This document summarizes the role of white blood cells (leukocytes) in the immune system. It discusses the different types of leukocytes produced in the bone marrow and lymphatic tissues, including granulocytes, monocytes, lymphocytes, and their functions. It describes how leukocytes are transported through the body, engage in processes like chemotaxis, phagocytosis, and inflammation to fight pathogens. The lifespan and responses of different white blood cells are also covered, along with their importance in the immune response and forming pus to isolate infections.
This document discusses various types of bone marrow failure syndromes including aplastic anemia, Fanconi anemia, pure red cell aplasia, myelophthisic anemia, and polycythemia. Aplastic anemia is a syndrome of chronic primary hematopoietic failure caused by a stem cell defect that results in pancytopenia. Fanconi anemia is an inherited disorder characterized by bone marrow hypoplasia and physical abnormalities. Pure red cell aplasia is a primary marrow disorder where only erythroid progenitors are suppressed. Myelophthisic anemia occurs when solid tumors destroy bone marrow architecture. Polycythemia is a myeloproliferative disorder resulting in increased red blood
This document summarizes diseases of white blood cells and lymphoid tissue. It discusses topics like leukopenia, leukocytosis, lymphoma, leukemia, and myeloproliferative disorders. Specific conditions covered include chronic myelogenous leukemia, polycythemia vera, essential thrombocytosis, multiple myeloma, acute and chronic lymphocytic leukemias. The document reviews normal white blood cell development and function, as well as abnormalities, classifications, symptoms, and characteristics of various malignant proliferations of white blood cells and lymphocytes.
POWERPOINT PRESENTATION ON WHITE BLOOD CELLSVidya P Pillai
The document discusses the different types of white blood cells (leukocytes). There are two main types: granulocytes which contain granules in their cytoplasm, and agranulocytes which do not contain granules. The granulocytes - neutrophils, eosinophils, and basophils - make up the majority of white blood cells and function to phagocytose foreign materials. The agranulocytes, lymphocytes and monocytes, have clear cytoplasm and play important roles in fighting viruses, tumors, and bacteria.
White Blood Cell Disorders can affect neutrophils, eosinophils, basophils and mast cells. Neutropenia is classified by severity based on absolute neutrophil count and risk of infection. Causes include acquired conditions like drugs/infections or congenital disorders. Hypereosinophilic syndrome is a broad condition caused by primary or secondary eosinophilia leading to tissue damage. Diagnosis involves ruling out secondary causes and identifying organ involvement. Treatment depends on etiology and includes steroids, hydroxyurea, interferon-alpha, imatinib or anti-IL-5 antibodies.
White blood cells can be categorized as either granular leukocytes, which contain granules in their cytoplasm and are formed in the bone marrow, or agranular leukocytes, which lack granules and are formed in lymph nodes, spleen, tonsils, and thymus. Phagocytes are granular white blood cells with lobed nuclei that ingest and digest foreign particles like bacteria through phagocytosis in the bone marrow. Lymphocytes are agranular white blood cells with spherical nuclei that secrete antibodies to target specific pathogens and provide immunity.
anemia & other blood disease and its manifestations in oral cavityGazwan Faisal
This document discusses several blood diseases including bleeding disorders, platelet deficiencies, and red and white blood cell disorders. It provides details on the clinical features of these diseases such as oral bleeding, bruising, infections, and ulcerations. Specific disorders covered include anemia, leukopenia, thrombocytopenia, and leukemia. The roles of platelets, coagulation factors, and blood cells are explained. Treatment considerations for patients with blood diseases, such as avoiding certain medications, are also summarized.
This document summarizes the role of white blood cells (leukocytes) in the immune system. It discusses the different types of leukocytes produced in the bone marrow and lymphatic tissues, including granulocytes, monocytes, lymphocytes, and their functions. It describes how leukocytes are transported through the body, engage in processes like chemotaxis, phagocytosis, and inflammation to fight pathogens. The lifespan and responses of different white blood cells are also covered, along with their importance in the immune response and forming pus to isolate infections.
This document discusses various types of bone marrow failure syndromes including aplastic anemia, Fanconi anemia, pure red cell aplasia, myelophthisic anemia, and polycythemia. Aplastic anemia is a syndrome of chronic primary hematopoietic failure caused by a stem cell defect that results in pancytopenia. Fanconi anemia is an inherited disorder characterized by bone marrow hypoplasia and physical abnormalities. Pure red cell aplasia is a primary marrow disorder where only erythroid progenitors are suppressed. Myelophthisic anemia occurs when solid tumors destroy bone marrow architecture. Polycythemia is a myeloproliferative disorder resulting in increased red blood
This document summarizes diseases of white blood cells and lymphoid tissue. It discusses topics like leukopenia, leukocytosis, lymphoma, leukemia, and myeloproliferative disorders. Specific conditions covered include chronic myelogenous leukemia, polycythemia vera, essential thrombocytosis, multiple myeloma, acute and chronic lymphocytic leukemias. The document reviews normal white blood cell development and function, as well as abnormalities, classifications, symptoms, and characteristics of various malignant proliferations of white blood cells and lymphocytes.
POWERPOINT PRESENTATION ON WHITE BLOOD CELLSVidya P Pillai
The document discusses the different types of white blood cells (leukocytes). There are two main types: granulocytes which contain granules in their cytoplasm, and agranulocytes which do not contain granules. The granulocytes - neutrophils, eosinophils, and basophils - make up the majority of white blood cells and function to phagocytose foreign materials. The agranulocytes, lymphocytes and monocytes, have clear cytoplasm and play important roles in fighting viruses, tumors, and bacteria.
White Blood Cell Disorders can affect neutrophils, eosinophils, basophils and mast cells. Neutropenia is classified by severity based on absolute neutrophil count and risk of infection. Causes include acquired conditions like drugs/infections or congenital disorders. Hypereosinophilic syndrome is a broad condition caused by primary or secondary eosinophilia leading to tissue damage. Diagnosis involves ruling out secondary causes and identifying organ involvement. Treatment depends on etiology and includes steroids, hydroxyurea, interferon-alpha, imatinib or anti-IL-5 antibodies.
White blood cells can be categorized as either granular leukocytes, which contain granules in their cytoplasm and are formed in the bone marrow, or agranular leukocytes, which lack granules and are formed in lymph nodes, spleen, tonsils, and thymus. Phagocytes are granular white blood cells with lobed nuclei that ingest and digest foreign particles like bacteria through phagocytosis in the bone marrow. Lymphocytes are agranular white blood cells with spherical nuclei that secrete antibodies to target specific pathogens and provide immunity.
anemia & other blood disease and its manifestations in oral cavityGazwan Faisal
This document discusses several blood diseases including bleeding disorders, platelet deficiencies, and red and white blood cell disorders. It provides details on the clinical features of these diseases such as oral bleeding, bruising, infections, and ulcerations. Specific disorders covered include anemia, leukopenia, thrombocytopenia, and leukemia. The roles of platelets, coagulation factors, and blood cells are explained. Treatment considerations for patients with blood diseases, such as avoiding certain medications, are also summarized.
India wellness industry outlook 2016 robust growth in alternativeRose088
The document provides information on a report titled "India Wellness Industry Outlook 2016 – Robust Growth in Alternative Therapy and Nutraceuticals Market". The 123-page report can be purchased for $900 in PDF format, $1200 in hard copy format, or $1650 for an enterprise license. It provides an analysis of the Indian wellness industry market size and segmentation, including categories like fitness, spa services, alternative therapies, cosmetics, and nutraceuticals. The wellness industry in India grew by 16.9% in 2011, particularly among urban residents aged 25-49. The report also covers industry trends, projections, and the market for specific segments like fitness and slimming.
India waste management and recycling market outlook to 2016Rose088
The document summarizes a report on the India Waste Management and Recycling Market Outlook from 2006-2016. The 110-page report provides an analysis of the waste industry in India, focusing on municipal solid waste, industrial hazardous waste, e-waste, and bio medical waste. It details the market size and segmentation of the waste management sector in India. Key topics covered include market sizes and projections, regulations, trends, and the competitive landscape of major players. The report analyzes factors influencing industry growth and provides future projections for waste industry segments in India.
The document discusses a report on the pipeline of treatments for Hereditary Angioedema (HAE), including 82 pages on products in development from discovery to registration, with details on companies and universities involved, 20% discounts on reports over $1000, and contact information for sample reports or questions.
The document summarizes a report on the global pipeline of treatments for congestive heart failure (CHF) in the second half of 2012. The 290-page report provides an overview of CHF and treatments currently in development, including those in late stages of testing. It profiles key companies and universities researching new CHF therapies and analyzes products at different stages of development. The report aims to help identify emerging treatments and players to inform strategic decision-making around mergers, acquisitions and competitive strategies. It is available for purchase at prices ranging from $2000 to $6000 depending on the license. Contact information is provided to request a sample or related reports on other drug pipelines.
This document summarizes a 106-page report on the pipeline of therapeutics under development for acute renal failure (ARF)/acute kidney injury. The report provides an overview of the therapeutic pipeline as of the second half of 2012, including details on late-stage, mid-clinical stage, early clinical stage, and pre-clinical products. It reviews key players and universities involved in developing treatments for ARF/acute kidney injury and allows identification of emerging companies. The report can be purchased for various license fees or a sample may be requested.
Downstream processing in biopharmaceuticals adoptionRose088
This document summarizes a report from GBI Research about downstream processing in biopharmaceuticals. It discusses the adoption of disposable technologies at larger economies of scale to optimize production efficiency and cost-effectiveness. The report provides an overview of the biopharmaceutical and contract manufacturing industries as well as the downstream processing and reagent markets. It also includes market data, forecasts, profiles of key players, and an analysis of drivers and restraints. The report aims to help readers develop market strategies and understand factors shaping the industries.
This document summarizes a market research report on the pipeline of therapies for amyloidosis. The report provides an overview of therapeutic candidates in development for amyloidosis, including their current stage of development. It analyzes pipeline products by company and university, and profiles major companies involved in developing treatments for this condition, such as GlaxoSmithKline, Isis Pharmaceuticals, and Alnylam Pharmaceuticals. Sample pages of the report can be requested by email for review.
This document summarizes a market research report from Global Markets Direct about Incyte Corporation's product pipeline as of 2012. It provides an overview of Incyte's research areas and pipeline of drug candidates, including those in late-stage development and clinical trials. Key information is given about Incyte's business and locations. The full report contains additional details on pipeline candidates like mechanisms of action, development progress updates, and discontinued projects. It also includes tables, figures and references to related reports available from the publisher.
The document summarizes a market research report on the Chinese markets for industrial lubricants. It examines China's economic trends, industry development, supply and demand for industrial lubricants in China. The report provides historical data from 2001 to 2011 and forecasts through 2016 and 2021. It profiles major lubricant producers in China and analyzes the industrial lubricants industry capacity, market share, technology development and major end-users. The full report is available for 50% off at $2000 and contains sections on business environment, industry assessments, and production and demand for various industrial lubricants.
This document summarizes a book about national security in Mumbai. It includes 18 chapters covering various sectors like transport, power, telecom, and others. It discusses security requirements and challenges for each sector. The book aims to assess the implications of security technologies and develop an effective system to address emerging threats. It also includes security requirements for Indian states, union territories, and some other countries.
This document summarizes a market research report on the product pipeline of Zydus Cadila Healthcare Limited. The report provides details on Zydus Cadila's research areas and developmental pipeline, including current projects in various stages of development across different therapy areas. It also lists several of Zydus Cadila's pipeline candidates, including their descriptions and development progress. Contact information is provided for requesting a sample of the full market research report.
Ziopharm oncology, inc. – product pipeline review – 2012Rose088
The document summarizes a market research report on ZIOPHARM Oncology, Inc.'s product pipeline as of 2012. It provides an overview of ZIOPHARM's research areas and developmental pipeline, including projects in various stages of development across different therapy areas. The report also includes snapshots of key pipeline candidates such as Ad-IL-12 and DC-IL-12, along with their descriptions, mechanisms of action, and research progress. Tables of contents and figures from the full report are listed as well.
Topo target a s – product pipeline review – 2012Rose088
The document summarizes a market research report from Global Markets Direct about the product pipeline of TopoTarget A/S, a pharmaceutical company. The report provides details on TopoTarget's current developmental pipeline, including projects in clinical trials and pre-clinical research across various therapy areas. It also profiles several of TopoTarget's key pipeline drugs and combination treatment modalities in development, including their descriptions, mechanisms of action, and research progress. Contact information is provided to request a sample of the full report or for questions.
Macro genics, inc. – product pipeline review – 2012Rose088
This document summarizes a market research report about MacroGenics, Inc.'s product pipeline as of 2012. It provides an overview of MacroGenics' research areas, pipeline of products in development across various therapy areas and stages of the drug development process. It also includes brief profiles of some of MacroGenics' key pipeline products in development, such as DART for autoimmune disorders, DART mAbs, and monoclonal antibodies. The full report contains additional details on MacroGenics' pipeline like lists of tables and figures as well as related reports that can be purchased.
Ym bio sciences inc. – product pipeline review – 2012Rose088
This document summarizes a market research report on YM BioSciences Inc.'s product pipeline as of 2012. It provides an overview of YM BioSciences' business and focus on key therapeutic areas. The report also details YM's pipeline of candidates in various stages of clinical development, including Phase III, Phase II and Phase I trials, as well as combination treatment modalities. It profiles several of YM's lead pipeline candidates and outlines their mechanisms of action and development progress. Contact information is provided to request a sample of the full report or for additional related pharmaceutical reports.
The document announces the availability of a market research report on the Astrocytoma therapeutic pipeline from Global Markets Direct. The report provides an overview and details on drug candidates in development for Astrocytoma, including those from companies and universities. It covers products from discovery to registration stages and key players involved. Sample pages of the report can be requested by email.
Ipsen inc. – product pipeline review – 2012Rose088
This document summarizes a market research report on Ipsen Inc.'s product pipeline in 2012. The report provides an overview of Ipsen's research areas and pipeline of drugs in development, including those in Phase III clinical trials. It also lists Ipsen's locations and subsidiaries. The document encourages requesting a sample of the full market research report or searching for similar reports on pharmaceutical pipelines and healthcare topics through the Aarkstore website.
This document summarizes a market research report on MethylGene Inc's product pipeline as of 2012. The report provides details on MethylGene's research areas and pipeline of drug candidates at various stages of clinical trials. It describes several of MethylGene's lead drug candidates, including their mechanisms of action and development progress. Tables of contents and figures are included listing the report's contents. Contact information is provided to request a sample or purchase the full report.
This document summarizes a market research report on MerLion Pharmaceuticals Pte Ltd's product pipeline as of 2012. The report provides an overview of MerLion's research areas and developmental pipeline, including both current and discontinued/dormant projects. It describes the various stages of drug development for molecules across MerLion's portfolio in therapeutic areas such as anti-virulence, antibiotics, and anti-fungals. Tables and figures in the report provide additional details on MerLion's clinical and early-stage pipeline products. Contact information is provided for inquiries about purchasing the full report.
This document summarizes a market research report on Glenmark Pharmaceuticals Ltd's product pipeline as of 2012. The report provides details on Glenmark's research areas and pipeline of drug candidates at various stages of development, including 4 drugs in late-stage Phase III trials and several others in early-stage pre-clinical testing. Tables of contents and figures are included listing the pipeline drugs and studies. Contact information is provided to request a sample or related reports on pharmaceutical company pipelines and products.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
India wellness industry outlook 2016 robust growth in alternativeRose088
The document provides information on a report titled "India Wellness Industry Outlook 2016 – Robust Growth in Alternative Therapy and Nutraceuticals Market". The 123-page report can be purchased for $900 in PDF format, $1200 in hard copy format, or $1650 for an enterprise license. It provides an analysis of the Indian wellness industry market size and segmentation, including categories like fitness, spa services, alternative therapies, cosmetics, and nutraceuticals. The wellness industry in India grew by 16.9% in 2011, particularly among urban residents aged 25-49. The report also covers industry trends, projections, and the market for specific segments like fitness and slimming.
India waste management and recycling market outlook to 2016Rose088
The document summarizes a report on the India Waste Management and Recycling Market Outlook from 2006-2016. The 110-page report provides an analysis of the waste industry in India, focusing on municipal solid waste, industrial hazardous waste, e-waste, and bio medical waste. It details the market size and segmentation of the waste management sector in India. Key topics covered include market sizes and projections, regulations, trends, and the competitive landscape of major players. The report analyzes factors influencing industry growth and provides future projections for waste industry segments in India.
The document discusses a report on the pipeline of treatments for Hereditary Angioedema (HAE), including 82 pages on products in development from discovery to registration, with details on companies and universities involved, 20% discounts on reports over $1000, and contact information for sample reports or questions.
The document summarizes a report on the global pipeline of treatments for congestive heart failure (CHF) in the second half of 2012. The 290-page report provides an overview of CHF and treatments currently in development, including those in late stages of testing. It profiles key companies and universities researching new CHF therapies and analyzes products at different stages of development. The report aims to help identify emerging treatments and players to inform strategic decision-making around mergers, acquisitions and competitive strategies. It is available for purchase at prices ranging from $2000 to $6000 depending on the license. Contact information is provided to request a sample or related reports on other drug pipelines.
This document summarizes a 106-page report on the pipeline of therapeutics under development for acute renal failure (ARF)/acute kidney injury. The report provides an overview of the therapeutic pipeline as of the second half of 2012, including details on late-stage, mid-clinical stage, early clinical stage, and pre-clinical products. It reviews key players and universities involved in developing treatments for ARF/acute kidney injury and allows identification of emerging companies. The report can be purchased for various license fees or a sample may be requested.
Downstream processing in biopharmaceuticals adoptionRose088
This document summarizes a report from GBI Research about downstream processing in biopharmaceuticals. It discusses the adoption of disposable technologies at larger economies of scale to optimize production efficiency and cost-effectiveness. The report provides an overview of the biopharmaceutical and contract manufacturing industries as well as the downstream processing and reagent markets. It also includes market data, forecasts, profiles of key players, and an analysis of drivers and restraints. The report aims to help readers develop market strategies and understand factors shaping the industries.
This document summarizes a market research report on the pipeline of therapies for amyloidosis. The report provides an overview of therapeutic candidates in development for amyloidosis, including their current stage of development. It analyzes pipeline products by company and university, and profiles major companies involved in developing treatments for this condition, such as GlaxoSmithKline, Isis Pharmaceuticals, and Alnylam Pharmaceuticals. Sample pages of the report can be requested by email for review.
This document summarizes a market research report from Global Markets Direct about Incyte Corporation's product pipeline as of 2012. It provides an overview of Incyte's research areas and pipeline of drug candidates, including those in late-stage development and clinical trials. Key information is given about Incyte's business and locations. The full report contains additional details on pipeline candidates like mechanisms of action, development progress updates, and discontinued projects. It also includes tables, figures and references to related reports available from the publisher.
The document summarizes a market research report on the Chinese markets for industrial lubricants. It examines China's economic trends, industry development, supply and demand for industrial lubricants in China. The report provides historical data from 2001 to 2011 and forecasts through 2016 and 2021. It profiles major lubricant producers in China and analyzes the industrial lubricants industry capacity, market share, technology development and major end-users. The full report is available for 50% off at $2000 and contains sections on business environment, industry assessments, and production and demand for various industrial lubricants.
This document summarizes a book about national security in Mumbai. It includes 18 chapters covering various sectors like transport, power, telecom, and others. It discusses security requirements and challenges for each sector. The book aims to assess the implications of security technologies and develop an effective system to address emerging threats. It also includes security requirements for Indian states, union territories, and some other countries.
This document summarizes a market research report on the product pipeline of Zydus Cadila Healthcare Limited. The report provides details on Zydus Cadila's research areas and developmental pipeline, including current projects in various stages of development across different therapy areas. It also lists several of Zydus Cadila's pipeline candidates, including their descriptions and development progress. Contact information is provided for requesting a sample of the full market research report.
Ziopharm oncology, inc. – product pipeline review – 2012Rose088
The document summarizes a market research report on ZIOPHARM Oncology, Inc.'s product pipeline as of 2012. It provides an overview of ZIOPHARM's research areas and developmental pipeline, including projects in various stages of development across different therapy areas. The report also includes snapshots of key pipeline candidates such as Ad-IL-12 and DC-IL-12, along with their descriptions, mechanisms of action, and research progress. Tables of contents and figures from the full report are listed as well.
Topo target a s – product pipeline review – 2012Rose088
The document summarizes a market research report from Global Markets Direct about the product pipeline of TopoTarget A/S, a pharmaceutical company. The report provides details on TopoTarget's current developmental pipeline, including projects in clinical trials and pre-clinical research across various therapy areas. It also profiles several of TopoTarget's key pipeline drugs and combination treatment modalities in development, including their descriptions, mechanisms of action, and research progress. Contact information is provided to request a sample of the full report or for questions.
Macro genics, inc. – product pipeline review – 2012Rose088
This document summarizes a market research report about MacroGenics, Inc.'s product pipeline as of 2012. It provides an overview of MacroGenics' research areas, pipeline of products in development across various therapy areas and stages of the drug development process. It also includes brief profiles of some of MacroGenics' key pipeline products in development, such as DART for autoimmune disorders, DART mAbs, and monoclonal antibodies. The full report contains additional details on MacroGenics' pipeline like lists of tables and figures as well as related reports that can be purchased.
Ym bio sciences inc. – product pipeline review – 2012Rose088
This document summarizes a market research report on YM BioSciences Inc.'s product pipeline as of 2012. It provides an overview of YM BioSciences' business and focus on key therapeutic areas. The report also details YM's pipeline of candidates in various stages of clinical development, including Phase III, Phase II and Phase I trials, as well as combination treatment modalities. It profiles several of YM's lead pipeline candidates and outlines their mechanisms of action and development progress. Contact information is provided to request a sample of the full report or for additional related pharmaceutical reports.
The document announces the availability of a market research report on the Astrocytoma therapeutic pipeline from Global Markets Direct. The report provides an overview and details on drug candidates in development for Astrocytoma, including those from companies and universities. It covers products from discovery to registration stages and key players involved. Sample pages of the report can be requested by email.
Ipsen inc. – product pipeline review – 2012Rose088
This document summarizes a market research report on Ipsen Inc.'s product pipeline in 2012. The report provides an overview of Ipsen's research areas and pipeline of drugs in development, including those in Phase III clinical trials. It also lists Ipsen's locations and subsidiaries. The document encourages requesting a sample of the full market research report or searching for similar reports on pharmaceutical pipelines and healthcare topics through the Aarkstore website.
This document summarizes a market research report on MethylGene Inc's product pipeline as of 2012. The report provides details on MethylGene's research areas and pipeline of drug candidates at various stages of clinical trials. It describes several of MethylGene's lead drug candidates, including their mechanisms of action and development progress. Tables of contents and figures are included listing the report's contents. Contact information is provided to request a sample or purchase the full report.
This document summarizes a market research report on MerLion Pharmaceuticals Pte Ltd's product pipeline as of 2012. The report provides an overview of MerLion's research areas and developmental pipeline, including both current and discontinued/dormant projects. It describes the various stages of drug development for molecules across MerLion's portfolio in therapeutic areas such as anti-virulence, antibiotics, and anti-fungals. Tables and figures in the report provide additional details on MerLion's clinical and early-stage pipeline products. Contact information is provided for inquiries about purchasing the full report.
This document summarizes a market research report on Glenmark Pharmaceuticals Ltd's product pipeline as of 2012. The report provides details on Glenmark's research areas and pipeline of drug candidates at various stages of development, including 4 drugs in late-stage Phase III trials and several others in early-stage pre-clinical testing. Tables of contents and figures are included listing the pipeline drugs and studies. Contact information is provided to request a sample or related reports on pharmaceutical company pipelines and products.
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
Milan J. Anadkat, MD, and Dale V. Reisner discuss generalized pustular psoriasis in this CME activity titled "Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communications Strategies to Improve Shared Decision-Making." For the full presentation, please visit us at www.peervoice.com/HUM870.
Applications of NMR in Protein Structure Prediction.pptxAnagha R Anil
This presentation explores the pivotal role of Nuclear Magnetic Resonance (NMR) spectroscopy in predicting protein structures. It delves into the methodologies, advancements, and applications of NMR in determining the three-dimensional configurations of proteins, which is crucial for understanding their function and interactions.
Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)MuskanShingari
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
1. Leukocyte Disorders (White Blood Cell Disorders) –
Pipeline Review, H2 2012
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Summary
Global Markets Direct’s, Leukocyte Disorders (White Blood Cell Disorders) - Pipeline
Review, H2 2012, provides an overview of the Leukocyte Disorders (White Blood
Cell Disorders) therapeutic pipeline. This report provides information on the
therapeutic development for Leukocyte Disorders (White Blood Cell Disorders),
complete with latest updates, and special features on late-stage and discontinued
projects. It also reviews key players involved in the therapeutic development for
Leukocyte Disorders (White Blood Cell Disorders). Leukocyte Disorders (White
Blood Cell Disorders) - Pipeline Review, H2 2012 is built using data and information
sourced from Global Markets Direct’s proprietary databases, Company/University
websites, SEC filings, investor presentations and featured press releases from
company/university sites and industry-specific third party sources, put together by
Global Markets Direct’s team.
Note*: Certain sections in the report may be removed or altered based on the
availability and relevance of data for the indicated disease.
Scope
- A snapshot of the global therapeutic scenario for Leukocyte Disorders (White
Blood Cell Disorders).
- A review of the Leukocyte Disorders (White Blood Cell Disorders) products under
development by companies and universities/research institutes based on
2. Leukocyte Disorders (White Blood Cell Disorders) –
Pipeline Review, H2 2012
information derived from company and industry-specific sources.
- Coverage of products based on various stages of development ranging from
discovery till registration stages.
Table of contents:
List of Tables 4
List of Figures 5
Introduction 6
Global Markets Direct Report Coverage 6
Leukocyte Disorders (White Blood Cell Disorders) Overview 7
Therapeutics Development 8
An Overview of Pipeline Products for Leukocyte Disorders (White Blood Cell
Disorders) 8
Leukocyte Disorders (White Blood Cell Disorders) Therapeutics under Development
by Companies 10
Leukocyte Disorders (White Blood Cell Disorders) Therapeutics under Investigation
by Universities/Institutes 13
Late Stage Products 16
Comparative Analysis 16
Mid Clinical Stage Products 17
Comparative Analysis 17
Early Clinical Stage Products 18
Comparative Analysis 18
Discovery and Pre-Clinical Stage Products 19
Comparative Analysis 19
Leukocyte Disorders (White Blood Cell Disorders) Therapeutics – Products under
Development by Companies 20
Leukocyte Disorders (White Blood Cell Disorders) Therapeutics – Products under
Investigation by Universities/Institutes 22
Companies Involved in Leukocyte Disorders (White Blood Cell Disorders)
Therapeutics Development 24
Kyowa Hakko Kirin Co., Ltd. 24
GlaxoSmithKline plc 25
Gamida Cell Ltd. 26
Mochida Pharmaceutical Co., Ltd. 27
3. Leukocyte Disorders (White Blood Cell Disorders) –
Pipeline Review, H2 2012
STADA Arzneimittel AG 28
Taiho Pharmaceutical Co., Ltd. 29
Ligand Pharmaceuticals Incorporated 30
Lupin Limited 31
NexMed, Inc. 32
Telik, Inc. 33
Zenotech Laboratories Limited 34
ProMetic Life Sciences Inc. 35
Lipoxen PLC 36
Green Cross Corporation 37
Bolder Biotechnology, Inc. 38
Welichem Biotech Inc. 39
PharmaEssentia Corporation 40
ImmuneRegen BioSciences, Inc. 41
Pfenex Inc. 42
Leukocyte Disorders (White Blood Cell Disorders) – Therapeutics Assessment 43
Assessment by Monotherapy Products 43
Assessment by Combination Products 44
Assessment by Route of Administration 45
Assessment by Molecule Type 47
Drug Profiles 50
Homspera - Drug Profile 50
List of Figures
List of Tables are also include.
For more related Reports Plz follow The link:
Pipeline Review, H2 2012
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