Numira Bio offers in vitro, in vivo, and ex vivo oncology services including cell culture and screening, xenograft models, and micro-CT scanning and histology. They have experience with over 60 cell lines and provide customized xenograft models for multiple cancer types. Imaging and analysis of tumor vasculature and vascular markers allows evaluation of anti-cancer therapies. Experienced staff support over 100 oncology clients.

1. Oncology
Services
In
Vitro
In
Vivo
Ex
Vivo
Cell
culture
&
screening
Xenogra1
models
μCT
scanning
&
histology
§ TumorScreenTM
(60+
Cell
Lines)
§ Ability
to
translate
tumor
cell
lines
into
§ High-­‐resoluGon
imaging
&
analysis
of
• Prolifera:on
xenograE
studies
tumor
vasculature
• High
sensi:vity
• Tumor
volume
and
surface
area
§ MulGple
xenograE
models
for
prostate,
§ CaspaseScreen
(60+
Cell
Lines)
• Vessel
volume,
radius,
tortuosity,
branching,
lung,
colon,
and
liver
cell
lines
density,
and
distribu:on
depth
• Apoptosis
• 24
hour
or
custom
assay
§ Other
tumor
types
in
development
§ Proprietary
AltaBluTM
imaging
agent
for
§ ComboScreenTM
§ Custom
models
available
3D
vascular
analysis
• 5x5
or
custom
matrix
• Low
toxicity
§ OpGcal
imaging
&
orthotopic
models
• Safer,
easier
to
work
with,
and
permits
more
• Combina:on
index
&
Bliss
analysis
coming
soon
consistent
perfusions
§ 3D
Screen
for
in
vivo-­‐like
gene
expression
• Prolifera:on
§ MulGple
oncology
and
angiogenic
• Custom
cell
lines
markers
of
tumors
for
analysis
using
immunohistochemistry
(IHC)
All
assays
performed
with
a
9-­‐concentra6on
curve
in
quadruplicate
with
luminescent
readout
at
72hrs
unless
otherwise
specified.
3D
Culture
HT-­‐29
XenograE
Vessel
Radius
1200
Tumor
Volume
(mm3)
1000
800
600
Control
400
Paclitaxel
200
0
0
10
20
Days
Post
Treatment
§ Expert
staff
with
20
years
experience
§ 8+
years
of
CRO
experience,
serving
over
100
oncology
clients
oncology@numirabio.com
www.NumiraBio.com
Tel:
801-­‐320-­‐0682