DHA plays an important role in brain health throughout life. Research shows that DHA is essential for brain development in infants and children, and may help maintain optimal brain function in teens, adults and seniors. While recommendations for DHA intake are not well defined, studies suggest amounts of 150-250 mg per day are beneficial for brain health across different age groups. Bioriginal has developed neural health products containing DHA tailored to different life stages to support healthy brain development and function.
DHA plays an important role in brain health throughout life. Studies show that adequate maternal DHA intake during pregnancy and breastfeeding is associated with improved infant development and behavior. DHA supplementation in children and adolescents supports optimal brain and cognitive function. Higher DHA status is also linked to a reduced risk of cognitive decline and conditions like Alzheimer's disease in older adults. While recommendations focus on heart health, the levels suggested may be sufficient to support brain health across all life stages.
The Relationship Between HCAHPS and Facilities: How to Improve Scores In New ...BSA LifeStructures
In the healthcare world, results are defined by outcomes and patient satisfaction. Healthcare executives across the country are facing questions on how their organization can improve patient satisfaction and, as a result, scores on the Hospital Consumer Assessment of Health Care Providers and Systems (HCAHPS) survey. The importance of patient satisfaction results have evolved since the introduction of healthcare reform—which affects hospitals’ reimbursement partly based on scores they receive on the HCAHPS.
Healthcare facility planners and designers have the responsibility to create a physical environment that enables improved results. After all, creating an atmosphere in hospitals that is safe, clean and quiet makes patients more comfortable and more likely to heal. The ability to identify the design elements that contribute to a healthy and positive patient experience allows hospitals to institute operational plans and design solutions that improve healing.
In this presentation, planning and design experts from BSA LifeStructures will discuss the impact a hospitals’ environment can have on patients and then present design recommendations that have been proven to improve satisfaction scores and value for the hospital. BSA LifeStructures has developed methods to track the impact of design solutions in hospitals. And, in doing so, have given healthcare organizations a valuable tool to determine the value and effectiveness of their healing environment.
The epicenter of patient experience is generally focused on the patient room.
The different human interactions within the patient room create the paradigm for defining the patient experience…the people, the process and the place.
People—the physical space of the patient room can contribute to engaging the caregiver by providing plenty of natural light, giving caregivers adequate space to work, and planning spaces that combine multiple functions.
Process—Lean design principles should be used to improve the caregiver’s workflow and limit the number of value-wasted movements. By making their job more efficient they can save energy and leverage opportunities for rest and respite.
Place—the physical space needs to be quiet and clean. Using easy-to-clean flooring materials and designing patient rooms to limit room-to-room and corridor-to-room noise transfer enables the space to address typical areas for satisfaction shortfalls.
These three interactions need to work well collaboratively in order to yield a satisfactory patient experience and quality HCAHPS scores. It is the cause and effect flow to HCAHPS scores.
SEO is composed of onsite and offsite optimization. Onsite refers to elements on a website like keywords, URLs, page content and social media integration. Offsite refers to external elements like blogging, social bookmarks and forums. The document discusses optimizing a website for SEO through onsite and offsite techniques, using the My Viral Web tool to add campaigns and track backlinks to find where competitors are mentioned in order to increase online presence.
Using Simulation to Orchestrate Memorable Learning ExperiencesBSA LifeStructures
The key to successful simulation is the experience. A successful simulation center supports the academic and clinical mission, while also creating realistic spaces that advance the education of students and provide hands-on experience in a risk-free environment. But how do you orchestrate an experience that students learn and grow from? This presentation focuses on the different types of simulation environments, their varying levels of fidelity and how Marian University uses simulation as a catalyst for memorable learning.
This document discusses selecting methods, media, and materials for instruction. It covers several key points:
1. Teachers must select instructional methods like motivation, application, orientation, and evaluation. They should use a methods selection checklist.
2. Teachers must also select appropriate instructional media like multimedia, video, graphics, audio, and text using a media selection checklist.
3. When selecting specific materials, teachers should determine needs, check various sources, obtain and preview materials, try them with students, and compare options. They can modify existing materials or create new ones.
Teachers must consider copyright issues and exceptions when using others' materials. The overall goal is to help students learn to select criteria for
DHA plays an important role in brain health throughout life. Studies show that adequate maternal DHA intake during pregnancy and breastfeeding is associated with improved infant development and behavior. DHA supplementation in children and adolescents supports optimal brain and cognitive function. Higher DHA status is also linked to a reduced risk of cognitive decline and conditions like Alzheimer's disease in older adults. While recommendations focus on heart health, the levels suggested may be sufficient to support brain health across all life stages.
The Relationship Between HCAHPS and Facilities: How to Improve Scores In New ...BSA LifeStructures
In the healthcare world, results are defined by outcomes and patient satisfaction. Healthcare executives across the country are facing questions on how their organization can improve patient satisfaction and, as a result, scores on the Hospital Consumer Assessment of Health Care Providers and Systems (HCAHPS) survey. The importance of patient satisfaction results have evolved since the introduction of healthcare reform—which affects hospitals’ reimbursement partly based on scores they receive on the HCAHPS.
Healthcare facility planners and designers have the responsibility to create a physical environment that enables improved results. After all, creating an atmosphere in hospitals that is safe, clean and quiet makes patients more comfortable and more likely to heal. The ability to identify the design elements that contribute to a healthy and positive patient experience allows hospitals to institute operational plans and design solutions that improve healing.
In this presentation, planning and design experts from BSA LifeStructures will discuss the impact a hospitals’ environment can have on patients and then present design recommendations that have been proven to improve satisfaction scores and value for the hospital. BSA LifeStructures has developed methods to track the impact of design solutions in hospitals. And, in doing so, have given healthcare organizations a valuable tool to determine the value and effectiveness of their healing environment.
The epicenter of patient experience is generally focused on the patient room.
The different human interactions within the patient room create the paradigm for defining the patient experience…the people, the process and the place.
People—the physical space of the patient room can contribute to engaging the caregiver by providing plenty of natural light, giving caregivers adequate space to work, and planning spaces that combine multiple functions.
Process—Lean design principles should be used to improve the caregiver’s workflow and limit the number of value-wasted movements. By making their job more efficient they can save energy and leverage opportunities for rest and respite.
Place—the physical space needs to be quiet and clean. Using easy-to-clean flooring materials and designing patient rooms to limit room-to-room and corridor-to-room noise transfer enables the space to address typical areas for satisfaction shortfalls.
These three interactions need to work well collaboratively in order to yield a satisfactory patient experience and quality HCAHPS scores. It is the cause and effect flow to HCAHPS scores.
SEO is composed of onsite and offsite optimization. Onsite refers to elements on a website like keywords, URLs, page content and social media integration. Offsite refers to external elements like blogging, social bookmarks and forums. The document discusses optimizing a website for SEO through onsite and offsite techniques, using the My Viral Web tool to add campaigns and track backlinks to find where competitors are mentioned in order to increase online presence.
Using Simulation to Orchestrate Memorable Learning ExperiencesBSA LifeStructures
The key to successful simulation is the experience. A successful simulation center supports the academic and clinical mission, while also creating realistic spaces that advance the education of students and provide hands-on experience in a risk-free environment. But how do you orchestrate an experience that students learn and grow from? This presentation focuses on the different types of simulation environments, their varying levels of fidelity and how Marian University uses simulation as a catalyst for memorable learning.
This document discusses selecting methods, media, and materials for instruction. It covers several key points:
1. Teachers must select instructional methods like motivation, application, orientation, and evaluation. They should use a methods selection checklist.
2. Teachers must also select appropriate instructional media like multimedia, video, graphics, audio, and text using a media selection checklist.
3. When selecting specific materials, teachers should determine needs, check various sources, obtain and preview materials, try them with students, and compare options. They can modify existing materials or create new ones.
Teachers must consider copyright issues and exceptions when using others' materials. The overall goal is to help students learn to select criteria for
Omega 3 overview - professor philip calder eng1iTech-llc
This lecture covers omega-3 fatty acids, including their sources, metabolism, and health benefits. It discusses the metabolic relationship between alpha-linolenic acid and long chain omega-3 fatty acids like EPA and DHA. It reviews evidence that omega-3 fatty acids may benefit cardiovascular health as well as visual and brain development. The lecture concludes that long chain omega-3 fatty acids have important physiological effects and may lower the risk of many diseases through plausible biological mechanisms.
The opening scene of Limitless uses a blurred tracking shot through the city to create a sense of speed and tension. Billboards showing brain images and neurons suggest the main character is under the influence of drugs. Shots of his messy apartment indicate his life is disorganized and isolated. The character is shown pitching his book to disinterested men in a pub, making him seem lonely and unimportant. Overall the fast-paced opening establishes the thriller genre and leaves the audience wanting more.
The document discusses the history and development of artificial intelligence over the past 70 years. It outlines some of the key milestones in AI research including the creation of logic theories, machine learning algorithms, and neural networks. Recent advances in deep learning have helped AI systems match and even surpass human-level performance in certain tasks such as image recognition.
Omega 3 overview - professor philip calder eng1iTech-llc
This lecture covers omega-3 fatty acids, including their sources, metabolism, and health benefits. It discusses the metabolic relationship between alpha-linolenic acid and long chain omega-3 fatty acids like EPA and DHA. It reviews evidence that omega-3 fatty acids may benefit cardiovascular health as well as visual and brain development. The lecture concludes that long chain omega-3 fatty acids have important physiological effects and may lower the risk of many diseases through plausible biological mechanisms.
The opening scene of Limitless uses a blurred tracking shot through the city to create a sense of speed and tension. Billboards showing brain images and neurons suggest the main character is under the influence of drugs. Shots of his messy apartment indicate his life is disorganized and isolated. The character is shown pitching his book to disinterested men in a pub, making him seem lonely and unimportant. Overall the fast-paced opening establishes the thriller genre and leaves the audience wanting more.
The document discusses the history and development of artificial intelligence over the past 70 years. It outlines some of the key milestones in AI research including the creation of logic theories, machine learning algorithms, and neural networks. Recent advances in deep learning have helped AI systems match and even surpass human-level performance in certain tasks such as image recognition.
4. DHA: 22:6 n-3
22:6 n-3
In the brain present as phospholipid
Can be synthesized from ALA (also by Glial cells),
but conversion rates are low.
Innis, 2007
5. DHA: main sources
5% %
15
23-2 12
-
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Tu Sa oi
tl. ish 1 3%
A 2 F r 10- 2%
1 8/1 live 0-1
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Co kere n 9- 10
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ac ade
-4
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l
M
a
h
35
1
en e 9- 10%
Alg
h
M n 8-
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9-10%
9. Nervous system
Complex network of neurons
located throughout our body
Two parts:
Central nervous system and
Peripheral nervous system
Both controlled by the brain
10. Nervous system: The brain
Numerous functions described
to the brain:
Control of body functions
Voluntary (thought>movement)
Involuntary (Heartbeat)
Reason of consciousness,
emotions, memory,
imagination, etc
11. Nervous system: Brain anatomy
Regions (lobes) in the brain have special roles
10 % neurons, 90% glial cells
Picture taken from Stanford University website
13. Brain development
weight
Brain
Late Young-
Pre-birth Early Older
Childhood / Mid age
Childhood adults
adolescence Adult
Trimester 1
Trimester 2
Trimester 3
18 yrs old
55 yrs 0ld
4 yrs old
Death
Birth
14. Nervous system: Brain structure
Lipids main constituent of neuronal cell membrane
Total brain rich in lipids: 50-65 % of dry matter
35 % of lipids are PUFA, mostly DHA
Grey matter, nervous system and retina have highest
concentrations of DHA
A healthy brain is rich in DHA
Sinclair 1975
15. Brain health: genetic factors
Possible genetic variation in Fatty acid binding
proteins (B-FABP)
Dopamine transporter candidate genes for
ADHD
Occurrence of apolipoprotein epsilon-4 allele is
associated with Alzheimer
Noguchi et al, 1993
Owada et al, 2006
Veerkamp and Zimmerman, 2001
16. Role of DHA in building and
maintaining optimal brain
function
17. Western diet: High in n-6’s :
LA and AA
Linoleic Acid (LA) Alpha-Linolenic Acid
(ALA)
D6D Enzyme
Gamma-Linolenic Acid Stearidonic Acid
(GLA)*
Elongase
Dihomo-Gamma-Linolenic Eicosatetraenoic Acid
Acid (DGLA)* (20:4n-3)
D5D Enzyme
Arachidonic Acid (AA) Eicosapentaenoic Acid
(EPA)
Elongase
Elongase
Longer Chain Fatty Acid
Metabolites Desaturase
Docosahexaenoic Acid
(DHA)
18. Western diet: n3 mostly ALA from plant sources
Linoleic Acid (LA) Alpha-Linolenic Acid (ALA)
D6D Enzyme
Gamma-Linolenic Acid Stearidonic Acid
(GLA)*
Elongase
Dihomo-Gamma-Linolenic Eicosatetraenoic Acid Conversion:
Acid (DGLA)* (20:4n-3) slow
Possible shortage of DHA in the body
D5D Enzyme
Arachidonic Acid (AA) Eicosapentaenoic Acid
(EPA)
Elongase
Elongase
Longer Chain Fatty Acid
Metabolites Desaturase
Docosahexaenoic Acid
(DHA)
Williams and Burdge, 2006
19. Split up:
Development/Decline vs Problems
Pre-birth Late Young-
Early Older
Childhood / Mid age
Childhood adults
adolescence Adult
Research focused Research
on “problems” focused
on development
and decline
20. Brain development: Uptake and incorporation
Uptake DHA around 60%, usually higher for ALA
10-20 % used for energy (B-oxidation)
Incorporation into brain cells phospholipids
highly dependent on ARA in the diet.
Higher DHA intake leads to Higher DHA status in
the brain.
Moya et al, 2001
Mayes et al, 2006
21. Effect of dietary intake ARA and DHA upon
DHA status in Frontal lobe of the Cerebral cortex
% DHA
In baboon
frontal lobe
after *
*
12 wks
9.8 12.8 13.9
C L L3
Diets:
Control No added PUFA
L 0.42% DHA (+ 39 mg/Kcal ARA)
L3 1.13% DHA (+ 39mg/Kcal ARA) Interpreted from Hsieh et al, 2007
22. Brain development: Effect of maternal DHA intake
Set-up:
Pregnant women on 2 diets (randomised:
Corn oil
Cod liver oil (+/- 1200 mg DHA)
18 wks in Pregnancy -> 3 months breastfeeding
Intelligence test at 4 yrs of age (n=90)
Helland et al, 2003
23. Brain development: Effect of maternal DHA intake
K-ABC score
*
107.8
101.7
Corn oil CLO
Interpreted from Helland et al, 2003
24. Brain development: Effect of DHA intake between
0-4yrs
Breastfed infants from mothers taking DHA
supplements showed:
Higher infant PL DHA
higher Index score on Bailey’s Psychomotor (at 30
months)
Infants (6 wks +) fed High PUFA diets (ALA + DHA) showed
improved visual acuity compared to those fed low PUFA
diets.
Jensen et al, 2005
Birch et al, 2002
25. Brain development: DHA & the effect on child
behavior (0-4yrs)
Set-up:
Infants being breastfed (n=20)
Breast milk analysed on lipids
Infants assessed on neurobehavioral functions
(NBAS, 9 point scales)
Hart et al, 2006
26. Brain development: DHA & the effect on child
behavior (0-4yrs)
r=0.57
P<0.01
Lability of
State
(Higher score
is more stable)
DHA in Breast milk
Interpreted from Hart et al, 2006
27. Brain development: Effect of DHA intake during
“adolescence”
Set-up:
3 Mo old mice
Group fed DHA and palm oil
Group fed just palm oil
Measurement = Maze-learning ability at
1 wk, 2wks, 1 Mth, 3 Mths
Lim and Suzuki, 2000
28. Brain development: Time to reach Maze exit
shortens with prolonged DHA diet
Time DHA in
(% control) Brain
bars Lines
Control
Control
Control
Control
DHA
*
DHA
DHA
DHA
1wk 2 wk 1 mth 3 mths
Interpreted from Lim and Suzuki, 2000
29. Brain health Problems & DHA: ADHD
Attention-Deficit Hyperactivity Disorder
Diagnosis difficult, many factors
3-5 % of those under 19 affected
Now believed to continue into adulthood
Common medicine, Ritalin, has shown serious
potential side effects
30. Brain health Problems & DHA: ADHD
Lower plasma PUFA seen in sufferers
Most studies done with Fish oil (DHA + EPA)
Positive effects with fish oil seen in several studies
DHA alone less effective, but symptom
(aggression) decreases with DHA intake (> 2
Richardson and Puri, 2002
Mo), P=0.001 Stevens et al, 2003
Stevens et al, 1995
Hamazaki et al, 2004
31. Brain health Problems & DHA: Depression
Clinical symptoms of depression (glucose metabolism,
Pro-inflammatory cytokine, neurotransmitter concentration):
Increase when deficiency n-3 PUFA exists
Decrease when n-3 PUFA are supplemented
Unclear if effects are due to DHA+EPA or one
the separate components.
Some studies show no effect
Sinclair et al, 2007
Llorente at al, 2003
32. Cognitive decline : A major future problem
Babyboomers getting older
Memory related
problems
increase with aging:
Dementia:
65 and older = 6 %
80 and older = 20%
Forgetfulness >
Dementia >
Alzheimer
Wimo et al, 2003
Crook et al, 1993
34. Cognitive decline : DHA might have benefits
Alzheimer patients have 30 % less DHA in brain
tissue
Epidemiological evidence suggest 180 mg
DHA/day is associated with a 50-60 % reduced
chance of getting dementia
Johnson and Schaefer, 2006
Soderberg et al, 1991
Morris et al, 2003
35. Brain health & DHA: Lifetime dietary effects
Born IQ-test IQ-test
1936 1947 1999-2000
Non -fish oil Non -fish oil
users users
n=60 n=60
IQ: 100.2 IQ: 95.2
Fish oil Fish oil
users users
n=60 n=60
IQ: 100.7 IQ: 105.9
Whalley et al, 2004
36. How much DHA do we need? For optimum brain function
No daily recommended intake defined
Most recommendations on Fish oil and heart health
Defined in some countries:
Pregnant and nursing women : 115-300 mg DHA/day
Infants (0-5 Months): 20 mg/kg/day – 500 mg DHA+EPA
Most Heart health recommendation “fit” with studies on
brain development / cognitive health
Some studies use very high concentrations
37. Bioriginal/MeCompany neural concepts:
The optimum amount of DHA for 3 age
groups:
Young children (150 mg)
Teens (200 mg)
Seniors (250 mg)
With different great flavors (oils and capsules)
Additional supportive vitamins fitting for that age group
38. Conclusions
Research on the effects of DHA and Brain health
still in its’ infancy
DHA shown to play an important role in brain
health throughout life
Dietary recommendations for heart health
probably sufficient for optimum brain health
39. Оmegame® neo
(MeCompany AG, Switzerland)
is the source of DHA for infants-
adults for the formation and
support of the healthy
functioning of nervous system
and brain!
Editor's Notes
Glial cells: support & protection role for Neurons The four main functions of glial cells are to surround neurons and hold them in place, to supply nutrients and oxygen to neurons, to insulate one neuron from another, and to destroy pathogens and remove dead neurons.
High LA + AA, ratio n6:n3 generally hig
High LA + AA, ratio n6:n3 generally hig
The uptake of DHA in brain tissue is established
Kaufman assesment Battery scores for Mental processing composite
Most studies done with fish oil
Most studies done with fish oil
Most studies done with fish oil
Most studies done with fish oil
Most studies done with fish oil
Most studies done with fish oil
Recommendations need closer look by authorities once more evidence is collected.