The document discusses a pathological specimen from a 67-year-old male, highlighting various cellular and tissue characteristics observed through images. It poses multiple questions regarding the tissue type, normal cell presence, additional tissues, signs of disease processes, and specific histological features indicative of inflammation. The document aims to identify abnormalities and their implications for diagnosis based on the specimens presented.

1. Photos e discussion courtesy of Nina Zanetti: This specimen is from a 67 y/o WM. A normal
portion of the specimen is shown in image B and C. Portions of the lesion appear in all the other
imnges. 1. What tissoe is represented by the solid pink framments (best seen in "notmaf" areas,
shown in images B and C )? 2. What oells are normally present within the pink substance of this
tissue? 3. What additional tissucs are present in the specimen? 4. What alierntions in cells and
tisoue architecture tell you that something is wrong ? What general discase process has occumed
here? 5. What is the discaee? 6. What histological signs of inflammation are present in the
micrographs? For example: What epecial kind of tissue appears in the figures I and I 4 and what
role does it have in the inflammatory process? 7. What are the large, thin-walled, hollow
structures? 8. What are the star-shaped or elongated cells, and why do they dppear different in
this specimen than they do in "normal" tissue? 9. What are the very large, multinucleated cells
that appear in Fig J , and what is there function? 10. The articular cartilage also shows some
pathological abnormalities. What are they, and what do those aboormalitics add to the diagnosis?