Early diagnosis of IEM is a challenge for pediatricians since they will not present any symptoms in the new-born period. Most of the IEM cases are diagnosed after a few months or even after a few years of birth and by this time life threatening irreversible damage to the brain or other disability has already happened. Dr Sujit Chatterjee, CEO of Hiranandani Hospital Kidney Transplant highlights “NBS test as the name suggest is a group of tests done within three days of birth to screen for diseases that may be sub-clinical and have long term implications on quality of life.