This document provides information about the 27th Latin American Symposium on Biotechnology, Biomedical, Biopharmaceutical, and Industrial Applications of Capillary Electrophoresis and Microchip Technology (LACE 2022) being held from December 3-6, 2022 in Panama City, Panama. The multi-day event will include a pre-symposium course, keynote presentations, poster sessions, and discussions covering various applications and advances in capillary electrophoresis, microchip technology, and related topics. Attendees will have opportunities to learn about the latest research and visit local sites of historical and natural significance in Panama.

1. 27th
LACE
2022
December 3 – 6
Organized by:
27th Latin American Symposium on Biotechnology, Biomedical, Biopharmaceutical, and Industrial Applications of Capillary Electrophoresis and Microchip Technology
Panama City,
Panama

2. Welcome
This year, the Latin American Symposium on Biotechnology, Biomedical, Biopharmaceutical, and Industrial Applications of
Capillary Electrophoresis and Microchip Technology, LACE 2022, celebrates its 27th anniversary. The LACE Organizing
Committee wishes to honor and acknowledge the significant support from numerous professors, universities, and commercial
institutions that have made it possible to carry out continuing education in nanotechnologies to new generations of teachers,
students, health professionals, and practitioners of conventional capillary electrophoresis and microchip electrophoresis
throughout Latin America and Spain.
The symposium is structured into a four-day conference beginning with the traditional pre-symposium postgraduate course,
followed by a plenary lecture, keynote lectures, and vendor seminars, as well as poster sessions, including an instrument
exposition.
Sessions will include the “omics” (genomics, proteomics, glycomics, and metabolomics), genetic analysis, bioanalysis,
biotechnology, multidimensional separation approaches, hyphenated techniques, mass spectrometry, novel instrumentation,
sample treatment, miniaturization and point-of-care devices, microfluidics, affinity interactions, microchip electrophoresis,
biopharmaceutical, food science, environmental applications, forensic science, and much more.
It is our sincere wish that your experience this year, in Panama City, Panama, be both enjoyable and professionally rewarding. In
addition, we hope that you will take advantage of the extraordinary opportunity to visit the beautiful and unique Panama Canal,
the oldest colonial relic and Spanish fort in this part of the world, as well as the first European settlement in the Pacific. Panama
has joined UNESCO and is now a member of the Regional Centre for the Safeguarding of the Intangible Cultural Heritage of Latin
America (CRESPIAL).
Welcome to Panama, the bridge between the Atlantic and the Pacific, considered to be a tropical paradise with beaches,
rainforests and exotic animals, birds, and sea life of unparalleled beauty.
Our warmest regards,
Norberto A. Guzman (Chair) Herbert H. Lindner (Co-Chair) 1

3. Organizing Committee
Chair:
Norberto A. Guzman
Princeton Biochemicals, Inc.
Princeton, New Jersey, U.S.A.
Co-Chair:
Herbert H. Lindner
University of Innsbruck
Innsbruck, Austria
Committee members
Tim Blanc
Eli Lilly and Company
Branchburg, New Jersey, U.S.A.
Antonio Cachafeiro-Vilar
Pacífica Salud – Hospital Costa del Este
Panama City, Panama
Ana Valeria C. Simionato
State University of Campinas (UNICAMP)
Campinas, Brazil
Robert Weinberger
CE Technologies, Inc.
Wayland, Massachusetts, U.S.A.
2

4. Scientific Committee
Chair: Co-Chair:
Norberto A. Guzman Herbert H. Lindner
Princeton, New Jersey, U.S.A. Innsbruck, Austria
Committee members:
Coral Barbas Fernando Benavente
Madrid, Spain Barcelona, Spain
Tim Blanc Antonio Cachafeiro-Vilar
Branchburg, New Jersey, U.S.A. Panama City, Panama
Jeff Chapman Doo Soo Chung
Southampton, U.K. Seoul, Korea
Elena Dominguez-Vega Ziad El Rassi
Leiden, The Netherlands Stillwater, Oklahoma, U.S.A.
Alberto Escarpa Alberto Fracassi da Silva
Alcalá de Henares, Madrid, Spain Campinas, Brazil
Carlos Garcia Ana María García-Campaña
Clemson, South Carolina, U.S.A. Granada, Spain
3

5. Scientific Committee
Andras Guttman Václav Kasicka
Veszprém, Hungary Prague, Czech Republic
Sergey N. Krylov Susan M. Lunte
Toronto, Canada Lawrence, Kansas, U.S.A.
Bruce McCord Marja-Liisa Riekkola
Miami, Florida, U.S.A. Helsinki, Finland
Angel Ríos Richard R. Rustandi
Ciudad Real, Spain West Point, Pennsylvania, U.S.A.
Dan Safarpour Bettina Sarg
Mount Olive, New Jersey, U.S.A. Innsbruck, Austria
Ana Valeria C. Simionato Marina F.M. Tavares
Campinas, Brazil São Paulo, Brazil
Nora M. Vizioli Robert Weinberger
Buenos Aires, Argentina Wayland, Massachusetts, U.S.A.
Adam Woolley
Provo, Utah, U.S.A.
4

6. Scientific Program
Pre-Symposium Course
The pre-symposium course will provide fundamental and comprehensive information on various aspects of
capillary electrophoresis, and microchip technology and their hyphenation to mass spectrometry, including
representative applications and omics technologies.
Main topics:
• - History of Capillary Electrophoresis (CE) Development.
• - Theoretical Aspects, and Mechanisms of Separation.
• - Optimization of Conditions for the Separation of a Wide Range of Compounds.
• - Instrumentation, High-Throughput, Automation, Portability.
• - Detection Systems and Coupling to Mass Spectrometry.
• - Multiple Background Electrolytes (Aqueous and Nonaqueous Buffers), Additives and Polymeric
Matrices.
• - Improved Methods to Enhance Sensitivity.
• - Special Topics on Applications Related to Major Industries, such as the Pharmaceutical Industry,
Biotechnology, Clinical and Forensic Laboratories, the Food and Beverage Industry, and Environmental
Monitoring.
• - Advances in Microchip Technology, Micro- and Nanotechnologies.
• - Future of CE and Microchip – Point-of-care Biomarker Analyzer.
Lecturers:
Norberto A. Guzman, Princeton Biochemicals, Inc., Princeton, New Jersey, U.S.A.
Fernando Benavente, University of Barcelona, Barcelona, Spain
Hans Dewald, Sciex, Brea, California, U.S.A.
Adam Woolley, Brigham Young University, Provo, Utah, U.S.A. 5

7. Scientific Program
Agenda of Sessions
Saturday, December 3rd Sunday, December 4th
08:00 – 09:00 Registration 08:00 – 09:00 Registration
09:00 – 13:00 Pre-Symposium course Session I
Chairperson: Adam Woolley
09:00 – 09:45
13:00 – 13:40 Lunch Break OP-A01: Smart 3D Microtechnologies
13:40 – 16:00 Poster Session and Registration for Biology and Human Health.
Dr. David H. Gracias (U.S.A.)
Inaugural Session 09:45 – 10:30
OP-A02: In Search of Chronic disease
16:00 – 16:30 Welcoming Remarks Protein Biomarkers Using a 2D Bio-
Dr. Norberto A. Guzman – U.S.A. Recognition Affinity Capture-Enrichment
Dr. Antonio Cachafeiro – Panama CE Approach.
Dr. Norberto A. Guzman (U.S.A.)
16:30 – 17:15 Tribute to Dr. Paul Farmer
Norberto Guzman – U.S.A. 10:30 – 10:50
Coffee Break
17:30 – 20:00 Reception - Cocktail
6

8. Sunday, December 4th Sunday, December 4th
Session II Session III
Chairperson: Dr. Herbert H. Lindner Chairperson: Dr. Fernando Benavente
10:50 – 11:30 12:50 – 13:40
OP-A03: Using Microprobe In-Emitter Elution OP-LS01 – Lunch Seminar
Coupled with High-Resolution MS for the Clinical Urine Metabolomics Using a Novel
Characterization and Identification of Capillary – Mass Spectrometry System
𝛽2-Transferrin. Dr. James Xia (U.S.A.)
Dr. Ruben Luo (U.S.A.)
11:30 – 12:10 13:40 – 14:40 – Poster Session
OP-A04: Electrophoresis-Enhanced Lateral
Flow Immunoassay for Highly Sensitive Session IV
Analysis of Viral Antigen. Chairperson: Dr. Andras Guttman
Dr. Sergey N. Krylov (Canada)
11:10 – 12:50 14:40 – 15:20
OP-A05: Bioengineering at the Service of the OP-A06: Liquid Extraction Surface Analysis
Panamanian Public Health System: The Case with Capillary Electrophoresis
Of Nanomodified Biomaterials for Tissue Dr. Doo Soo Chung
Regeneration.
Dr. Rolando Gittens (Panama)
7

9. 8

10. Monday, December 5th Monday, December 5th
09:40 – 10:20 12:00 – 12:40
OP-A13: Capillary Electrophoresis of OP-A16: Simul 6 – A Fast Dynamic Simulator
Cannabinoids in Flowers and Edibles. of Electromigration.
A Feasibility Study. Dr. Bohuslav Gaš (Czech Republic)
Dr. Robert Weinberger (U.S.A.)
12:40 – 13:40 – Lunch Seminar
10:20 – 11:00 OP-LS02: Doubling Down on Sample
OP-A14: Isolation, Fractionation, and Preparation – Live.
Characterization of Plasma-Derived Dr. Jeff Chapman (United Kingdom)
Nanosized Extravesicular Vesicle
Subpopulations. 13:40 – 14:40 – Poster Session
Dr. Marja-Liisa Riekkola (Finland)
Session VIII
11:00 – 11:20 – Coffee Break Chairperson: Dr. Richard Rustandi
Session VII 14:40 – 15:20
OP-A17: Electrochemical Detection for Low -
Chairperson: Dr. Nora M. Vizioli Cost Fabrication of Microfluidic Devices.
Towards the Measurement of Biochemical
11:20 – 12:00 Reactions in Cell Cultures.
OP-A15: High-Sensitivity Analysis of Dr. Alberto Escarpa (Spain)
Protein Biomarkers at the Intact and
Peptide Map Level by On-Line Aptamer
Affinity Solid-Phase Extraction CE-MS.
Dr. Fernando Benavente (Spain)
9

11. Monday, December 5th Monday, December 5th
15:20 – 16:00 17:40 – 18:10
OP-A18: Unveiling the Metabolic Effects of OP-A21: Cutting-Edge Capillary – Mass
Oxidative Stress in Heart Cells by Liquid Spectrometry in Biotherapeutics
Chromatography – Mass Spectrometry. Characterization, Proteomics, and
Dr. Ana Valéria Simionato (Brazil) Clinical Metabolomics.
Dr. James Xia (U.S.A.)
16:00 – 16:40
OP-A19: Contribution of Capillary Electrophoresis 19:30 – 22:00 – Gala Dinner
In Analytical Science: Nanomaterial – From Tools
to Targets.
Dr. Ángel Ríos (Spain) Tuesday, December 6th
16:40 – 17:00 – Coffee Break Session X
Session IX Chairperson: Dr. Ana Valéria Simionato
Chairperson: Dr. Robert Weinberger 09:00 – 09:45
OP-A-22: A Carboxyl Monolith Precursor
17:00 – 17:40 for Post-Polymerization Functionalization with
OP-A20: Application of High – Resolution Mass Polar, Non-Polar, and Chiral Ligands for
Spectrometry for the Determination of Chemical Capillary Electrochromatographic Separation.
Cross Contaminants in a Variety of Matrices. Dr. Ziad El Rassi (U.S.A.)
Dr. Dan Safarpour (U.S.A.)
10

12. Tuesday, December 6th Tuesday, December 6th
09:45 – 10:35 Post-LACE Activities
OP-A23: N-Terminal Pro-B-Type Natriuretic Arranged with a Travel Agency
Peptide, a Widely Used Biomarker for Visit to the Canal of Panama
Severe Heart Failure – The Challenge of
Unraveling Its Molecular Complexity. Wednesday, December 7th
Dr. Herbert H. Lindner (Austria)
Arranged with a Travel Agency
10:35 – 11:50 Beach Day at Taboga Island
OP-A24: Remembering Dr. Ernst Kenndler:
A Pioneer in Capillary Electrophoresis and
Its Basic Principles.
Dr. Norberto A. Guzman (U.S.A.)
11:50 – 12:20
Coffee Break
Closing Remarks and Awards
Pictures Session
11

13. Poster Sessions from Saturday, December 3rd – to – Tuesday, December 6th
P-A25: Characterization of Lentiviral Vector Quality P-A33: Rapid Detection of Staphyloccus aureus Using Paper-Derived
Attributes Using Capillary Electrophoresis Technology. Electrochemical Biosensors.
Dr. Yang Lu (U.S.A.) Dr. Carlos D. Garcia (U.S.A.)
P-A26: Identification of Glycosylated (N-Terminal) Pro- P-A34: Detection of Organics in High Salinity Samples Relevant to
B-Type Natriuretic Peptide Forms in Blood Plasma of Future Missions to Ocean Worlds by Capillary Electrophoresis Coupled
Patients with Severe Heart Failure. to Mass Spectrometry.
Dr. Herbert Lindner (Austria) Dr. M. Fernanda Mora (U.S.A.)
P-A27: Accurate Identification of Hemoglobin Variants P-A35: Quantification of Human Chorionic Gonadotrophin Isoforms
by Top-Down Protein Analysis Using Capillary by Capillary Electrophoresis.
Electrophoresis-High Resolution Mass Spectrometry. Dr. Nora M. Vizioli (Argentina)
Dr. Ruben Y. Luo (U.S.A.)
P-A36: Is Your Protein Endogenously Processed or Just Badly Prepared? –
P-A28: Identification and Characterization of Protein A Method that Allows Distinction Between In Vivo and In Vitro Proteoforms.
Biomarkers in Biological Fluids and Tissue Biopsies Dr. Herbert H. Lindner (Austria)
by Immunoaffinity Capillary Electrophoresis.
Dr. Norberto A. Guzman (U.S.A.) P-A37: Bipolar Electro–Based Fluorescence Detection with Microchip
Electrophoresis: Proof of Concept with Nitrated Tyrosine Compounds.
P-A29: A Microchip Electrophoresis Device for Automatic Dr. Indika K. Warnakula (Austria)
High–Throughput Determination of Intracellular Nitric Oxide
Production in Microglia at the Single-Cell Level. P-A38: Determination of a Lectin Protein Allergen in Food by On-Line
Dr. Jay Sibbitts (U.S.A.) Aptamer Affinity Solid-Phase Extraction CE–MS.
Dr. Fernando Benavente (Spain)
P-A30: Microseparation Techniques Coupled to Mass Spectro-
metry for Glycoform Separation and Unequivocal Identification P-A39: Evaluation of Fragile X Mental Retardation Protein Levels in Neonatal
of Peptides. Intense Care Unit Infants.
Dr. Fernando Benavente (Spain) Ms. Elaine Marchi (U.S.A.)
P-A31: The Use of Polymeric Nanoparticles to Improve Protein
Separation in a Complex Matrix by Capillary Electrophoresis.
Dr. Nora M. Vizioli (Argentina)
P-A32: Capillary Electrophoresis and ICP-MS/MS Coupling as a
Valuable Tool in the Investigation of Superparamagnetic Iron
Oxide Nanoparticles and Human Serum Interactions.
M.Sc.Eng. Anna M. Wróblewska (Poland)
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14. 27th
LACE
2022
December 3 – 6
Panama City,
Panama
LACE
Latin American
Capillary Electrophoresis
Symposium Series