This document provides an overview of best practices for programmatic advertising. It discusses common challenges media companies face with direct sales such as fragmented operations, technology, and yield optimization. It then outlines Operative's solution to integrate all aspects of digital advertising into a single operating system. The document also reviews the current programmatic landscape, including real-time bidding strategies and challenges around header bidding. It provides examples of optimal programmatic infrastructure, inventory segmentation, staffing, and header bidding setup. The goal is to help media companies maximize revenue across direct, programmatic direct, and real-time bidding sales channels.