This presentation was created for a health policy class as part of a nursing practice doctoral program. It reviews the pro-and cons of creating a health policy to allow medical marijuana.
3. Why Consider Considering?
Need for research, not anecdotes
KY leads the nation in non-medical use of
controlled pain relievers and tranquilizers
We are loosing millions of dollars in potential
revenue
We are spending millions of dollars in
prohibition
4. If all the other states jumped
off a bridge . . .
Effective: CA, AK, OR, WA, ME, CO, NV, HI,
VT, MT, RI, NM, MI
Workable: MD
Research: AL, GA, IL, MA, MN, NJ, NY, SC,
TX
Symbolic: AZ, CT, DC, IA, LA, NH, TN, VA,
WI
Expired/Repealed: AR, FL, NC, OH, WV
(MPP, 2008)
5. Current KY Law
218A.1421 - trafficking marijuana.
< 8 oz: Class A misdemeanor 1st, Class D
felony 2ed & subsequent offence
>8oz <5lbs: Class D felony 1st, Class C felony
2nd & subsequent
5+lbs: Class C felony 1st, Class B 2nd &
subsequent
Possession >8z + intent to sell/transfer
902 KAR 55:020 - MJ and THC schedule I;
Marinol schedule III
6. Getting Around
Federal Law
Illegal to possess, grow, or distribute since
1937
Can be enforced anywhere in the US
Cannot force state authorities to enforce
federal law
Cannot force state to have identical federal
law
99% of MJ arrests are by state & local, not
federal, authorities
States determine drug scheduling class
7. Marijuana Basics
Pharmacokinetics
Pharmacodynamics
Short term effects
Delivery methods
Smoke
Vapor
Ingestion
8. Current “Recommended”
Medical Uses
Chemotherapy related N/V
AIDS/HIV Wasting Disorder
Terminal Illness/ChronicPain
Glaucoma
9. Other “Recommendations”
(“but it really works, doc”)
Alzheimer's Agitation/Prevention
Asthma & Breathing Disorders
GI Disorders
Epilepsy and Seizure Disorders
Hepatitis C
Migraines
Multiple Sclerosis
Psychological Disorders (including PMS)
Tourette's syndrome
11. Marinol
Synthetic delta-9-Tetrahydrocannabinol (THC)
approved by FDA for n/v & appetite stimulant
Low diversion & abuse led DEA to move from
schedule II to schedule III in 1998
Patch & inhaler under development
Safe, regulated dose without chemicals or tar
Longer onset & effect, increased psychoactive
effects, only one active ingredient
Metabolized by CP450 3A4/2C9
(USDEA, 2010 )
12. Coming Soon . . . Sativex
Approved in Europe & Canada
In Phase III in US clinical trial
Indicated for neuropathic pain relief in MS
and cancer
Natural extract THC & CBD
Spray delivery
Less intoxication
Statistically significant improvement
compared to placebo/existing medications
13. GO vs NO
Provides alleviating Efficacy of existing
therapy for multiple & emerging
disorders
pharmaceuticals
Lower addiction potential
than opioid analgesics No reliable field
Regulations ensure sobriety test
potency & purity “Recommended”
Generates state revenue use is a farce
& decreases spending Risk>Benefit
Benefit>Risk
Lack of reliable clinical research
14. Recommended Model
Legislation for KY
MD in certain specialties may certify MJ for use in
specific, pre-determined conditions for maximum 1
year
Register with health department for ID tracking card
Possess up to 6oz and 12 plants
State-regulated, non-profit dispensaries
Prohibit public use and driving
Medical necessity defense not permissible
Employers and insurers may restrict
16. Sources Consulted
AMA Policy: Medical Marijuana (2009). Retrieved from
http://medicalmarijuana.procon.org/sourcefiles/AMA09policy.pdf
Gettman, John (2009). Marijuana arrests in the United States (2007):
Arrests, usage, and related data [Electronic version]. The bulletin of
cannabis reform, 1-24. Retrieved from
http://www.drugscience.org/Archive/bcr7/Gettman_Marijuana_Arrests_in
_the_United_States.pdf
Marijuana Policy Project (2008). State-by-state medical marijuana
laws:How to remove the threat of arrest [PDF document]. Retrieved from
http://www.mpp.org/assets/pdfs/download-
materials/SBSR_NOV2008_1.pdf
Net Resources International (n.d.). Sativex: Investigational cannabis-
based treatment for pain and multiple sclerosis. Retrieved from
http://www.drugdevelopment-technology.com/projects/sativex/
17. Sources Consulted
Net Resources International (n.d.). Sativex: Investigational cannabis-
based treatment for pain and multiple sclerosis. Retrieved from
http://www.drugdevelopment-technology.com/projects/sativex/
Office of National Drug Control Policy Drug Policy Information
Clearinghouse (2008). State of Kentucky: Profile of drug indicators
[PDF document]. Retreived from
http://www.ondcp.gov/statelocal/ky/ky.pdf
U.S. Department of Health and Human Services, (2005). Prescription
drugs abuse and addiction. National Institute on Drug Abuse
Research Report Series [Electronic version]. Retrieved from
http://www.drugabuse.gov/PDF/RRPrescription.pdf
U.S. Drug Enforcement Administration (n.d.). “Medical” marijuana -
The facts. Retrieved from
http://www.justice.gov/dea/ongoing/marinol.html
Editor's Notes
Case studies, small cohort studies, anedotal; AMA called for more research on smoked product "and related cannabinoids in patients who have serious conditions for which preclinical, anecdotal, or controlled evidence suggests possible efficacy" ; because schedule I (no accepted clinical use) hard to do research and not FDA approved - "Despite more than 30 years of clinical research, only a small number of randomized, controlled trials have been conducted on smoked cannabis. ” - not endoresement, just a call for rsearch - http://medicalmarijuana.procon.org/sourcefiles/AMA09policy.pdf 4th for stimulants; More people abuse rx drugs than cocaine, hallucinogens, inhalents, heroin combined;; Hydrocodone & Xanax - under-prescribing, over-prescribing, short term therapy turns into long term addiction, unsatisfactory pain control, non-controlled substances higher addiction potential and “better” than non-controlled 2006 KY ranked #3 in MJ cultivation with a value of $4.5 - most is diverted to surrounding states - not including hemp production or selling to other states; expense related to plant eradication and law enforcement; mexican smuggling rings; highest % drug related arrests; nearly 90% possessions only 2007 KY #3 in nation of MJ arrests; 65% all drug arrests; 93% possetion only; 125 million in judical/legal, correction and policing 2006; fedral destruction and investigation http://medicalmarijuana.procon.org/sourcefiles/AMA09policy.pdf Gettman, John (2007). Marijuana arrests in the United States (2007): Arrests, usage, and related data. The bullitin of cannibus reform. http://www.drugscience.org/Archive/bcr7/Gettman_Marijuana_Arrests_in_the_United_States.pdf National Instituteon Drug Abuse (Prescription drugs abuse and addiction Office of National Drug Control Policy: Drug Policy information clearinghouse: State of Kentucky profile of drug indicators; Feb 2008
Effective (13): no criminal penalties, recommend by MD - some states specify conditions, CA does not; limits amount allowed to possess/cultivate Workable (1) - taken to court with max fine 100 if can show medical necessity, relience on dealers Research (9) - cumbursome and difficult to enroll Symbolic (9) - prescribe in verbage which caanot be done due to schedule I classification; recognize value but no pt access; require federal supply 14 states none
Alaske, Hawaii, Montana, Tennessee and DC took out of schedule one Obama clled off the feds as long as individual use was in strict compliance with state law - still raided 4 CA dispensaries suspected of drug dealing
Pharmacokinetics: Peak plasma 10 minutes after smoking, 2-3 hour psycoactive componant, Half-life 1+ days, Lipid soluble and detectable 30+ days, Elimination1/3 renal; 2/3 fecal, Metabolized by cytochrome P450 system Pharmacodynamics: 460 compounds; 60 cannabinoids, CB1 & CB2 receptors in brain & immune system, Neuronal excitability & neurotransmitter release Short Term Effects: Dry mouth, Red eyes and decreased IOC, Change in sink sensation, Increased heart rate, Muscle relaxation, Memory, concentration, and coordination impairment Smoking (full/partial plant) Effects < 1 minute Respiratory illness, CA, effective 1-2 hours Vaporization Greater effect than smoking, less respiratory/ cancer risk, less product Expensive, not as effective, 1-2 hours duration Ingesting (oil, plant, tincture, butter) Safer, less psychogenic effect, easy to modulate, longer lasting effects 30-90 minutes for effect, weaker, “guessing” therapeutic dose, GI/Neuro SE
Chemo - marinol vs smoked argument, but rx meds still better AIDS - helps gain weight but decreases immunity and smoked form increases bronchitis/pneumonia Pain - r/t arthritis evdence is anecdotal both sides; increase pain sensation vs less s/e, equal pain control and addiction; inebriation is not pain control; What the hell - they are going to die anyway! Glaucoma decreases IOP in frequnet doses - direct forms in development; 1978-1992 Compassionate Investigational New Drug Program glucoma fed provided MJ, AIDS It was used way back when . . . When they were still using sulfa and leaches
Asthma - short-term bronchodilation (to get the toxins in better) vs pulmonary symptoms & dx and structural abnormalities GI - anecdotal with antiinflammatory arguments going both ways; largely anecdotal Epilepsy - induce and prevent case studies Hep - increase fibrosis, helps SE of meds Migraines - anecdotal M/s - montel williams & makes more balance and posture problems Psych - antidepressednt but illusion b/a motivation, productivity, social/sociatial production not enhanced - helps symptoms, not root cause; increase risk of psychosis Touretts - induces calming, anxiety is a contributing factor to increase in symptoms
Chemo/AIDS 400 chemicals 4xs tar “ but I don’t want to swallow a pill” - well, smoke can make you nauseated too!
Side effects similar to MJ - “high” most frequent with other smoked Chronic high dose motivation, cognition, judgment, and perception Abrupt d/c - 12-48 hours w/d symptoms irrate, hot flash, sweat, insomnia, restless http://www.rxlist.com/marinol-drug.htm Marinol:MJ what Morphine:Opium
Like tinctures in 1930s
Problem with out health care (disease care) model: Don ’t fix whats broken, we just keep replacing the same bad parts Moral (degrade society, reduce MDs to drug pushers, against God) and emotional arguments (the people in pain, alcohol is worse and its legal) Farce = case for total legalization
Oncology, pain management, ophthalmology, neurology Links with Kasper Caregiver registration if unable to cultivate by self Non-profit, subject to inspection, minimum security/record keeping No possession or intoxication; not cover http://www.mpp.org/assets/pdfs/library/Model-Bill-One-Pager-1.pdf