- Severe sepsis accounts for 21,000 cases per year in the hospital, representing 27% of ICU admissions and 46% of bed days. About 60-70 cases of severe sepsis occur per year. - A sepsis bundle involving early lactate measurement, blood cultures, antibiotics, fluids and vasopressors if needed, and inotropes for certain patients has been shown to significantly reduce mortality when all elements are executed together within a specified time frame. - Key elements of the sepsis bundle include measuring lactate, administering antibiotics within 1 hour, IV fluids for hypotension or high lactate, and achieving certain hemodynamic and oxygenation goals through fluids and vasopressors if needed, all to be