This study analyzed data from 5 clinical trials comparing the effects of filgrastim and pegfilgrastim (G-CSF) to placebo in patients receiving chemotherapy. The results showed:
1) Patients receiving G-CSF had significantly lower rates of severe neutropenia and febrile neutropenia after the first cycle of chemotherapy compared to placebo.
2) Median overall survival was greater for patients receiving G-CSF versus placebo in one lung cancer trial, but the differences were not statistically significant.
3) A meta-analysis of the 3 placebo-controlled trials found a hazard ratio for overall survival of 0.77 favoring G-CSF over placebo, but again the result was not statistically significant. Further studies are
This study analyzed data from 5 clinical trials comparing the effects of filgrastim and pegfilgrastim (G-CSF) to placebo in patients receiving chemotherapy. The results showed:
1) Patients receiving G-CSF had significantly lower rates of severe neutropenia and febrile neutropenia after the first cycle of chemotherapy compared to placebo.
2) Median overall survival was greater for patients receiving G-CSF versus placebo in one lung cancer trial, but the differences were not statistically significant.
3) A meta-analysis of the 3 placebo-controlled trials found a hazard ratio for overall survival of 0.77 favoring G-CSF over placebo, but again the result was not statistically significant. Further studies are
Sampling based approximation of confidence intervals for functions of genetic...prettygully
Approximate lower bound sampling errors of maximum likelihood estimates of covariance components and their linear functions can be obtained from the inverse of the
information matrix. For non-linear functions, sampling variances are commonly determined as the variance of their first order Taylor series expansions. This is used to obtain sampling errors for estimates of heritabilities and correlations, and these quantities can be computed
with most software performing such analyses. In other instances, however, more complicated functions are of interest or the linear approximation is difficult or inadequate. A pragmatic alternative then is to evaluate sampling characteristics by repeated sampling of parameters from their asymptotic, multivariate normal distribution, calculating the function(s) of interest for each sample and inspecting the distribution across replicates. This paper demonstrates the use of this approach and examines the quality of
approximation obtained.
The document outlines the details of a proposed new monthly British music magazine, including:
- It will focus on influential British bands from previous eras like Pulp, The Beatles, and Queen.
- The target price point is £4.95 per monthly issue to appeal to collectors.
- The magazine will have a contemporary feel while also featuring bands inspired by the artists profiled.
OBJECTIVE: To merge into a dynamic organization as IT Professional in the field of Software Quality Testing that will strategically utilize my existing skill sets while providing opportunities to amalgamate personal enrichment with professional goals
This short document promotes creating presentations on SlideShare using Haiku Deck. It includes photos from stock photo sites to illustrate the point and encourages the reader to get started making their own Haiku Deck presentation on SlideShare.
The heart is a muscular organ about the size of a closed fist located in the thoracic cavity. It has three layers: an outer epicardium, middle myocardium that is made of cardiac muscle, and inner endocardium. The heart pumps deoxygenated blood to the lungs and oxygenated blood throughout the body in two circuits - the pulmonary and systemic circuits. Blood flows through the heart in one direction, entering the right atrium and exiting the left ventricle, driven by cardiac muscle and prevented from backflow by valves.
The document welcomes readers to an art show featuring K-12 student artwork from the Batavia City School District. The show is being held at the Richmond Library in March 2014 and thanks the student artists for sharing their work with the local community in Genesee County.
Sampling based approximation of confidence intervals for functions of genetic...prettygully
Approximate lower bound sampling errors of maximum likelihood estimates of covariance components and their linear functions can be obtained from the inverse of the
information matrix. For non-linear functions, sampling variances are commonly determined as the variance of their first order Taylor series expansions. This is used to obtain sampling errors for estimates of heritabilities and correlations, and these quantities can be computed
with most software performing such analyses. In other instances, however, more complicated functions are of interest or the linear approximation is difficult or inadequate. A pragmatic alternative then is to evaluate sampling characteristics by repeated sampling of parameters from their asymptotic, multivariate normal distribution, calculating the function(s) of interest for each sample and inspecting the distribution across replicates. This paper demonstrates the use of this approach and examines the quality of
approximation obtained.
The document outlines the details of a proposed new monthly British music magazine, including:
- It will focus on influential British bands from previous eras like Pulp, The Beatles, and Queen.
- The target price point is £4.95 per monthly issue to appeal to collectors.
- The magazine will have a contemporary feel while also featuring bands inspired by the artists profiled.
OBJECTIVE: To merge into a dynamic organization as IT Professional in the field of Software Quality Testing that will strategically utilize my existing skill sets while providing opportunities to amalgamate personal enrichment with professional goals
This short document promotes creating presentations on SlideShare using Haiku Deck. It includes photos from stock photo sites to illustrate the point and encourages the reader to get started making their own Haiku Deck presentation on SlideShare.
The heart is a muscular organ about the size of a closed fist located in the thoracic cavity. It has three layers: an outer epicardium, middle myocardium that is made of cardiac muscle, and inner endocardium. The heart pumps deoxygenated blood to the lungs and oxygenated blood throughout the body in two circuits - the pulmonary and systemic circuits. Blood flows through the heart in one direction, entering the right atrium and exiting the left ventricle, driven by cardiac muscle and prevented from backflow by valves.
The document welcomes readers to an art show featuring K-12 student artwork from the Batavia City School District. The show is being held at the Richmond Library in March 2014 and thanks the student artists for sharing their work with the local community in Genesee County.