This document provides an overview of muscle tissue histophysiology. It discusses the structural unit of muscle tissue as muscle fibers. It describes the organization of skeletal muscles into myofibrils, sarcomeres, and myofilaments. It explains the sliding filament theory of muscle contraction and how calcium targets activate myofilament sliding. It also discusses dystrophin's role in muscle fiber stability and protection from contraction damage. Smooth muscle tissue types and their roles in organs like the GI tract and blood vessels are outlined. The molecular organization of filaments and caveolae structures in smooth muscle are briefly touched on.

1. Histophysiology of muscle
tissues

3. The structural unit of muscle
tissue is muscle fibre

7. Muscle as organ

9. Skeletal muscles

11. Myofibril

12. Myofibril

13. Sarcomere

14. Myofilamentes

16. Mechanism of contraction
http://www.youtube.com/watch?v=ELyoJZom5N0

17. Myofilaments sliding theory

18. Targets of calcium

19. Look inside

20. T- and L-systems

21. Look inside

22. Filaments arrangement
http://www.mechanobio.info/Home/essential-info/What-are-Motor-Proteins/myosin-role-in-contraction

23. Dystrophin Dystrophin stabilizes the
sarcolemma and protects
muscle fibres from long-term
contraction-induced damage
and necrosis.
Dystrophin serves to link the
intracellular microfilament
network of actin to a complex
series of linking proteins in the
cell membrane, and hence to
the extracellular matrix

24. How to get energy during
contraction

25. Fitness

26. Physical training and ANS

27. Physical training and resistence
to stress
Physical
training

28. Will be discussed during circulatory system
lecture

29. Smooth muscle tissue

30. Significance of smooth
myocytes
Gastro-Intestinal smooth myocytes:
- Contractile type - Tone of gut, gut motility
- pacemaker (Interstitial cells of Cajal) – tone control, generation of electrical
slow waves

31. Significance of smooth
myocytes
Vascular smooth myocytes:
-Tcontractile type - tone of vessel – resistence – blood pressure
- secretory rype – matrix production

32. Types of smooth myocytes

33. News about smooth muscles
miRNA-mediated SMC remodelling

34. Contraction of of smooth
myocyte

35. Filamentes arrangement in smooth
myocyte

36. Molecular organisation of
filaments in smooth myocyte

38. Caveolae of smooth myocyte

39. Caveolae nature

40. Caveolae significance

41. Regulation of smooth
myocytes
Neural
Paracrine
Humoral

42. Diagnostics