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Author Year Patients 30d Results FUP
Parallel grafts death
stroke
and/or
paraplegia
EL reintervention reintervention survival
Mangialardi 2014 26 1 2 6 3 - 80%@3years
Vicente 2014 1 0 0 0 0 0 100%@0.8years
Synoviecz 2013 1 0 0 0 0 0 -
Shahverdyan 2013 6 1 0 3 2 1 83%@0.2years
Samura 2013 2 0 0 2 0 0 100%@0.5years
Zhu 2013 34 0 0 2 4 4 94%@1year
Chang 2013 1 0 0 0 0 0 100%@1year
Zhou 2013 1 0 0 2 0 0 100%@1year
Vallejo 2012 8 1 1 0 3 5 -
Akchurin 2012 10 0 0 1 0 0 100%@0.5years
Cires 2011 9 1 1 0 1 3 100%@0.4years
Yoshida 2011 2 0 0 2 0 1 -
Shu 2011 8 0 0 0 0 0 100%@1year
Feng 2011 1 0 0 0 0 0 100%@1year
Gehringhoff 2011 9 1 0 1 0 1 79%@1year
Sugiura 2009 11 2 1 2 0 1 -
Baldwin 2008 7 0 1 1 0 0 -
Ohrlander 2008 4 0 0 2 1 2
Criado 2007 8 0 0 0 0 0 -
Hiramoto 2006 1 0 0 0 0 0 -
Larzon 2005 2 0 0 2 0 0 -
Total 152 7 6 26 14 18
% 5 4 17 9 12 “94%”@”1year”
Author Year Patients 30d Results FUP
Conventional Open Repair death
stroke
and/or
paraplegia
EL reintervention reintervention survival
Andersen 2012 20 2 1 - 3 0 51@5y
Baraki 2007 39 5 5 - 0 3 87@1.9Y
Chen 2010 28 4 6 - 1 0 88%@5y
Di eusanio 2013 122 21 20 - 15 0 97%@1y
Flores 2006 25 3 8 - - - -
Hofferberth 2012 19 1 3 - 0 4 -
Hoffmann 2012 32 1 1 - 4 0 -
Ius 2013 131 20 15 - 24 0 72%@5y
Jakob 2011 270 41 35 - 38 0 74%@5y
Jim 2011 10 1 1 2 0 1 50%@3Y
Kawaharada 2009 31 2 1 1 0 4 73%@5Y
Lee 2011 21 4 3 2 0 5 -
Leontyev 2013 46 4 11 - 6 0 68%@5y
Lima 2012 50 4 6 1 2 0 87%@2Y
Nishi 2011 61 2 6 - 0 3 -
Pochettino 2009 36 5 1 - - - -
Roselli 2013 17 0 2 - - - -
Shen 2012 38 3 2 - - - 91%@5y
Shi 2011 46 1 1 - 2 0 -
Shimamura 2008 126 4 11 - 3 0 63%@5y
Shimamura 2009 69 5 6 6 2 6 89%@3Y
Shrestha 2012 34 3 1 - 6 2 -
Sun 2013 398 31 20 - 28 0 -
Uchida 2011 80 3 7 - 2 0 -
Usui 2002 24 0 4 - - - 96%@1year
Xiao 2013 33 6 0 0 - - -
Zhao 2012 24 1 1 1 0 1 92%@5Y
Total 1830 176 180 13 135 29
% 10 10 5,5 8 1,8 “79%”@”4years”
Author Year Device Patients 30d Results FUP
F/BEVAR death
stroke
and/or
paraplegia
EL reintervention reintervention survival
Inoue K 1999 BEVAR-Inoue 15 0 1 4 1 4 87%@1year
McWilliams 2004 FEVAR 1 0 0 0 0 0 100%@0.5Year
Saito N 2005 BEVAR-Inoue 17 0 1 3 0 2 88%@2.2years
Chuter T 2003 BEVAR 1 0 0 0 0 0 -
Brar R 2008 BEVAR 1 0 0 0 0 0 -
Kawaguchi 2008 FEVAR 288 - 16 - - - 62%@5years
Sonesson 2009 FEVAR 1 0 0 0 0 - 100%@0.1Year
Manning 2010 FEVAR 10 0 0 0 0 0 -
Yusa 2011 FEVAR 10 0 0 1 0 0 -
Lioupis 2012 BEVAR 6 0 2 2 1 0 -
Spear 2013 BEVAR 1 0 0 0 0 - -
Azuma 2013 FEVAR 393 6 10 12 - - -
Haulon 2014 BEVAR 38 5 6 4 3 -
Anderson 2015 FEVAR 2 0 0 0 0 0 100%@0.5 years
Matsuyama 2015 FEVAR 37 1 2 1 0 11 65%@5years
Mangialardi 2015
FEAVR-
Najuta
1 0 0 0 0 0 -
Tse 2015 FEVAR-insitu 6 0 1 0 0 0 -
Kurimoto 2015 FEVAR 37 0 5 12 0 4 86%@2years
Total 865 12 44 35 6 24
% 1,5 5 4 0,7 3 «86%»@«2years»
Zone I pathology
Zone 0 pathology
? ?
J/PRAA
Short-term results PG-EVAR F/BEVAR Surgery
Renal failure 0-12.9% 7-22% 18-22%
ICU stay 2 2-4 4-5
Hospital stay 10 8-13 11-16
Paraplegia 2 0-31% 6
Stroke 0-3 0 3
Long term results PG-EVAR F/BEVAR Surgery
Branch patency 96% (5-years) 90-99% 85-100%
Endoleak I/III 5% 0-5% -
Stentgraft migration 0 0-1% -
Redos 28% 15-25% 5-8%
Considering similar 30-day mortality rates!
PG-EVAR
Author, year Pt E/U n art RA SMA CT Mort (30-d) Morb (30-d) EL I SG
Larzon, 2008 13 6 14 14 0 0 0 1 - 0
Ohrlander, 2008 6 5 11 9 2 0 1 1 - 7
Hiramoto, 2009 29 0 31 31 0 0 0 3 0 1
Bruen, 2010 21 0 35 27 8 0 1 0 1 0
Kolvenbach, 2010 5 5 17 - - - 0 1 0 17
Bruen, 2011 21 0 37 28 9 0 1 6 1 31
Coscas, 2011 16 4 26 20 6 0 2 1 2 40
Lee, 2012 28 0 57 48 6 3 2 6 2 45
Donas, 2012 30 - 38 35 3 0 0 - 0 35
Schiro, 2013 9 0 9 9 0 0 0 0 1 -
Tolenaar, 2013 13 - 22 - - - 0 2 0 -
Fukui,2013 10 0 10 10 0 0 0 0 0 -
Liu, 2013 5 0 6 6 0 0 0 0 0 1
Suominen, 2014 7 0 11 11 0 0 0 3 0 -
Ducasse, 2014 22 0 22 22 0 0 2 3 2 0
Banno, 2014 38 6 61 - - - 3 15 - -
Schwierz, 2014 32 14 104 - - - 2 5 - -
Scali, 2014 41 - 76 51 16 9 2 8 3 -
Bin Jarb, 2015 29 14 41 - - - 4 - 3 -
XiaoHui, 2015 42 - 56 - - - 0 - 8 2
Ronchey, 2015 23 23 33 29 4 - 0 8 30
Lachat, 2015* 100 27 224 161 38 24 2 15 5 90
Overall (%) 540 104 (22) 941 511 92 36 22 (4.1) 70 (17) 36 (8) 299
Ref: reference; Pt: patients; E/U: emergent/urgent repair; n art: number of
artery; RA: renal artery; SMA: superior mesenteric artery; CT: celiac trunk; Mort:
mortality; Morb: morbidity; d: days; EL I: endoleak type I; SG: stent graft. *
unpublished results
PG-EVAR Literature review
Preop Postop FUP
JRAA 3.7 mm 20.2 mm 20.1 mm
SRAA 3.8 mm 23.2 mm 23.1 mm
Craw IV 5.1 mm 21.9 mm 22.0 mm
TAAA 3.5 mm 22.6 mm 22.3 mm
Overall 3.8 mm 21.6 mm 21.5 mm
Neck length (mean in mm). A significant increase in postop neck length and FUP neck was
observed for all the pathology group when compared to the preoperative length. No
differences between postop neck length and FUP neck was observed
100 consecutive PG-EVAR @ UHZ
Mean neck length
Extra costs for fenestrated device
Costs comparison PG-EVAR vs FEVAR
Courtesy of K. Donas, Münster
Additional vessels at risk
Outcomes 29 +/-17 months
Mortality at FUP MAXTD CPG patency Reinterventions
PRAA vs TAAA 0.32 0.77 0.97 0.15
Elective vs nonelective 0.001 0.62 0.52 0.01
1-2 CPG vs 3-4 CPG 0.03 0.17 0.84 0.06
CG vs PG vs CPG 0.06 0.59 0.95 0.33
Renal vs visceral vs all 0.72 0.12 0.41 0.40
Aortic stentgraft 0.96 0.12 0.86 0.08
CPG stenosis (>70%) and/or
Very short CPGs (<5mm ) vs
No collaps or short CPG
0.30 0.76 0.06 0.02
Target vessel stenosis
(>50%) or a diameter < 4
mm
0.65 0.09 0.04 0.05
100 consecutive PG-EVAR @ UHZ
Paraplegia risk
Conclusions
PG-EVAR
sAAA
CP-EVAR (planning)
CP-EVAR result
Conclusions
• PG-EVAR shows results equivalent to other
repair techniques
517 patients, 13 centres
Conclusions
• In comparison with F/BEVAR, PG-EVAR is
simpler procedure with less manipulations and
devices and without the need of covering
unnecessary healthy aorta and eventually
aortic branches
Conclusions
Try to do this or
you are welcome in Zurich

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lachat pg@site2015

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  • 5. Author Year Patients 30d Results FUP Parallel grafts death stroke and/or paraplegia EL reintervention reintervention survival Mangialardi 2014 26 1 2 6 3 - 80%@3years Vicente 2014 1 0 0 0 0 0 100%@0.8years Synoviecz 2013 1 0 0 0 0 0 - Shahverdyan 2013 6 1 0 3 2 1 83%@0.2years Samura 2013 2 0 0 2 0 0 100%@0.5years Zhu 2013 34 0 0 2 4 4 94%@1year Chang 2013 1 0 0 0 0 0 100%@1year Zhou 2013 1 0 0 2 0 0 100%@1year Vallejo 2012 8 1 1 0 3 5 - Akchurin 2012 10 0 0 1 0 0 100%@0.5years Cires 2011 9 1 1 0 1 3 100%@0.4years Yoshida 2011 2 0 0 2 0 1 - Shu 2011 8 0 0 0 0 0 100%@1year Feng 2011 1 0 0 0 0 0 100%@1year Gehringhoff 2011 9 1 0 1 0 1 79%@1year Sugiura 2009 11 2 1 2 0 1 - Baldwin 2008 7 0 1 1 0 0 - Ohrlander 2008 4 0 0 2 1 2 Criado 2007 8 0 0 0 0 0 - Hiramoto 2006 1 0 0 0 0 0 - Larzon 2005 2 0 0 2 0 0 - Total 152 7 6 26 14 18 % 5 4 17 9 12 “94%”@”1year”
  • 6. Author Year Patients 30d Results FUP Conventional Open Repair death stroke and/or paraplegia EL reintervention reintervention survival Andersen 2012 20 2 1 - 3 0 51@5y Baraki 2007 39 5 5 - 0 3 87@1.9Y Chen 2010 28 4 6 - 1 0 88%@5y Di eusanio 2013 122 21 20 - 15 0 97%@1y Flores 2006 25 3 8 - - - - Hofferberth 2012 19 1 3 - 0 4 - Hoffmann 2012 32 1 1 - 4 0 - Ius 2013 131 20 15 - 24 0 72%@5y Jakob 2011 270 41 35 - 38 0 74%@5y Jim 2011 10 1 1 2 0 1 50%@3Y Kawaharada 2009 31 2 1 1 0 4 73%@5Y Lee 2011 21 4 3 2 0 5 - Leontyev 2013 46 4 11 - 6 0 68%@5y Lima 2012 50 4 6 1 2 0 87%@2Y Nishi 2011 61 2 6 - 0 3 - Pochettino 2009 36 5 1 - - - - Roselli 2013 17 0 2 - - - - Shen 2012 38 3 2 - - - 91%@5y Shi 2011 46 1 1 - 2 0 - Shimamura 2008 126 4 11 - 3 0 63%@5y Shimamura 2009 69 5 6 6 2 6 89%@3Y Shrestha 2012 34 3 1 - 6 2 - Sun 2013 398 31 20 - 28 0 - Uchida 2011 80 3 7 - 2 0 - Usui 2002 24 0 4 - - - 96%@1year Xiao 2013 33 6 0 0 - - - Zhao 2012 24 1 1 1 0 1 92%@5Y Total 1830 176 180 13 135 29 % 10 10 5,5 8 1,8 “79%”@”4years”
  • 7. Author Year Device Patients 30d Results FUP F/BEVAR death stroke and/or paraplegia EL reintervention reintervention survival Inoue K 1999 BEVAR-Inoue 15 0 1 4 1 4 87%@1year McWilliams 2004 FEVAR 1 0 0 0 0 0 100%@0.5Year Saito N 2005 BEVAR-Inoue 17 0 1 3 0 2 88%@2.2years Chuter T 2003 BEVAR 1 0 0 0 0 0 - Brar R 2008 BEVAR 1 0 0 0 0 0 - Kawaguchi 2008 FEVAR 288 - 16 - - - 62%@5years Sonesson 2009 FEVAR 1 0 0 0 0 - 100%@0.1Year Manning 2010 FEVAR 10 0 0 0 0 0 - Yusa 2011 FEVAR 10 0 0 1 0 0 - Lioupis 2012 BEVAR 6 0 2 2 1 0 - Spear 2013 BEVAR 1 0 0 0 0 - - Azuma 2013 FEVAR 393 6 10 12 - - - Haulon 2014 BEVAR 38 5 6 4 3 - Anderson 2015 FEVAR 2 0 0 0 0 0 100%@0.5 years Matsuyama 2015 FEVAR 37 1 2 1 0 11 65%@5years Mangialardi 2015 FEAVR- Najuta 1 0 0 0 0 0 - Tse 2015 FEVAR-insitu 6 0 1 0 0 0 - Kurimoto 2015 FEVAR 37 0 5 12 0 4 86%@2years Total 865 12 44 35 6 24 % 1,5 5 4 0,7 3 «86%»@«2years»
  • 11. Short-term results PG-EVAR F/BEVAR Surgery Renal failure 0-12.9% 7-22% 18-22% ICU stay 2 2-4 4-5 Hospital stay 10 8-13 11-16 Paraplegia 2 0-31% 6 Stroke 0-3 0 3 Long term results PG-EVAR F/BEVAR Surgery Branch patency 96% (5-years) 90-99% 85-100% Endoleak I/III 5% 0-5% - Stentgraft migration 0 0-1% - Redos 28% 15-25% 5-8% Considering similar 30-day mortality rates!
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  • 15. Author, year Pt E/U n art RA SMA CT Mort (30-d) Morb (30-d) EL I SG Larzon, 2008 13 6 14 14 0 0 0 1 - 0 Ohrlander, 2008 6 5 11 9 2 0 1 1 - 7 Hiramoto, 2009 29 0 31 31 0 0 0 3 0 1 Bruen, 2010 21 0 35 27 8 0 1 0 1 0 Kolvenbach, 2010 5 5 17 - - - 0 1 0 17 Bruen, 2011 21 0 37 28 9 0 1 6 1 31 Coscas, 2011 16 4 26 20 6 0 2 1 2 40 Lee, 2012 28 0 57 48 6 3 2 6 2 45 Donas, 2012 30 - 38 35 3 0 0 - 0 35 Schiro, 2013 9 0 9 9 0 0 0 0 1 - Tolenaar, 2013 13 - 22 - - - 0 2 0 - Fukui,2013 10 0 10 10 0 0 0 0 0 - Liu, 2013 5 0 6 6 0 0 0 0 0 1 Suominen, 2014 7 0 11 11 0 0 0 3 0 - Ducasse, 2014 22 0 22 22 0 0 2 3 2 0 Banno, 2014 38 6 61 - - - 3 15 - - Schwierz, 2014 32 14 104 - - - 2 5 - - Scali, 2014 41 - 76 51 16 9 2 8 3 - Bin Jarb, 2015 29 14 41 - - - 4 - 3 - XiaoHui, 2015 42 - 56 - - - 0 - 8 2 Ronchey, 2015 23 23 33 29 4 - 0 8 30 Lachat, 2015* 100 27 224 161 38 24 2 15 5 90 Overall (%) 540 104 (22) 941 511 92 36 22 (4.1) 70 (17) 36 (8) 299 Ref: reference; Pt: patients; E/U: emergent/urgent repair; n art: number of artery; RA: renal artery; SMA: superior mesenteric artery; CT: celiac trunk; Mort: mortality; Morb: morbidity; d: days; EL I: endoleak type I; SG: stent graft. * unpublished results PG-EVAR Literature review
  • 16. Preop Postop FUP JRAA 3.7 mm 20.2 mm 20.1 mm SRAA 3.8 mm 23.2 mm 23.1 mm Craw IV 5.1 mm 21.9 mm 22.0 mm TAAA 3.5 mm 22.6 mm 22.3 mm Overall 3.8 mm 21.6 mm 21.5 mm Neck length (mean in mm). A significant increase in postop neck length and FUP neck was observed for all the pathology group when compared to the preoperative length. No differences between postop neck length and FUP neck was observed 100 consecutive PG-EVAR @ UHZ Mean neck length
  • 17. Extra costs for fenestrated device
  • 18. Costs comparison PG-EVAR vs FEVAR Courtesy of K. Donas, Münster
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  • 21. Outcomes 29 +/-17 months Mortality at FUP MAXTD CPG patency Reinterventions PRAA vs TAAA 0.32 0.77 0.97 0.15 Elective vs nonelective 0.001 0.62 0.52 0.01 1-2 CPG vs 3-4 CPG 0.03 0.17 0.84 0.06 CG vs PG vs CPG 0.06 0.59 0.95 0.33 Renal vs visceral vs all 0.72 0.12 0.41 0.40 Aortic stentgraft 0.96 0.12 0.86 0.08 CPG stenosis (>70%) and/or Very short CPGs (<5mm ) vs No collaps or short CPG 0.30 0.76 0.06 0.02 Target vessel stenosis (>50%) or a diameter < 4 mm 0.65 0.09 0.04 0.05 100 consecutive PG-EVAR @ UHZ
  • 25. sAAA
  • 28. Conclusions • PG-EVAR shows results equivalent to other repair techniques 517 patients, 13 centres
  • 29. Conclusions • In comparison with F/BEVAR, PG-EVAR is simpler procedure with less manipulations and devices and without the need of covering unnecessary healthy aorta and eventually aortic branches
  • 31. Try to do this or you are welcome in Zurich