Photos e discussion courtesy of Nina Zanetti: This specimen is from a 67 y/o WM. A normal portion of the specimen is shown in image B and C. Portions of the lesion appear in all the other imnges. 1. What tissoe is represented by the solid pink framments (best seen in "notmaf" areas, shown in images B and C )? 2. What oells are normally present within the pink substance of this tissue? 3. What additional tissucs are present in the specimen? 4. What alierntions in cells and tisoue architecture tell you that something is wrong ? What general discase process has occumed here? 5. What is the discaee? 6. What histological signs of inflammation are present in the micrographs? For example: What epecial kind of tissue appears in the figures I and I 4 and what role does it have in the inflammatory process? 7. What are the large, thin-walled, hollow structures? 8. What are the star-shaped or elongated cells, and why do they dppear different in this specimen than they do in "normal" tissue? 9. What are the very large, multinucleated cells that appear in Fig J , and what is there function? 10. The articular cartilage also shows some pathological abnormalities. What are they, and what do those aboormalitics add to the diagnosis?.