- 8.
- 9.
- 10. Biosynthesis Of Thyroid Hormones -Ingestionof iodide -Activation of iodide (peroxidase) iodations of tyrosine -coupling (peroxidase) -Release (Proteolytic Enzyme) -Iodide is actively transported to thyroid gland .Iodide is oxidized to iodine by thyroid peroxidase ,which is turn iodinates tyrosine residues of the thymoglobulin (TG) to form monoiodotyrosine (MIT) and diiodotyrosin (DIT) .The Coupling of two DIT form T4 and the coupling of one MIT and DIT forms T3 . The Process Of Coupling is also Catalyzed by Thyroid peroxidase .T4 and T3 are released by proteolysis.
- 11.
- 12.
- 13.
- 14. Thyroid Hormone Synthesis 4)Storage and release 5) Peripheral Conversion
- 15. Transport, Metabolism andExcretion - Kinetics
- 16.
- 17. Thyroid Regulation Regulation ofThyroid Function :- Negative Feedback by Thyroid hormone is Exercised Directly on Pituitary and Hypothalamus .
- 18. Relation of iodineto Thyroid Function
- 19.
- 20. MOA – ThyroidHormones
- 21.
- 22.
- 23.
- 24.
- 25.
- 26.
- 27.
- 28.
- 29.
- 30. Myxoedema Coma –Treatment
- 32. Choice of TreatmentFor Hyperthyroidism
- 33.
- 34. Anti Thyroid Drugs-ModeOf Action
- 36. Anti- Thyroid Drug– Contents
- 37. Clinical Uses- AntiThyroid
- 38.
- 39. Role Of B-Adrenergic Blocker
- 40. Thyroid Storm OrCrisis
- 41. Thyroid Storm orCrisis- Treatment
- 42. Block and ReplaceRegimen
- 43.
- 44.
- 45.